Traditional sutures for wound closure pose challenges like lengthy procedures and scar formation, especially in diabetic patients. This study presents a novel injectable hydrogel, PGHAA (borated peach gum polysaccharide and oxime hyaluronic acid), designed to enhance diabetic wound healing. Incorporating arginine for angiogenesis and using natural polysaccharides, PGHAA exhibits superior adhesion, biocompatibility, and immunoregulation. In vivo tests on diabetic rats demonstrate that PGHAA accelerates wound closure, reduces inflammation, and enhances collagen deposition and angiogenesis. Molecular dynamics simulations reveal self-healing mechanisms, while transcriptome analysis shows the activation of IL-17 pathways, promoting skin regeneration. PGHAA hydrogels significantly advance chronic wound treatment.
| Published in | Abstract Book of MEDLIFE2025 & ICBLS2025 |
| Page(s) | 11-11 |
| Creative Commons |
This is an Open Access abstract, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Injectable Hydrogel, Diabetic Wound Healing, Angiogenesis, Biocompatibility, Self-Healing
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