Science Journal of Public Health

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Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status

Received: Sep. 23, 2020    Accepted:     Published: Nov. 27, 2020
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Abstract

Objective: To investigate the correlation between thyroid function stratification and autoantibody titers in patients with Graves’ disease (GD) under different iodine nutrition conditions. Methods: The levels of serum thyroid hormones, autoantibodies and urinary iodine in 100 patients with different thyroid function GD [GD-A, GD-B] and 60 healthy subjects are detected by electrochemical immunoluminescence and iodine-catalyzed arsenic-cerium method. Results: The proportion of GD patients with the sum of iodine overdosage and iodine overdosage group is consistent with iodine adequate group, which is significantly higher than iodine deficiency group, and the (Median Urine Iodine, MUI) of GD-A group is significantly higher than GD-B group. Urinary iodine levels in GD group and GD-A group are positively correlated with serum FT3 and FT4 (P<0.05), and negatively correlated with (thyroid stimulating hormone, TSH) (P<0.05). The levels of serum (thyroid peroxidase antibody, TPOAb) and (thyroid globulin antibody, TGAb) in each GD group are significantly higher than those in the control group. Serum TSH levels in the high TPOAb group and high TgAb group are lower than those in the low TPOAb group, low TgAb group and control group, respectively. The levels of FT3 and FT4 are higher than those of the low TPOAb group and the low TgAb group, however, there is no significant difference between the FT3 of low TgAb and T3 and T4 levels that belong to the control group, high TPOAb group, high TgAb group, low TPOAb group, and low TgAb group. In conclusion: GD patients with different thyroid functions have corresponding changes in their thyroid hormone and autoantibody levels under different iodine nutrition conditions, which indicates that iodine nutrition status involve in and play an important role in the development of GD with different thyroid functions and different antibody levels.

DOI 10.11648/j.sjph.20200806.13
Published in Science Journal of Public Health ( Volume 8, Issue 6, November 2020 )
Page(s) 168-176
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Thyroid Hormone, Median Urine Iodine, Thyroid Autoantibodies, Graves’ Disease, Hyperthyroidism

References
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  • APA Style

    Jing Feng, Cuicui Wang, Zhaoxin Mu, Xinsheng Li, Zhenjiang Hou. (2020). Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status. Science Journal of Public Health, 8(6), 168-176. https://doi.org/10.11648/j.sjph.20200806.13

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    ACS Style

    Jing Feng; Cuicui Wang; Zhaoxin Mu; Xinsheng Li; Zhenjiang Hou. Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status. Sci. J. Public Health 2020, 8(6), 168-176. doi: 10.11648/j.sjph.20200806.13

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    AMA Style

    Jing Feng, Cuicui Wang, Zhaoxin Mu, Xinsheng Li, Zhenjiang Hou. Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status. Sci J Public Health. 2020;8(6):168-176. doi: 10.11648/j.sjph.20200806.13

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  • @article{10.11648/j.sjph.20200806.13,
      author = {Jing Feng and Cuicui Wang and Zhaoxin Mu and Xinsheng Li and Zhenjiang Hou},
      title = {Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status},
      journal = {Science Journal of Public Health},
      volume = {8},
      number = {6},
      pages = {168-176},
      doi = {10.11648/j.sjph.20200806.13},
      url = {https://doi.org/10.11648/j.sjph.20200806.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjph.20200806.13},
      abstract = {Objective: To investigate the correlation between thyroid function stratification and autoantibody titers in patients with Graves’ disease (GD) under different iodine nutrition conditions. Methods: The levels of serum thyroid hormones, autoantibodies and urinary iodine in 100 patients with different thyroid function GD [GD-A, GD-B] and 60 healthy subjects are detected by electrochemical immunoluminescence and iodine-catalyzed arsenic-cerium method. Results: The proportion of GD patients with the sum of iodine overdosage and iodine overdosage group is consistent with iodine adequate group, which is significantly higher than iodine deficiency group, and the (Median Urine Iodine, MUI) of GD-A group is significantly higher than GD-B group. Urinary iodine levels in GD group and GD-A group are positively correlated with serum FT3 and FT4 (P<0.05), and negatively correlated with (thyroid stimulating hormone, TSH) (P<0.05). The levels of serum (thyroid peroxidase antibody, TPOAb) and (thyroid globulin antibody, TGAb) in each GD group are significantly higher than those in the control group. Serum TSH levels in the high TPOAb group and high TgAb group are lower than those in the low TPOAb group, low TgAb group and control group, respectively. The levels of FT3 and FT4 are higher than those of the low TPOAb group and the low TgAb group, however, there is no significant difference between the FT3 of low TgAb and T3 and T4 levels that belong to the control group, high TPOAb group, high TgAb group, low TPOAb group, and low TgAb group. In conclusion: GD patients with different thyroid functions have corresponding changes in their thyroid hormone and autoantibody levels under different iodine nutrition conditions, which indicates that iodine nutrition status involve in and play an important role in the development of GD with different thyroid functions and different antibody levels.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Correlation Analysis of Thyroid Function and Autoantibodies in Graves’ Disease Patients with Different Iodine Nutritional Status
    AU  - Jing Feng
    AU  - Cuicui Wang
    AU  - Zhaoxin Mu
    AU  - Xinsheng Li
    AU  - Zhenjiang Hou
    Y1  - 2020/11/27
    PY  - 2020
    N1  - https://doi.org/10.11648/j.sjph.20200806.13
    DO  - 10.11648/j.sjph.20200806.13
    T2  - Science Journal of Public Health
    JF  - Science Journal of Public Health
    JO  - Science Journal of Public Health
    SP  - 168
    EP  - 176
    PB  - Science Publishing Group
    SN  - 2328-7950
    UR  - https://doi.org/10.11648/j.sjph.20200806.13
    AB  - Objective: To investigate the correlation between thyroid function stratification and autoantibody titers in patients with Graves’ disease (GD) under different iodine nutrition conditions. Methods: The levels of serum thyroid hormones, autoantibodies and urinary iodine in 100 patients with different thyroid function GD [GD-A, GD-B] and 60 healthy subjects are detected by electrochemical immunoluminescence and iodine-catalyzed arsenic-cerium method. Results: The proportion of GD patients with the sum of iodine overdosage and iodine overdosage group is consistent with iodine adequate group, which is significantly higher than iodine deficiency group, and the (Median Urine Iodine, MUI) of GD-A group is significantly higher than GD-B group. Urinary iodine levels in GD group and GD-A group are positively correlated with serum FT3 and FT4 (P<0.05), and negatively correlated with (thyroid stimulating hormone, TSH) (P<0.05). The levels of serum (thyroid peroxidase antibody, TPOAb) and (thyroid globulin antibody, TGAb) in each GD group are significantly higher than those in the control group. Serum TSH levels in the high TPOAb group and high TgAb group are lower than those in the low TPOAb group, low TgAb group and control group, respectively. The levels of FT3 and FT4 are higher than those of the low TPOAb group and the low TgAb group, however, there is no significant difference between the FT3 of low TgAb and T3 and T4 levels that belong to the control group, high TPOAb group, high TgAb group, low TPOAb group, and low TgAb group. In conclusion: GD patients with different thyroid functions have corresponding changes in their thyroid hormone and autoantibody levels under different iodine nutrition conditions, which indicates that iodine nutrition status involve in and play an important role in the development of GD with different thyroid functions and different antibody levels.
    VL  - 8
    IS  - 6
    ER  - 

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Author Information
  • Cangzhou Central Hospital, Cangzhou, China

  • Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

  • Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

  • Cangzhou Central Hospital, Cangzhou, China

  • Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

  • Section