Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter

Ying Wu; Guohua Huang; Jinai He; Yutong Li

doi:doi:10.11648/j.ajns.20231202.14

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Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter

Ying Wu, Guohua Huang, Jinai He, Yutong Li

Published in American Journal of Nursing Science (Volume 12, Issue 2)

Received: 8 April 2023 Accepted: 26 April 2023 Published: 10 May 2023

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Abstract

Objective: This study investigated the effect of heparinized saline flushed catheter on preventing catheter-related thrombosis (CRT) among cancer patients received peripherally inserted central catheter (PICC) for chemotherapy. Background: CRT is a common and serious complication when using PICC, which is one of the most commonly used vascular access devices for drug infusion, intravenous nutrition, and chemotherapy. Methods: This prospective, paralled-group trial enrolled 300 cancer patients received chemotherapy who were randomly assigned to the intervention (n=150) or control (n=150) group. Besides the basic procedure of PICC combined with IC- ECG and B-mode ultrasound imaging, heparinized saline flushed catheters were used in the intervention group, while normal saline flushed ones were used in the control group. Hemorheology tests and tip sites measurements were used in outcome evaluation, and the incidences of CRT and other complications. In additions, thromboelastogram (TEG) were used to measure thrombus elastic before and one week after PICC. Results: 148 patients in the intervention group and 138 patients in the control group finished PICC and follow-ups, which indicating longer duration and more completion of PICC with better catheter tip positioning in the intervention group. Intervention subjects showed significant lower incidences of CRT and other complications (phlebitis, catheter blockage, catheter prolapse, and local infection) (P <.05). In additons, our proposed method may reduce CRT incidence via significantly improving blood circulation among patients received chemotherapy via PICC. Conclusion: Heparinized saline flushed catheter may increase chemotherapy completion quality via PICC, reduce the risk of catheter-related thrombosis complications, and reduce CRT incidence via improving blood circulation. Conclusions: This proposed method can be easily introduced to prolong the duration of the placement and improve the blood circulation of cancer patients received PICC.

Published in	American Journal of Nursing Science (Volume 12, Issue 2)
DOI	10.11648/j.ajns.20231202.14
Page(s)	44-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Heparinized, Saline, Flushing, Intracavitary, Electrocardiography, Catheter- Related Thrombosis

