Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria

Nkemegbunam Okoli; Boma Oyan; Sunny Chinenye; Chioma Unachukwu; Okechukwu Iheji

doi:doi:10.11648/j.ajim.20231102.11

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Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria

Nkemegbunam Okoli, Boma Oyan, Sunny Chinenye, Chioma Unachukwu, Okechukwu Iheji

Published in American Journal of Internal Medicine (Volume 11, Issue 2)

Received: 7 March 2023 Accepted: 1 April 2023 Published: 15 April 2023

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Abstract

Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value <0.05. Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ²=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.

Published in	American Journal of Internal Medicine (Volume 11, Issue 2)
DOI	10.11648/j.ajim.20231102.11
Page(s)	22-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pre-Diabetes, First Degree Relatives, Type 2 Diabetes, Nigeria

References

[1]	National Diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Centers for Disease Control and Prevention (CDC). 2012. Cited January 5 2023. Available from http://www.cdc.gov/diabetes/prevention/about.htm.
[2]	Aroda VR, Ratner R. Approach to the patient with prediabetes. J Clin Endocrinol Metab. 2008; 93 (9): 3259-3265. doi: 10.1210/jc.2008-1091.
[3]	Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes. 2000; 49 (12): 2201-2207. doi: 10.2337/diabetes.49.12.2201.
[4]	Genuth S, Alberti KG, Bennett P, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003; 26 (11): 3160-3167. doi: 10.2337/diacare.26.11.3160.
[5]	American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010 Jan; 33 Suppl 1 (Suppl 1): S62-9. doi: 10.2337/dc10-S062. Erratum in: Diabetes Care. 2010 Apr; 33 (4): e57. PMID: 20042775; PMCID: PMC2797383.
[6]	Santaguida PL, Balion C, Hunt D, et al. Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose. Evid Rep Technol Assess (Summ). 2005; (128): 1-11.
[7]	American Diabetes Association. Standards of medical care in diabetes--2013. Diabetes Care. 2013 Jan; 36 Suppl 1 (Suppl 1): S11-66. doi: 10.2337/dc13-S011. PMID: 23264422; PMCID: PMC3537269.
[8]	Stadler, M., Pacini, G., Petrie, J. et al. Beta cell (dys) function in non-diabetic offspring of diabetic patients. Diabetologia 52, 2435–2444 (2009). https://doi.org/10.1007/s00125-009-1520-7
[9]	Beck-Nielsen H, Groop LC. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J Clin Invest. 1994; 94 (5): 1714-1721. doi: 10.1172/JCI117518.
[10]	Granner DK, O'Brien RM. Molecular physiology and genetics of NIDDM. Importance of metabolic staging. Diabetes Care. 1992; 15 (3): 369-395. doi: 10.2337/diacare.15.3.369.
[11]	Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992; 340 (8825): 925-929. doi: 10.1016/0140-6736(92)92814-v.
[12]	Eriksson J, Franssila-Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med. 1989; 321 (6): 337-343. doi: 10.1056/NEJM198908103210601.
[13]	Wagner R, Thorand B, Osterhoff MA, et al. Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research. Diabetologia. 2013; 56 (10): 2176-2180. doi: 10.1007/s00125-013-3002-1.
[14]	Ezenwaka CE, Akanji AO, Osei K, et al. Glucose and insulin responses to intravenous glucose challenge in relatives of Nigerian patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1993; 20 (3): 175-181. doi: 10.1016/0168-8227(93)90075-g.
[15]	InterAct Consortium, Scott RA, Langenberg C, et al. The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study. Diabetologia. 2013; 56 (1): 60-69. doi: 10.1007/s00125-012-2715-x.
