Journal of Health and Environmental Research

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Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients

Received: Jan. 22, 2019    Accepted: Mar. 06, 2019    Published: Mar. 21, 2019
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Abstract

Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.

DOI 10.11648/j.jher.20190501.14
Published in Journal of Health and Environmental Research ( Volume 5, Issue 1, March 2019 )
Page(s) 24-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sofosbuvir, Ribavirin, Pegylated Interferon, Hepatitis C, Hematological Toxicity

References
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  • APA Style

    Kamilia Guedri, Aziez Chettoum, Nawel Attoui. (2019). Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. Journal of Health and Environmental Research, 5(1), 24-31. https://doi.org/10.11648/j.jher.20190501.14

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    ACS Style

    Kamilia Guedri; Aziez Chettoum; Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J. Health Environ. Res. 2019, 5(1), 24-31. doi: 10.11648/j.jher.20190501.14

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    AMA Style

    Kamilia Guedri, Aziez Chettoum, Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J Health Environ Res. 2019;5(1):24-31. doi: 10.11648/j.jher.20190501.14

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  • @article{10.11648/j.jher.20190501.14,
      author = {Kamilia Guedri and Aziez Chettoum and Nawel Attoui},
      title = {Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients},
      journal = {Journal of Health and Environmental Research},
      volume = {5},
      number = {1},
      pages = {24-31},
      doi = {10.11648/j.jher.20190501.14},
      url = {https://doi.org/10.11648/j.jher.20190501.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jher.20190501.14},
      abstract = {Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients
    AU  - Kamilia Guedri
    AU  - Aziez Chettoum
    AU  - Nawel Attoui
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    DO  - 10.11648/j.jher.20190501.14
    T2  - Journal of Health and Environmental Research
    JF  - Journal of Health and Environmental Research
    JO  - Journal of Health and Environmental Research
    SP  - 24
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2472-3592
    UR  - https://doi.org/10.11648/j.jher.20190501.14
    AB  - Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Biology, University Larbi Tebessi, Tebessa, Algeria

  • Department of Biology Animal, University Mentouri, Constantine, Algeria

  • Department of Biology, University Tahri Mohamed, Bechar, Algeria

  • Section