References

[1]	Mielke D, Wittig A, Teichgräber U. (2020). Peripherally inserted central venous catheter (PICC) in outpatient and inpatient oncological treatment [J]. Support Care Cancer, 28 (10): 4753-4760.
[2]	Taxbro K, Hammarskjöld F, Thelin B, et al. (2019). Clinical impact of peripherally inserted central catheters vs implanted port catheters in patients with cancer: an open-label, randomised, two-centre trial [J]. Br JAnaesth, 122 (6): 734-741.
[3]	Wang K, Zhong J, Huang N, et al. (2020). Economic evaluation of peripherally inserted central catheter and other venous access devices: A scoping review [J]. J Vasc Access, 21 (6): 826-837.
[4]	Dupont C, Gouya H, Panzo R, et al. (2015). Complications of peripherally inserted central in adults with cystic fibrosis or bronchiectasis [J]. J Vasc Acce, 16 (3): 245.
[5]	Bertoglio S, Faccini B, Lalli L, et al. (2016). Peripherally inserted central catheters (PICCs) in cancer patients under chemotherapy: a prospective study on the incidence of complications and overall failures [J]. J Surg Onco, 113 (6): 708-714.
[6]	Huo Yuqing, Guo Ying, Qin Fang, et al. (2018). Influence of the improved PICC related venous thrombosis risk assessment table on the risk prediction efficiency of tumor patients [J]. Journal of Qilu Nursing, 24 (7): 43-45.
[7]	Luo L, Jing XM, Wang GR, et al. (2016). Peripherally inserted central catheter-related upper extremity venous thrombosis in oncology patients: a prospective study based on Doppler Sonongraphy [J]. J Ultrasound Med, 35 (8): 1759- 1763.
[8]	Zhang Ying, Li Aimin, Guan Chenyang, et al. (2019). Evaluation of the effect of different activities on prevention of PICC catheter-related thrombosis [J]. Chinese Journal of nursing, 54 (9): 1390- 1393.
[9]	Itkin M, Mondshein JI, Stavropoulos, SW, et al. (2014). Peripherally inserted central catheter thrombosis—reverse tapered versus nontapered catheters: a randomized controlled study [J]. J vasc Interv Radiol, 25 (1): 85-91.
[10]	Hinck SM. (2021). Implementing the infusion therapy standards of practice [J]. Home Healthc Now, 39 (5): 295.
[11]	Fallouh N, McGuirk HM, Flanders SA, et al. (2015). Peripherally inserted central catheter-associated deep vein thrombosis: a narrative review [J]. Am J Med, 128 (7): 722-38.
[12]	Zhou Donglian, Liu Qingxia, Zeng Xiaoyan. (2017). Nursing observation of low molecular weight heparin sodium synchronous whole course anticoagulation on patients with lung cancer after PICC catheterization [J]. China modern doctor, 55 (24): 144- 147.
[13]	Lv S, Liu Y, Wei G, et al. (2019). The anticoagulants rivaroxaban and low molecular weight heparin prevent PICC-related upper extremity venous thrombosis in cancer patients [J]. Medicine, 98 (47): e17894.
[14]	Bradford NK, Edwards RM, Chan RJ. (2020). Normal saline (0.9% sodium chloride) versus heparin intermittent flushing for the prevention of occlusion in long-term central venous catheters in infants and children [J]. Cochrane Database Syst Rev, 4 (4): CD010996.
[15]	Deng Fengliang, Xie Jianhui, Li Zhiguo, et al. (2019). Research progress of catheter tip positioning method in children's PICC catheterization [J]. Journal of nurses training, 34 (16): 1488- 1490.
[16]	Yu C, Shulan L, Juan W, et al. (2022). The accuracy and safety of using the electrocardiogram positioning technique in localizing the peripherally inserted central catheter tip position: A systematic review and meta-analysis [J]. Nurs Open, 9 (3): 1556- 1563.
[17]	Kleidon TM, Horowitz J, Rickard CM, et al. (2021). Peripherally Inserted Central Catheter Thrombosis After Placement via Electrocardiography vs Traditional Methods [J]. Am J Med, 134 (2): e79-e88.
[18]	Yin YX, Gao W, Li XY, et al. (2020). Randomized multicenter study on long-term complications of peripherally inserted central catheters positioned by electrocardiographic technique [J]. Phlebology, 35 (8): 614-622.
[19]	Xu Bo, Geng Cuizhi, Lu Zhenqi, et al. (2015). Safety guidelines for vascular access in tumor treatment. Beijing: China Union Medical College Press.
[20]	Tang Hongmei, Tang Yonghong, Liu Suxia, et al. (2015). A study on the correlation between the position of the central venous catheter tip and the use time in neonates [J]. Laboratory medicine and clinic, 12 (18): 2759-2760.
[21]	Chen L, Yu C, Li J. (2015). Retrospective analysis of peripherally inserted central catheter-related vein thrombosis in lung cancer patients [J]. Chinese journal of lung cancer, 18 (9): 549-53.
[22]	Xue Yujia, Li Zijian. (2022, May 27). Research progress in thromboelastography, thrombin formation test and thrombokinetic analysis. International Journal of laboratory medicine: 1-4. Retrieved from http://kns.cnki.net/kcms/detail/50.1176.R.20220506.1134.002.html
[23]	Su Hongmei, Ren Yong, Wu Hongfang, et al. (2022). Application effect of thromboelastography and routine coagulation test in chronic kidney disease [J]. China health standard management, 13 (08): 866-869.
[24]	Du Hongdao, Dong Yanming, Bao Guoqiang. (2020). The role of thromboelastography in the prevention of PICC related venous thrombosis in tumor patients [J]. Chinese Journal of Thrombosis and Hemostasis, 26 (04): 602-603.
[25]	Liao Xiangcheng, Sun Ke, Mo Zhuning, et al. (2021). Study on the correlation between perioperative thromboelastogram parameters and coagulation function, inflammation and hemorheology in patients with traumatic closed fracture of lower limbs [J]. Chinese Journal ofNew Clinical Medicine, 14 (12): 1225-1228.
[26]	Vaya, A, Suescun M. (2013). Hemorheological parameters as independent predictors of venous thromboembolism [J]. Clin Hemorherol Microcirc, 53 (1-2): 131-41.

