@article{10.11648/j.ajnhs.20220303.15,
  author = {Wubakal Teshome and Tesfaye Dagne and Tsegaye Getachew},
  title = {Assessing the Predictors and Outcomes of Guillain-Barré Syndrome at St. Paul’s and Zewditu Hospitals in Addis Ababa, Ethiopia},
  journal = {American Journal of Nursing and Health Sciences},
  volume = {3},
  number = {3},
  pages = {73-83},
  doi = {10.11648/j.ajnhs.20220303.15},
  url = {https://doi.org/10.11648/j.ajnhs.20220303.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajnhs.20220303.15},
  abstract = {Guillain–Barré Syndrome (GBS) is the most frequent cause of acute flaccid paralysis worldwide and constitute one of serious emergencies in neurology. In Ethiopia there is high prevalence of infectious disease influencing the prevalence as well as the subsequent outcome of GBS where there is significant constrain in the availability of critical care, rehabilitation and social service. So, the objective of this study is assessing predictors and outcomes of Guillain-Barré Syndrome. Retrospective cross sectional study was used and all patients who fulfill the inclusion criteria’s for GBS in the 7 years period were included. The organized data was interpreted using descriptive methods in the form of tables, charts, and graphs in the SPSS version 20 and Excel software. Binary logistic regression analysis was used to assess the association between exposure variables and outcome of GBS. And univariate analysis performed to screen out potentially significant independent variables to be included in the multivariable binary logistic regression. The most common presenting symptoms were muscle weakness (91), respiratory muscle involvement (32) and Cranial Nerve involvement (27). HIV (40.64%) and DM (31.25%) were important comorbid illness. Cranial nerve palsies, respiratory compromise, disability score, need of mechanical ventilation, HIV and DM were significantly associated with worse outcome. Common GBS variants identified were AMAN (36%) and AIDP (30%), AMAN type were associated with unfortunate outcome. GBS-specific therapy was administered in 43.96% patients and having appropriate treatment had lower incidence of poor outcome. Generally, this study showed 60% of patients had good outcome (GDS ≤ 2) and 40% of bad outcome (GDS > 2). Digitization of medical recording evaluation report using a software based template would help to improve the completeness of each patient report and awareness of predictors of GBS outcome and being perceptive for alarming features will help allocate resource in keen manner in our resource restricted setting. Having GBS specific treatments available in affordable and accessible manner will inflict significant light in the prognosis of GBS patients. It would be better to conduct further studies on Concordance between molecular tests, anti-body, sequential electro-diagnostic tests and availability of physiotherapy to have better model that predict outcome of GBS.},
 year = {2022}
}

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TY  - JOUR
T1  - Assessing the Predictors and Outcomes of Guillain-Barré Syndrome at St. Paul’s and Zewditu Hospitals in Addis Ababa, Ethiopia
AU  - Wubakal Teshome
AU  - Tesfaye Dagne
AU  - Tsegaye Getachew
Y1  - 2022/09/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ajnhs.20220303.15
DO  - 10.11648/j.ajnhs.20220303.15
T2  - American Journal of Nursing and Health Sciences
JF  - American Journal of Nursing and Health Sciences
JO  - American Journal of Nursing and Health Sciences
SP  - 73
EP  - 83
PB  - Science Publishing Group
SN  - 2994-7227
UR  - https://doi.org/10.11648/j.ajnhs.20220303.15
AB  - Guillain–Barré Syndrome (GBS) is the most frequent cause of acute flaccid paralysis worldwide and constitute one of serious emergencies in neurology. In Ethiopia there is high prevalence of infectious disease influencing the prevalence as well as the subsequent outcome of GBS where there is significant constrain in the availability of critical care, rehabilitation and social service. So, the objective of this study is assessing predictors and outcomes of Guillain-Barré Syndrome. Retrospective cross sectional study was used and all patients who fulfill the inclusion criteria’s for GBS in the 7 years period were included. The organized data was interpreted using descriptive methods in the form of tables, charts, and graphs in the SPSS version 20 and Excel software. Binary logistic regression analysis was used to assess the association between exposure variables and outcome of GBS. And univariate analysis performed to screen out potentially significant independent variables to be included in the multivariable binary logistic regression. The most common presenting symptoms were muscle weakness (91), respiratory muscle involvement (32) and Cranial Nerve involvement (27). HIV (40.64%) and DM (31.25%) were important comorbid illness. Cranial nerve palsies, respiratory compromise, disability score, need of mechanical ventilation, HIV and DM were significantly associated with worse outcome. Common GBS variants identified were AMAN (36%) and AIDP (30%), AMAN type were associated with unfortunate outcome. GBS-specific therapy was administered in 43.96% patients and having appropriate treatment had lower incidence of poor outcome. Generally, this study showed 60% of patients had good outcome (GDS ≤ 2) and 40% of bad outcome (GDS > 2). Digitization of medical recording evaluation report using a software based template would help to improve the completeness of each patient report and awareness of predictors of GBS outcome and being perceptive for alarming features will help allocate resource in keen manner in our resource restricted setting. Having GBS specific treatments available in affordable and accessible manner will inflict significant light in the prognosis of GBS patients. It would be better to conduct further studies on Concordance between molecular tests, anti-body, sequential electro-diagnostic tests and availability of physiotherapy to have better model that predict outcome of GBS.
VL  - 3
IS  - 3
ER  - 

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