Background: Sarcoidosis can affect virtually any organ of the body, primarily the lungs, lymphatic system, skin or eyes, or a combination of these sites and it is characterized by the formation of non-caseating granulomas. Muscular involvement in sarcoidosis is usually asymptomatic or pauci-symptomatic, and its nodular form is exceptional. Observation: In this study, we report the case of a 36-year-old man who had been presenting with nodules in both calves for about two years which onset was progressive. These nodules were painless and deeply embedded in the gastrocnemius muscles. There were no functional complaints, and the general condition was preserved. The physical examination, especially at skin level was free of other clinical signs except the nodules. The PET-scan (positron emission tomography) revealed a few discretely hypermetabolic cervico-axillary lymph nodes and multiple bilateral mediastino-hilar adenopathies involving all lymph nodes, as well as multiple bilateral hypermetabolic pulmonary foci. Biopsy of accessory salivary glands (BASG) exhibited an epithelioid and gigantocellular granuloma without necrosis that confirm the diagnosis of systemic sarcoidosis. The search for another location, notably cardiac, ophthalmological, neurological, or renal, was negative. The respiratory function tests did not show any restrictive syndrome or abnormalities in the DLCO/VA ratio. It was therefore a systemic sarcoidosis with mediastino-pulmonary stage II, diffuse lymph node, splenic, and muscle involvement. Conclusion: This case shows the importance of BASG in the diagnosis of muscular sarcoidosis, in case of impossibility of performing a muscle biopsy.
| Published in | American Journal of Internal Medicine (Volume 11, Issue 1) |
| DOI | 10.11648/j.ajim.20231101.12 |
| Page(s) | 5-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Muscular Nodules, PET Scan, Sarcoidosis, Dijon
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APA Style
Finangnon Armand Wanvoegbe, Alin Turcu, Herve Devilliers, Romain Bouvet, Suzanne Mouries-Martin, et al. (2023). A Rare Presentation of Muscle Involvement in Sarcoidosis: A Case Report. American Journal of Internal Medicine, 11(1), 5-7. https://doi.org/10.11648/j.ajim.20231101.12
ACS Style
Finangnon Armand Wanvoegbe; Alin Turcu; Herve Devilliers; Romain Bouvet; Suzanne Mouries-Martin, et al. A Rare Presentation of Muscle Involvement in Sarcoidosis: A Case Report. Am. J. Intern. Med. 2023, 11(1), 5-7. doi: 10.11648/j.ajim.20231101.12
AMA Style
Finangnon Armand Wanvoegbe, Alin Turcu, Herve Devilliers, Romain Bouvet, Suzanne Mouries-Martin, et al. A Rare Presentation of Muscle Involvement in Sarcoidosis: A Case Report. Am J Intern Med. 2023;11(1):5-7. doi: 10.11648/j.ajim.20231101.12
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Download@article{10.11648/j.ajim.20231101.12,
author = {Finangnon Armand Wanvoegbe and Alin Turcu and Herve Devilliers and Romain Bouvet and Suzanne Mouries-Martin and Geraldine Muller and Marion Laboz and Kouessi Anthelme Agbodande and Angele Azon-Kouanou and Philip Bielefeld and Jean-François Besancenot},
title = {A Rare Presentation of Muscle Involvement in Sarcoidosis: A Case Report},
journal = {American Journal of Internal Medicine},
volume = {11},
number = {1},
pages = {5-7},
doi = {10.11648/j.ajim.20231101.12},
url = {https://doi.org/10.11648/j.ajim.20231101.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20231101.12},
abstract = {Background: Sarcoidosis can affect virtually any organ of the body, primarily the lungs, lymphatic system, skin or eyes, or a combination of these sites and it is characterized by the formation of non-caseating granulomas. Muscular involvement in sarcoidosis is usually asymptomatic or pauci-symptomatic, and its nodular form is exceptional. Observation: In this study, we report the case of a 36-year-old man who had been presenting with nodules in both calves for about two years which onset was progressive. These nodules were painless and deeply embedded in the gastrocnemius muscles. There were no functional complaints, and the general condition was preserved. The physical examination, especially at skin level was free of other clinical signs except the nodules. The PET-scan (positron emission tomography) revealed a few discretely hypermetabolic cervico-axillary lymph nodes and multiple bilateral mediastino-hilar adenopathies involving all lymph nodes, as well as multiple bilateral hypermetabolic pulmonary foci. Biopsy of accessory salivary glands (BASG) exhibited an epithelioid and gigantocellular granuloma without necrosis that confirm the diagnosis of systemic sarcoidosis. The search for another location, notably cardiac, ophthalmological, neurological, or renal, was negative. The respiratory function tests did not show any restrictive syndrome or abnormalities in the DLCO/VA ratio. It was therefore a systemic sarcoidosis with mediastino-pulmonary stage II, diffuse lymph node, splenic, and muscle involvement. Conclusion: This case shows the importance of BASG in the diagnosis of muscular sarcoidosis, in case of impossibility of performing a muscle biopsy.},
year = {2023}
}
TY - JOUR T1 - A Rare Presentation of Muscle Involvement in Sarcoidosis: A Case Report AU - Finangnon Armand Wanvoegbe AU - Alin Turcu AU - Herve Devilliers AU - Romain Bouvet AU - Suzanne Mouries-Martin AU - Geraldine Muller AU - Marion Laboz AU - Kouessi Anthelme Agbodande AU - Angele Azon-Kouanou AU - Philip Bielefeld AU - Jean-François Besancenot Y1 - 2023/01/31 PY - 2023 N1 - https://doi.org/10.11648/j.ajim.20231101.12 DO - 10.11648/j.ajim.20231101.12 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 5 EP - 7 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20231101.12 AB - Background: Sarcoidosis can affect virtually any organ of the body, primarily the lungs, lymphatic system, skin or eyes, or a combination of these sites and it is characterized by the formation of non-caseating granulomas. Muscular involvement in sarcoidosis is usually asymptomatic or pauci-symptomatic, and its nodular form is exceptional. Observation: In this study, we report the case of a 36-year-old man who had been presenting with nodules in both calves for about two years which onset was progressive. These nodules were painless and deeply embedded in the gastrocnemius muscles. There were no functional complaints, and the general condition was preserved. The physical examination, especially at skin level was free of other clinical signs except the nodules. The PET-scan (positron emission tomography) revealed a few discretely hypermetabolic cervico-axillary lymph nodes and multiple bilateral mediastino-hilar adenopathies involving all lymph nodes, as well as multiple bilateral hypermetabolic pulmonary foci. Biopsy of accessory salivary glands (BASG) exhibited an epithelioid and gigantocellular granuloma without necrosis that confirm the diagnosis of systemic sarcoidosis. The search for another location, notably cardiac, ophthalmological, neurological, or renal, was negative. The respiratory function tests did not show any restrictive syndrome or abnormalities in the DLCO/VA ratio. It was therefore a systemic sarcoidosis with mediastino-pulmonary stage II, diffuse lymph node, splenic, and muscle involvement. Conclusion: This case shows the importance of BASG in the diagnosis of muscular sarcoidosis, in case of impossibility of performing a muscle biopsy. VL - 11 IS - 1 ER -
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