American Journal of Nursing Science

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Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin

Received: Dec. 04, 2017    Accepted: Dec. 06, 2017    Published: Dec. 25, 2017
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Abstract

Introduction: Chronic hepatitis C is a serious public health problem worldwide. Approximately eighty percent of the patients with acute infection will fall back to chronicity with long term complications such as cirrhosis, liver failure, hepatocellular cancer and death. The HCV infection per se has been found to be related with a variety of neuropsychiatric symptoms. Treatment of hepatitis C with interferon plus ribavirin is related with many side effects and affects the quality of patients’ life. Purpose: The purpose of this study is to assess the quality of life in patients with chronic hepatitis C undergoing treatment with interferon and Ribavirin. Data and Methodology: The research sample was 173 patients with hepatitis C who were treated in the Outpatient Liver Unit, 2nd Department of Internal Medicine, Medical School of Athens, Hippokratio General Hospital". The data were hand- collected after the Short Form 36 scale completion by the patients. For the data analysis the statistical package SPSS 13 was used and more specifically statistical t-test and anova analysis. Results: Out of all the patients participated in the study the 28.9% were women and 71.1% were men with an average age of 54.4 years with a standard deviation of 8.14 years. The 87.3% had concomitant diseases; 88.4% diabetes, 56.6% hypertension and 59.5% high cholesterol. 38.15% of the sample had re-admitted to the hospital, 18.40% had previous heart attack and 63.16% were former smokers. The statistical analysis indicated those who had a higher education degree peported higher quality of life sores in the dimensions of mental health (p=0.001), physical function (p=0.01) and vitality (p=0.000). Similar, married patients reported higher quality of life scoers in several dimension as well as patients without readmissions, patients without comorbidities and non-smokers. Conclusions: treatment with interferon and Ribavirin affects the quality of life of patients with chronic hepatitis C. Factors such as age, lifestyle, educational level, the reintroduction in the hospital and marital status can affect the life and mental health of the patient. The factors that adversely affect the quality of life must be identified and treated promptly by health professionals

DOI 10.11648/j.ajns.s.2018070301.22
Published in American Journal of Nursing Science ( Volume 7, Issue 3-1, June 2018 )

This article belongs to the Special Issue Nursing Education and Research

Page(s) 77-85
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Quality of Life, Hepatitis C, Treatment, Interferon, Ribavirin

References
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Cite This Article
  • APA Style

    Andriana Theodorakopoulou, Maria Kapella, Vasiliki Kontou, Sofia Giovaso, Theodoros Katsaras, et al. (2017). Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin. American Journal of Nursing Science, 7(3-1), 77-85. https://doi.org/10.11648/j.ajns.s.2018070301.22

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    ACS Style

    Andriana Theodorakopoulou; Maria Kapella; Vasiliki Kontou; Sofia Giovaso; Theodoros Katsaras, et al. Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin. Am. J. Nurs. Sci. 2017, 7(3-1), 77-85. doi: 10.11648/j.ajns.s.2018070301.22

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    AMA Style

    Andriana Theodorakopoulou, Maria Kapella, Vasiliki Kontou, Sofia Giovaso, Theodoros Katsaras, et al. Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin. Am J Nurs Sci. 2017;7(3-1):77-85. doi: 10.11648/j.ajns.s.2018070301.22

