Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou

Finangnon Armand Wanvoegbe; Aboudou Raïmi Kpossou; Kouessi Anthelme Agbodande; Cossi Angelo Attinsounon; Corinne Flore Kouam Kamdem; Rodolphe Vignon; Martin Sokpon; Angele Azon-Kouanou; Jean Sehonou; Daniel Amoussou-Guenou; Djimon Marcel Zannou

doi:doi:10.11648/j.ajim.20231101.14

Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou

Finangnon Armand Wanvoegbe, Aboudou Raïmi Kpossou, Kouessi Anthelme Agbodande, Cossi Angelo Attinsounon, Corinne Flore Kouam Kamdem, Rodolphe Vignon, Martin Sokpon, Angele Azon-Kouanou, Jean Sehonou, Daniel Amoussou-Guenou, Djimon Marcel Zannou

Published in American Journal of Internal Medicine (Volume 11, Issue 1)

Received: 2 February 2023 Accepted: 28 February 2023 Published: 9 March 2023

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Abstract

Background: Chronic hepatitis C virus (HCV) infection induces the occurence of severe chronic liver disease and metabolic complications. Our goal was to study the clinical and paraclinical profile of patients with hepatitis C virus at the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou. Methods: This was a cross-sectional and descriptive study conducted at the Teaching Clinic of Hepato-Gastroenterology of the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou with the treated patients, from January 1, 2012, to October 31, 2018. Results: A total of 80 patients with hepatitis C were included in the study. The mean age was 60.2 ± 10.8 years old with extremes of 34 and 84 years. Most of the subjects surveyed were women (62.5%) with a sex ratio of 0.6. Arterial hypertension was the prevalent history in these patients (61.2%). HCV carriage was known for less than 5 years in 70% of cases. The most represented genotype was viral genotype 2 (57.2%). Complications were noted in 47.5% of respondents, dominated by cirrhosis (40%). FibroTest was the main method of non-invasive evaluation of fibrosis. Conclusion: In our study, hepatitis C affects mostly women. It is often diagnosed late. Hence, there is a real need to reinforce awareness.

Published in	American Journal of Internal Medicine (Volume 11, Issue 1)
DOI	10.11648/j.ajim.20231101.14
Page(s)	12-15
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cirrhosis, Viral Hepatitis C, Cotonou, Benin

References

[1]	World Health Organization. Global hepatitis report 2017, Geneva, WHO, 2017, 83 p.
[2]	Hutin Y, Kitler M, Dore G, Perz JF, Armstrong GL, Dusheiko G et al. Global Burden of Disease (GBD) for hepatitis C. The Journal of Clinical Pharmacology 2004; 44 (1): 20-9.
[3]	Kodjoh N. Status of hepatitis B and C control in Africa. Méd Santé Trop. 2015; 25: 141-144.
[4]	Knobler H, Schattner A. TNF α chronic hepatitis C and diabetes. a novel triad Physicians. 2005; 98: 1-6.
[5]	Kpossou AR, Séhonou J, Wanvoegbe FA, Abattan C, Sokpon CNM, Vignon RK. Viral hepatitis B and C: epidemiological and clinical aspects at the National Hospital and University Center of Cotonou. Médecine d’Afrique Noire 2019; 66 (1): 5-12.
[6]	Kodjoh N, Latoundji SB, Kpossou AR, Sake AK, Vignon R, Houinato D. Knowledge and beliefs of patients regarding chronic hepatitis B and C in the Republic of Benin. J. Afr. Hépatol. Gastroentérol. 2014; 9 (1): 2-6.
[7]	Elhawary EI, Mahmoud GF, El-Daly MA, Mekky FA, Esmat GG, Abdel-hamid M. Association of HCV with diabetes mellitus: an Egyptian case–control study. Virol J. 2011; 1-8.
[8]	Bassit N. Seroprevalence of hepatitis C virus infection in type 2 diabetics [Med Thesis]. Morocco: Cadi Ayyad University Faculty of Medicine and Pharmacy Marrakech, 2014, N°24, 111 p.
[9]	Simo R, Hernandez C, Genesca J, Jardí R, Mesa J. High prevalence of hepatitis C virus infection in diabetic patients. Diabetes Care. 1996; 19: 998–1000.
[10]	Ndako JA, Echeonwu GO, Shidali NN, Bichi IA, Paul GA, Onovoh E et al. Occurrence of hepatitis C virus infection in type 2 diabetic patients attending Plateau state specialist hospital Jos Nigeria. Virol J. 2009; 6 (1): 98. doi.org/10.1186/1743-422x-6-98.
[11]	Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS et al. The role of parentral antischistosomal therapy in the spread of HCV in Egypt. Lancet. 2000; 355: 887-91.
[12]	Kpossou AR, Wanvoegbe FA, Abattan CGLM, Vignon RK, Sokpon CNM, Sehonou J. Viral hepatitis B and C: Paraclinical and evolutionary aspects at the National Hospital and University Center of Cotonou. Les Annales de l’Université de Parakou, Série "Sciences de la Santé" 2020; 10 (1): 10-13.
[13]	Chevaliez S, Brillet R, Sehonou J, Barbotte L, Pawlotsky JM. Outbreak of a new hepatitis C virus subtype (subtype 1m) in a hemodialysis unit: how new HCV genotypes start their spread. Journal of Hepatology. 2008; 48 (Suppl 2): S270–S271. doi.org/10.1016/S0168-8278(08)60726-6.
[14]	Ray SC, Arthur RR, Carella A, Bukh J, Thomas DL. Genetic epidemiology of HCV throughout Egypt. J Infect Dis. 2000, 182: 698-707.
[15]	Touiti A. Epidemiological profile of viral B cirrhosis (about 50 cases) [Med Thesis]. Marrakesh: Cadi Ayyad University, 2009, N° 87, 113p.

