Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation

Xiuling Chen; Yu Ding; Fuxiang Luo; Chunli Wang

doi:doi:10.11648/j.ajns.20200904.32

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Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation

Xiuling Chen, Yu Ding, Fuxiang Luo, Chunli Wang

Published in American Journal of Nursing Science (Volume 9, Issue 4)

Received: 16 July 2020 Accepted: 28 July 2020 Published: 30 July 2020

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Abstract

Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X²=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.

Published in	American Journal of Nursing Science (Volume 9, Issue 4)
DOI	10.11648/j.ajns.20200904.32
Page(s)	290-294
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Recombinant Human Interleukin-11, Oral Mucositis, Malignant Hematologic

References

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[2]	Al-Ansari S, Zecha JA, Barasch A, de Lange J, Rozema FR, Raber-Durlacher JE: Oral Mucositis Induced By Anticancer Therapies. Current oral health reports 2015, 2 (4): 202-211.
[3]	Curra M, Soares Junior LAV, Martins MD, Santos P: Chemotherapy protocols and incidence of oral mucositis. An integrative review. Einstein (Sao Paulo, Brazil) 2018, 16 (1): eRW4007.
[4]	Traber KE, Dimbo EL, Symer EM, Korkmaz FT, Jones MR, Mizgerd JP, Quinton LJ: Roles of interleukin-11 during acute bacterial pneumonia. PloS one 2019, 14 (8): e0221029.
[5]	Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS et al: Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology 2019, 157 (3): 777-792. e714.
[6]	Pan Y, Wu H, Li Y: [Effect of recombinant human interleukin-11 treatment on prognosis of patients with radiochemoradiotherapy in the treatment of nasopharyngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 2017, 31 (12): 945-948.
[7]	Pereira NF, Silva P, Fukuoka CY, Michel-Crosato E, Gonçalves AS, Alves FA, Vieira GMM, Biazevic MGH: Measurement of oral health quality of life among patients who underwent haematopoietic stem-cell transplantation. Brazilian oral research 2018, 32: e78.
[8]	Xu L, Chen H, Chen J, Han M, Huang H, Lai Y, Liu D, Liu Q, Liu T, Jiang M et al: The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China-recommendations from the Chinese Society of Hematology. Journal of hematology & oncology 2018, 11 (1): 33.
[9]	Van der Beek JN, Oosterom N, Pieters R, de Jonge R, van den Heuvel-Eibrink MM, Heil SG: The effect of leucovorin rescue therapy on methotrexate-induced oral mucositis in the treatment of paediatric ALL: A systematic review. Critical reviews in oncology/hematology 2019, 142: 1-8.
[10]	Piccin A, Tagnin M, Vecchiato C, Al-Khaffaf A, Beqiri L, Kaiser C, Agreiter I, Negri G, Kob M, Di Pierro A et al: Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: a large retrospective study. International journal of hematology 2018, 108 (6): 615-621.
[11]	Liu NW, Huang X, Liu S, Liu WJ, Wang H, Wang WD, Lu Y: Elevated BNP caused by recombinant human interleukin-11 treatment in patients with chemotherapy-induced thrombocytopenia. Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer 2019, 27 (11): 4293-4298.
[12]	Abu El-Asrar AM, Ahmad A, Allegaert E, Siddiquei MM, Gikandi PW, De Hertogh G, Opdenakker G: Interleukin-11 Overexpression and M2 Macrophage Density are Associated with Angiogenic Activity in Proliferative Diabetic Retinopathy. Ocular immunology and inflammation 2020, 28 (4): 575-588.
[13]	Mallick S, Benson R, Rath GK: Radiation induced oral mucositis: a review of current literature on prevention and management. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2016, 273 (9): 2285-2293.

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APA Style

Xiuling Chen, Yu Ding, Fuxiang Luo, Chunli Wang. (2020). Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. American Journal of Nursing Science, 9(4), 290-294. https://doi.org/10.11648/j.ajns.20200904.32

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ACS Style

Xiuling Chen; Yu Ding; Fuxiang Luo; Chunli Wang. Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. Am. J. Nurs. Sci. 2020, 9(4), 290-294. doi: 10.11648/j.ajns.20200904.32

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AMA Style

Xiuling Chen, Yu Ding, Fuxiang Luo, Chunli Wang. Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. Am J Nurs Sci. 2020;9(4):290-294. doi: 10.11648/j.ajns.20200904.32

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@article{10.11648/j.ajns.20200904.32,
  author = {Xiuling Chen and Yu Ding and Fuxiang Luo and Chunli Wang},
  title = {Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation},
  journal = {American Journal of Nursing Science},
  volume = {9},
  number = {4},
  pages = {290-294},
  doi = {10.11648/j.ajns.20200904.32},
  url = {https://doi.org/10.11648/j.ajns.20200904.32},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20200904.32},
  abstract = {Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X2=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.},
 year = {2020}
}

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TY  - JOUR
T1  - Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation
AU  - Xiuling Chen
AU  - Yu Ding
AU  - Fuxiang Luo
AU  - Chunli Wang
Y1  - 2020/07/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ajns.20200904.32
DO  - 10.11648/j.ajns.20200904.32
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 290
EP  - 294
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20200904.32
AB  - Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X2=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.
VL  - 9
IS  - 4
ER  -

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Author Information

Xiuling Chen

Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Yu Ding

Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Fuxiang Luo

Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China
Chunli Wang

Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China

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APA Style

Xiuling Chen, Yu Ding, Fuxiang Luo, Chunli Wang. (2020). Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. American Journal of Nursing Science, 9(4), 290-294. https://doi.org/10.11648/j.ajns.20200904.32

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ACS Style

Xiuling Chen; Yu Ding; Fuxiang Luo; Chunli Wang. Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. Am. J. Nurs. Sci. 2020, 9(4), 290-294. doi: 10.11648/j.ajns.20200904.32

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AMA Style

Xiuling Chen, Yu Ding, Fuxiang Luo, Chunli Wang. Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation. Am J Nurs Sci. 2020;9(4):290-294. doi: 10.11648/j.ajns.20200904.32

Copy | Download

@article{10.11648/j.ajns.20200904.32,
  author = {Xiuling Chen and Yu Ding and Fuxiang Luo and Chunli Wang},
  title = {Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation},
  journal = {American Journal of Nursing Science},
  volume = {9},
  number = {4},
  pages = {290-294},
  doi = {10.11648/j.ajns.20200904.32},
  url = {https://doi.org/10.11648/j.ajns.20200904.32},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20200904.32},
  abstract = {Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X2=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation
AU  - Xiuling Chen
AU  - Yu Ding
AU  - Fuxiang Luo
AU  - Chunli Wang
Y1  - 2020/07/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ajns.20200904.32
DO  - 10.11648/j.ajns.20200904.32
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 290
EP  - 294
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20200904.32
AB  - Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X2=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.
VL  - 9
IS  - 4
ER  -

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