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  • @article{10.11648/j.ajns.s.2018070301.22,
      author = {Andriana Theodorakopoulou and Maria Kapella and Vasiliki Kontou and Sofia Giovaso and Theodoros Katsaras and Spilios Manolakopoulos and Dimitris Pectasidis and John Koskinas},
      title = {Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin},
      journal = {American Journal of Nursing Science},
      volume = {7},
      number = {3-1},
      pages = {77-85},
      doi = {10.11648/j.ajns.s.2018070301.22},
      url = {https://doi.org/10.11648/j.ajns.s.2018070301.22},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajns.s.2018070301.22},
      abstract = {Introduction: Chronic hepatitis C is a serious public health problem worldwide. Approximately eighty percent of the patients with acute infection will fall back to chronicity with long term complications such as cirrhosis, liver failure, hepatocellular cancer and death. The HCV infection per se has been found to be related with a variety of neuropsychiatric symptoms. Treatment of hepatitis C with interferon plus ribavirin is related with many side effects and affects the quality of patients’ life. Purpose: The purpose of this study is to assess the quality of life in patients with chronic hepatitis C undergoing treatment with interferon and Ribavirin. Data and Methodology: The research sample was 173 patients with hepatitis C who were treated in the Outpatient Liver Unit, 2nd Department of Internal Medicine, Medical School of Athens, Hippokratio General Hospital". The data were hand- collected after the Short Form 36 scale completion by the patients. For the data analysis the statistical package SPSS 13 was used and more specifically statistical t-test and anova analysis. Results: Out of all the patients participated in the study the 28.9% were women and 71.1% were men with an average age of 54.4 years with a standard deviation of 8.14 years. The 87.3% had concomitant diseases; 88.4% diabetes, 56.6% hypertension and 59.5% high cholesterol. 38.15% of the sample had re-admitted to the hospital, 18.40% had previous heart attack and 63.16% were former smokers. The statistical analysis indicated those who had a higher education degree peported higher quality of life sores in the dimensions of mental health (p=0.001), physical function (p=0.01) and vitality (p=0.000). Similar, married patients reported higher quality of life scoers in several dimension as well as patients without readmissions, patients without comorbidities and non-smokers. Conclusions: treatment with interferon and Ribavirin affects the quality of life of patients with chronic hepatitis C. Factors such as age, lifestyle, educational level, the reintroduction in the hospital and marital status can affect the life and mental health of the patient. The factors that adversely affect the quality of life must be identified and treated promptly by health professionals},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin
    AU  - Andriana Theodorakopoulou
    AU  - Maria Kapella
    AU  - Vasiliki Kontou
    AU  - Sofia Giovaso
    AU  - Theodoros Katsaras
    AU  - Spilios Manolakopoulos
    AU  - Dimitris Pectasidis
    AU  - John Koskinas
    Y1  - 2017/12/25
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajns.s.2018070301.22
    DO  - 10.11648/j.ajns.s.2018070301.22
    T2  - American Journal of Nursing Science
    JF  - American Journal of Nursing Science
    JO  - American Journal of Nursing Science
    SP  - 77
    EP  - 85
    PB  - Science Publishing Group
    SN  - 2328-5753
    UR  - https://doi.org/10.11648/j.ajns.s.2018070301.22
    AB  - Introduction: Chronic hepatitis C is a serious public health problem worldwide. Approximately eighty percent of the patients with acute infection will fall back to chronicity with long term complications such as cirrhosis, liver failure, hepatocellular cancer and death. The HCV infection per se has been found to be related with a variety of neuropsychiatric symptoms. Treatment of hepatitis C with interferon plus ribavirin is related with many side effects and affects the quality of patients’ life. Purpose: The purpose of this study is to assess the quality of life in patients with chronic hepatitis C undergoing treatment with interferon and Ribavirin. Data and Methodology: The research sample was 173 patients with hepatitis C who were treated in the Outpatient Liver Unit, 2nd Department of Internal Medicine, Medical School of Athens, Hippokratio General Hospital". The data were hand- collected after the Short Form 36 scale completion by the patients. For the data analysis the statistical package SPSS 13 was used and more specifically statistical t-test and anova analysis. Results: Out of all the patients participated in the study the 28.9% were women and 71.1% were men with an average age of 54.4 years with a standard deviation of 8.14 years. The 87.3% had concomitant diseases; 88.4% diabetes, 56.6% hypertension and 59.5% high cholesterol. 38.15% of the sample had re-admitted to the hospital, 18.40% had previous heart attack and 63.16% were former smokers. The statistical analysis indicated those who had a higher education degree peported higher quality of life sores in the dimensions of mental health (p=0.001), physical function (p=0.01) and vitality (p=0.000). Similar, married patients reported higher quality of life scoers in several dimension as well as patients without readmissions, patients without comorbidities and non-smokers. Conclusions: treatment with interferon and Ribavirin affects the quality of life of patients with chronic hepatitis C. Factors such as age, lifestyle, educational level, the reintroduction in the hospital and marital status can affect the life and mental health of the patient. The factors that adversely affect the quality of life must be identified and treated promptly by health professionals
    VL  - 7
    IS  - 3-1
    ER  - 

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Author Information
  • Hemodynamic Laboratory, Hippokration General Hospital, Athens, Greece

  • Director of Nursing, Hippokration General Hospital, Athens, Greece

  • Department of Nursing Specialities, Hippokration General Hospital, Athens, Greece

  • Hemodynamic Laboratory, Onassis Cardiac Surgery Center, Athens, Greece

  • Psychiatric Department, Sotiria Hospital, Athens, Greece

  • 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece

  • 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece

  • 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece

  • Section