Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats

Odukanmi Olugbenga Adeola

doi:doi:10.11648/j.ajbls.20221002.18

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Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats

Odukanmi Olugbenga Adeola

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 2)

Received: 23 March 2022 Accepted: 7 April 2022 Published: 26 April 2022

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Abstract

Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.

Published in	American Journal of Biomedical and Life Sciences (Volume 10, Issue 2)
DOI	10.11648/j.ajbls.20221002.18
Page(s)	49-54
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes, Gastrointestinal Motility, Gastric Emptying, Intestinal Propulsion, Colonic Motility, Postprandial Hyperglycemia

References

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Odukanmi Olugbenga Adeola. (2022). Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. American Journal of Biomedical and Life Sciences, 10(2), 49-54. https://doi.org/10.11648/j.ajbls.20221002.18

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ACS Style

Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am. J. Biomed. Life Sci. 2022, 10(2), 49-54. doi: 10.11648/j.ajbls.20221002.18

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AMA Style

Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am J Biomed Life Sci. 2022;10(2):49-54. doi: 10.11648/j.ajbls.20221002.18

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@article{10.11648/j.ajbls.20221002.18,
  author = {Odukanmi Olugbenga Adeola},
  title = {Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {2},
  pages = {49-54},
  doi = {10.11648/j.ajbls.20221002.18},
  url = {https://doi.org/10.11648/j.ajbls.20221002.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221002.18},
  abstract = {Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.},
 year = {2022}
}

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TY - JOUR
T1 - Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats
AU - Odukanmi Olugbenga Adeola
Y1 - 2022/04/26
PY - 2022
N1 - https://doi.org/10.11648/j.ajbls.20221002.18
DO - 10.11648/j.ajbls.20221002.18
T2 - American Journal of Biomedical and Life Sciences
JF - American Journal of Biomedical and Life Sciences
JO - American Journal of Biomedical and Life Sciences
SP - 49
EP - 54
PB - Science Publishing Group
SN - 2330-880X
UR - https://doi.org/10.11648/j.ajbls.20221002.18
AB - Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.
VL - 10
IS - 2
ER -

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Odukanmi Olugbenga Adeola

Laboratory for Gastrointestinal Secretions and Inflammation, Department of Physiology, University of Ibadan, Ibadan, Nigeria

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Odukanmi Olugbenga Adeola. (2022). Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. American Journal of Biomedical and Life Sciences, 10(2), 49-54. https://doi.org/10.11648/j.ajbls.20221002.18

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ACS Style

Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am. J. Biomed. Life Sci. 2022, 10(2), 49-54. doi: 10.11648/j.ajbls.20221002.18

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AMA Style

Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am J Biomed Life Sci. 2022;10(2):49-54. doi: 10.11648/j.ajbls.20221002.18

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@article{10.11648/j.ajbls.20221002.18,
  author = {Odukanmi Olugbenga Adeola},
  title = {Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {2},
  pages = {49-54},
  doi = {10.11648/j.ajbls.20221002.18},
  url = {https://doi.org/10.11648/j.ajbls.20221002.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221002.18},
  abstract = {Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.},
 year = {2022}
}

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