[16]	Oyegbade OO, Abioye-Kuteyi EA, Kolawole BA, Ezeoma IT, Bello IS. Screening for Diabetes Mellitus in a Nigerian Family Practice Population. SA Fam Pract. 2007, 49; 8: 15-18. doi: 10.1080/20786204.2007.10873612.
[17]	Chinenye S, Onyemelukwe GC, Johnson TO, Oputa RN, Oluwasanu M. Diabetes Advocacy and Care in Nigeria. Port Harcourt, Nigeria: Diabetes Association of Nigeria; 2014: 139-145.
[18]	WHO Expert Committee on Physical Status: The use and Interpretation of Anthropometry (‎1993: Geneva, Switzerland)‎ & World Health Organization. (‎1995)‎. Physical status: the use of and interpretation of anthropometry, report of a WHO expert committee. World Health Organization. https://apps.who.int/iris/handle/10665/37003
[19]	National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002; 106 (25): 3143-3421.
[20]	Asha Shrivastava, Namit Garg, & Rashmi Dave. (2013). HbA1c: Future Diabetic And Cardiovascular Risk In First Degree Relatives Of Type 2 Diabetes Mellitus. International Journal of Basic and Applied Physiology, 2 (1), 79–82. https://doi.org/10.5281/zenodo.4483066
[21]	Karaman A, Bayram F, Gundogan K, Ozsan M, Karaman H, Kelestimur F. Prevalence of diabetes mellitus and glucose metabolism disorders in the first degree relatives of type 2 diabetic patients. Bratisl Lek Listy. 2012; 113 (6): 361-367. doi: 10.4149/bll_2012_082.
[22]	Amini M, Janghorbani M. Diabetes and impaired glucose regulation in first-degree relatives of patients with type 2 diabetes in isfahan, iran: prevalence and risk factors. Rev Diabet Stud. 2007 Fall; 4 (3): 169-76. doi: 10.1900/RDS.2007.4.169. Epub 2007 Nov 10. PMID: 18084674; PMCID: PMC2174064.
[23]	Nyenwe EA, Odia OJ, Ihekwaba AE, Ojule A, Babatunde S. Type 2 diabetes in adult Nigerians: a study of its prevalence and risk factors in Port Harcourt, Nigeria. Diabetes Res Clin Pract. 2003; 62 (3): 177-185. doi: 10.1016/j.diabres.2003.07.002.
[24]	Ogbu I, Neboh CI. The prevalence of Prediabetes among hypertensive patients in Enugu, Southeast Nigeria. Niger Med J 2009; 50: 14-17. doi: https://www.nigeriamedj.com/text.asp?2009/50/1/14/71931
[25]	Erasmus RT, Blanco Blanco E, Okesina AB, Mesa Arana J, Gqweta Z, Matsha T. Importance of family history in type 2 black South African diabetic patients. Postgrad Med J. 2001 May; 77 (907): 323-5. doi: 10.1136/pmj.77.907.323. PMID: 11320276; PMCID: PMC1742028.
[26]	Ogah OS. Hypertension in Sub-Saharan African populations: the burden of hypertension in Nigeria. Ethn Dis. 2006; 16 (4): 765.
[27]	Chukwuonye II, Chuku A, John C, Ohagwu KA, Imoh ME, Isa SE, Ogah OS, Oviasu E. Prevalence of overweight and obesity in adult Nigerians - a systematic review. Diabetes Metab Syndr Obes. 2013; 6: 43-7. doi: 10.2147/DMSO.S38626. Epub 2013 Jan 22. PMID: 23573067; PMCID: PMC3556860.
[28]	Soltanian NA, Amini B I, Askari G, Ebneyamin S, Ghias M, Hajian H. et al. Weight status of the first-degree relatives of patients with type 2 diabetes based on the glucose tolerance test. Journal of Research in Medical Sciences. 2012; 17 (3): 269-270. doi: .
[29]	Montague CT, O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes. 2000; 49 (6): 883-888. doi: 10.2337/diabetes.49.6.883.
[30]	Adeleye J. O, Abiyesuku F. M. Anthropometric Characteristics of offspring of Nigerian type 2 Diabetics. Niger J Clin Pract. 2004; 5: 75-80.
[31]	Ogedengbe SO, Ezeani IU. Profile of metabolic abnormalities seen in patients with type 2 diabetes mellitus and their first degree relatives with metabolic syndrome seen in Benin City, Edo state Nigeria. J Diabetes Metab Disord. 2014; 13: 61. Published 2014 May 23. doi: 10.1186/2251-6581-13-61.