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Finangnon Armand Wanvoegbe, Aboudou Raïmi Kpossou, Kouessi Anthelme Agbodande, Cossi Angelo Attinsounon, Corinne Flore Kouam Kamdem, et al. (2023). Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. American Journal of Internal Medicine, 11(1), 12-15. https://doi.org/10.11648/j.ajim.20231101.14

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ACS Style

Finangnon Armand Wanvoegbe; Aboudou Raïmi Kpossou; Kouessi Anthelme Agbodande; Cossi Angelo Attinsounon; Corinne Flore Kouam Kamdem, et al. Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. Am. J. Intern. Med. 2023, 11(1), 12-15. doi: 10.11648/j.ajim.20231101.14

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AMA Style

Finangnon Armand Wanvoegbe, Aboudou Raïmi Kpossou, Kouessi Anthelme Agbodande, Cossi Angelo Attinsounon, Corinne Flore Kouam Kamdem, et al. Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. Am J Intern Med. 2023;11(1):12-15. doi: 10.11648/j.ajim.20231101.14

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@article{10.11648/j.ajim.20231101.14,
  author = {Finangnon Armand Wanvoegbe and Aboudou Raïmi Kpossou and Kouessi Anthelme Agbodande and Cossi Angelo Attinsounon and Corinne Flore Kouam Kamdem and Rodolphe Vignon and Martin Sokpon and Angele Azon-Kouanou and Jean Sehonou and Daniel Amoussou-Guenou and Djimon Marcel Zannou},
  title = {Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou},
  journal = {American Journal of Internal Medicine},
  volume = {11},
  number = {1},
  pages = {12-15},
  doi = {10.11648/j.ajim.20231101.14},
  url = {https://doi.org/10.11648/j.ajim.20231101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20231101.14},
  abstract = {Background: Chronic hepatitis C virus (HCV) infection induces the occurence of severe chronic liver disease and metabolic complications. Our goal was to study the clinical and paraclinical profile of patients with hepatitis C virus at the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou. Methods: This was a cross-sectional and descriptive study conducted at the Teaching Clinic of Hepato-Gastroenterology of the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou with the treated patients, from January 1, 2012, to October 31, 2018. Results: A total of 80 patients with hepatitis C were included in the study. The mean age was 60.2 ± 10.8 years old with extremes of 34 and 84 years. Most of the subjects surveyed were women (62.5%) with a sex ratio of 0.6. Arterial hypertension was the prevalent history in these patients (61.2%). HCV carriage was known for less than 5 years in 70% of cases. The most represented genotype was viral genotype 2 (57.2%). Complications were noted in 47.5% of respondents, dominated by cirrhosis (40%). FibroTest was the main method of non-invasive evaluation of fibrosis. Conclusion: In our study, hepatitis C affects mostly women. It is often diagnosed late. Hence, there is a real need to reinforce awareness.},
 year = {2023}
}

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TY - JOUR
T1 - Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou
AU - Finangnon Armand Wanvoegbe
AU - Aboudou Raïmi Kpossou
AU - Kouessi Anthelme Agbodande
AU - Cossi Angelo Attinsounon
AU - Corinne Flore Kouam Kamdem
AU - Rodolphe Vignon
AU - Martin Sokpon
AU - Angele Azon-Kouanou
AU - Jean Sehonou
AU - Daniel Amoussou-Guenou
AU - Djimon Marcel Zannou
Y1 - 2023/03/09
PY - 2023
N1 - https://doi.org/10.11648/j.ajim.20231101.14
DO - 10.11648/j.ajim.20231101.14
T2 - American Journal of Internal Medicine
JF - American Journal of Internal Medicine
JO - American Journal of Internal Medicine
SP - 12
EP - 15
PB - Science Publishing Group
SN - 2330-4324
UR - https://doi.org/10.11648/j.ajim.20231101.14
AB - Background: Chronic hepatitis C virus (HCV) infection induces the occurence of severe chronic liver disease and metabolic complications. Our goal was to study the clinical and paraclinical profile of patients with hepatitis C virus at the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou. Methods: This was a cross-sectional and descriptive study conducted at the Teaching Clinic of Hepato-Gastroenterology of the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou with the treated patients, from January 1, 2012, to October 31, 2018. Results: A total of 80 patients with hepatitis C were included in the study. The mean age was 60.2 ± 10.8 years old with extremes of 34 and 84 years. Most of the subjects surveyed were women (62.5%) with a sex ratio of 0.6. Arterial hypertension was the prevalent history in these patients (61.2%). HCV carriage was known for less than 5 years in 70% of cases. The most represented genotype was viral genotype 2 (57.2%). Complications were noted in 47.5% of respondents, dominated by cirrhosis (40%). FibroTest was the main method of non-invasive evaluation of fibrosis. Conclusion: In our study, hepatitis C affects mostly women. It is often diagnosed late. Hence, there is a real need to reinforce awareness.
VL - 11
IS - 1
ER -