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APA Style

Nkemegbunam Okoli, Boma Oyan, Sunny Chinenye, Chioma Unachukwu, Okechukwu Iheji. (2023). Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. American Journal of Internal Medicine, 11(2), 22-28. https://doi.org/10.11648/j.ajim.20231102.11

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ACS Style

Nkemegbunam Okoli; Boma Oyan; Sunny Chinenye; Chioma Unachukwu; Okechukwu Iheji. Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. Am. J. Intern. Med. 2023, 11(2), 22-28. doi: 10.11648/j.ajim.20231102.11

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AMA Style

Nkemegbunam Okoli, Boma Oyan, Sunny Chinenye, Chioma Unachukwu, Okechukwu Iheji. Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. Am J Intern Med. 2023;11(2):22-28. doi: 10.11648/j.ajim.20231102.11

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@article{10.11648/j.ajim.20231102.11,
  author = {Nkemegbunam Okoli and Boma Oyan and Sunny Chinenye and Chioma Unachukwu and Okechukwu Iheji},
  title = {Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria},
  journal = {American Journal of Internal Medicine},
  volume = {11},
  number = {2},
  pages = {22-28},
  doi = {10.11648/j.ajim.20231102.11},
  url = {https://doi.org/10.11648/j.ajim.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20231102.11},
  abstract = {Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ2=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.},
 year = {2023}
}

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TY  - JOUR
T1  - Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria
AU  - Nkemegbunam Okoli
AU  - Boma Oyan
AU  - Sunny Chinenye
AU  - Chioma Unachukwu
AU  - Okechukwu Iheji
Y1  - 2023/04/15
PY  - 2023
N1  - https://doi.org/10.11648/j.ajim.20231102.11
DO  - 10.11648/j.ajim.20231102.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 22
EP  - 28
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20231102.11
AB  - Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ2=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.
VL  - 11
IS  - 2
ER  -

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Author Information

Nkemegbunam Okoli

Department of Internal Medicine, National Orthopaedic Hospital, Igbobi, Nigeria
Boma Oyan

Department of Internal Medicine, Rivers State University Teaching Hospital, Port Harcourt, Nigeria
Sunny Chinenye

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
Chioma Unachukwu

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
Okechukwu Iheji

Department of Internal Medicine, Federal Medical Centre, Umuahia, Nigeria

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APA Style

Nkemegbunam Okoli, Boma Oyan, Sunny Chinenye, Chioma Unachukwu, Okechukwu Iheji. (2023). Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. American Journal of Internal Medicine, 11(2), 22-28. https://doi.org/10.11648/j.ajim.20231102.11

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ACS Style

Nkemegbunam Okoli; Boma Oyan; Sunny Chinenye; Chioma Unachukwu; Okechukwu Iheji. Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. Am. J. Intern. Med. 2023, 11(2), 22-28. doi: 10.11648/j.ajim.20231102.11

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AMA Style

Nkemegbunam Okoli, Boma Oyan, Sunny Chinenye, Chioma Unachukwu, Okechukwu Iheji. Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria. Am J Intern Med. 2023;11(2):22-28. doi: 10.11648/j.ajim.20231102.11

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@article{10.11648/j.ajim.20231102.11,
  author = {Nkemegbunam Okoli and Boma Oyan and Sunny Chinenye and Chioma Unachukwu and Okechukwu Iheji},
  title = {Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria},
  journal = {American Journal of Internal Medicine},
  volume = {11},
  number = {2},
  pages = {22-28},
  doi = {10.11648/j.ajim.20231102.11},
  url = {https://doi.org/10.11648/j.ajim.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20231102.11},
  abstract = {Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ2=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.},
 year = {2023}
}

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TY  - JOUR
T1  - Prevalence of Prediabetes in First Degree Relatives of Patients with Type 2 Diabetes Mellitus in a Tertiary Centre in Southern Nigeria
AU  - Nkemegbunam Okoli
AU  - Boma Oyan
AU  - Sunny Chinenye
AU  - Chioma Unachukwu
AU  - Okechukwu Iheji
Y1  - 2023/04/15
PY  - 2023
N1  - https://doi.org/10.11648/j.ajim.20231102.11
DO  - 10.11648/j.ajim.20231102.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 22
EP  - 28
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20231102.11
AB  - Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ2=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.
VL  - 11
IS  - 2
ER  -

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