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Author Information

Finangnon Armand Wanvoegbe

Internal Medicine Department, Oueme-Plateau Departmental Teaching Hospital, Porto-Novo, Benin
Aboudou Raïmi Kpossou
Kouessi Anthelme Agbodande

Internal Medicine Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin
Cossi Angelo Attinsounon

Internal Medicine Department, Borgou-Alibori Departmental Teaching Hospital, Parakou, Benin
Corinne Flore Kouam Kamdem

Internal Medicine Department, Oueme-Plateau Departmental Teaching Hospital, Porto-Novo, Benin
Rodolphe Vignon

Hepato-Gastroenterology Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin
Martin Sokpon

Hepato-Gastroenterology Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin
Angele Azon-Kouanou

Internal Medicine Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin
Jean Sehonou

Hepato-Gastroenterology Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin
Daniel Amoussou-Guenou

Internal Medicine Department, Oueme-Plateau Departmental Teaching Hospital, Porto-Novo, Benin
Djimon Marcel Zannou

Internal Medicine Department, Natioanl Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin

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APA Style

Finangnon Armand Wanvoegbe, Aboudou Raïmi Kpossou, Kouessi Anthelme Agbodande, Cossi Angelo Attinsounon, Corinne Flore Kouam Kamdem, et al. (2023). Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. American Journal of Internal Medicine, 11(1), 12-15. https://doi.org/10.11648/j.ajim.20231101.14

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Finangnon Armand Wanvoegbe; Aboudou Raïmi Kpossou; Kouessi Anthelme Agbodande; Cossi Angelo Attinsounon; Corinne Flore Kouam Kamdem, et al. Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. Am. J. Intern. Med. 2023, 11(1), 12-15. doi: 10.11648/j.ajim.20231101.14

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AMA Style

Finangnon Armand Wanvoegbe, Aboudou Raïmi Kpossou, Kouessi Anthelme Agbodande, Cossi Angelo Attinsounon, Corinne Flore Kouam Kamdem, et al. Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou. Am J Intern Med. 2023;11(1):12-15. doi: 10.11648/j.ajim.20231101.14

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@article{10.11648/j.ajim.20231101.14,
  author = {Finangnon Armand Wanvoegbe and Aboudou Raïmi Kpossou and Kouessi Anthelme Agbodande and Cossi Angelo Attinsounon and Corinne Flore Kouam Kamdem and Rodolphe Vignon and Martin Sokpon and Angele Azon-Kouanou and Jean Sehonou and Daniel Amoussou-Guenou and Djimon Marcel Zannou},
  title = {Clinical and Paraclinical Profiles of Patients with Viral Hepatitis C in Cotonou},
  journal = {American Journal of Internal Medicine},
  volume = {11},
  number = {1},
  pages = {12-15},
  doi = {10.11648/j.ajim.20231101.14},
  url = {https://doi.org/10.11648/j.ajim.20231101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20231101.14},
  abstract = {Background: Chronic hepatitis C virus (HCV) infection induces the occurence of severe chronic liver disease and metabolic complications. Our goal was to study the clinical and paraclinical profile of patients with hepatitis C virus at the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou. Methods: This was a cross-sectional and descriptive study conducted at the Teaching Clinic of Hepato-Gastroenterology of the Natioanl Teaching Hospital Hubert Koutoukou Maga of Cotonou with the treated patients, from January 1, 2012, to October 31, 2018. Results: A total of 80 patients with hepatitis C were included in the study. The mean age was 60.2 ± 10.8 years old with extremes of 34 and 84 years. Most of the subjects surveyed were women (62.5%) with a sex ratio of 0.6. Arterial hypertension was the prevalent history in these patients (61.2%). HCV carriage was known for less than 5 years in 70% of cases. The most represented genotype was viral genotype 2 (57.2%). Complications were noted in 47.5% of respondents, dominated by cirrhosis (40%). FibroTest was the main method of non-invasive evaluation of fibrosis. Conclusion: In our study, hepatitis C affects mostly women. It is often diagnosed late. Hence, there is a real need to reinforce awareness.},
 year = {2023}
}

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