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APA Style

Ying Wu, Guohua Huang, Jinai He, Yutong Li. (2023). Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. American Journal of Nursing Science, 12(2), 44-49. https://doi.org/10.11648/j.ajns.20231202.14

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ACS Style

Ying Wu; Guohua Huang; Jinai He; Yutong Li. Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. Am. J. Nurs. Sci. 2023, 12(2), 44-49. doi: 10.11648/j.ajns.20231202.14

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AMA Style

Ying Wu, Guohua Huang, Jinai He, Yutong Li. Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. Am J Nurs Sci. 2023;12(2):44-49. doi: 10.11648/j.ajns.20231202.14

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@article{10.11648/j.ajns.20231202.14,
  author = {Ying Wu and Guohua Huang and Jinai He and Yutong Li},
  title = {Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter},
  journal = {American Journal of Nursing Science},
  volume = {12},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajns.20231202.14},
  url = {https://doi.org/10.11648/j.ajns.20231202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20231202.14},
  abstract = {Objective: This study investigated the effect of heparinized saline flushed catheter on preventing catheter-related thrombosis (CRT) among cancer patients received peripherally inserted central catheter (PICC) for chemotherapy. Background: CRT is a common and serious complication when using PICC, which is one of the most commonly used vascular access devices for drug infusion, intravenous nutrition, and chemotherapy. Methods: This prospective, paralled-group trial enrolled 300 cancer patients received chemotherapy who were randomly assigned to the intervention (n=150) or control (n=150) group. Besides the basic procedure of PICC combined with IC- ECG and B-mode ultrasound imaging, heparinized saline flushed catheters were used in the intervention group, while normal saline flushed ones were used in the control group. Hemorheology tests and tip sites measurements were used in outcome evaluation, and the incidences of CRT and other complications. In additions, thromboelastogram (TEG) were used to measure thrombus elastic before and one week after PICC. Results: 148 patients in the intervention group and 138 patients in the control group finished PICC and follow-ups, which indicating longer duration and more completion of PICC with better catheter tip positioning in the intervention group. Intervention subjects showed significant lower incidences of CRT and other complications (phlebitis, catheter blockage, catheter prolapse, and local infection) (P <.05). In additons, our proposed method may reduce CRT incidence via significantly improving blood circulation among patients received chemotherapy via PICC. Conclusion: Heparinized saline flushed catheter may increase chemotherapy completion quality via PICC, reduce the risk of catheter-related thrombosis complications, and reduce CRT incidence via improving blood circulation. Conclusions: This proposed method can be easily introduced to prolong the duration of the placement and improve the blood circulation of cancer patients received PICC.},
 year = {2023}
}

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TY  - JOUR
T1  - Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter
AU  - Ying Wu
AU  - Guohua Huang
AU  - Jinai He
AU  - Yutong Li
Y1  - 2023/05/10
PY  - 2023
N1  - https://doi.org/10.11648/j.ajns.20231202.14
DO  - 10.11648/j.ajns.20231202.14
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20231202.14
AB  - Objective: This study investigated the effect of heparinized saline flushed catheter on preventing catheter-related thrombosis (CRT) among cancer patients received peripherally inserted central catheter (PICC) for chemotherapy. Background: CRT is a common and serious complication when using PICC, which is one of the most commonly used vascular access devices for drug infusion, intravenous nutrition, and chemotherapy. Methods: This prospective, paralled-group trial enrolled 300 cancer patients received chemotherapy who were randomly assigned to the intervention (n=150) or control (n=150) group. Besides the basic procedure of PICC combined with IC- ECG and B-mode ultrasound imaging, heparinized saline flushed catheters were used in the intervention group, while normal saline flushed ones were used in the control group. Hemorheology tests and tip sites measurements were used in outcome evaluation, and the incidences of CRT and other complications. In additions, thromboelastogram (TEG) were used to measure thrombus elastic before and one week after PICC. Results: 148 patients in the intervention group and 138 patients in the control group finished PICC and follow-ups, which indicating longer duration and more completion of PICC with better catheter tip positioning in the intervention group. Intervention subjects showed significant lower incidences of CRT and other complications (phlebitis, catheter blockage, catheter prolapse, and local infection) (P <.05). In additons, our proposed method may reduce CRT incidence via significantly improving blood circulation among patients received chemotherapy via PICC. Conclusion: Heparinized saline flushed catheter may increase chemotherapy completion quality via PICC, reduce the risk of catheter-related thrombosis complications, and reduce CRT incidence via improving blood circulation. Conclusions: This proposed method can be easily introduced to prolong the duration of the placement and improve the blood circulation of cancer patients received PICC.
VL  - 12
IS  - 2
ER  -

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Author Information

Ying Wu

Department of Venous Catheterization, The First Affiliated Hospital of Jinan University, Guangzhou, China
Guohua Huang

Department of Venous Catheterization, The First Affiliated Hospital of Jinan University, Guangzhou, China
Jinai He

Department of Venous Catheterization, The First Affiliated Hospital of Jinan University, Guangzhou, China
Yutong Li

Department of Venous Catheterization, The First Affiliated Hospital of Jinan University, Guangzhou, China

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Ying Wu, Guohua Huang, Jinai He, Yutong Li. (2023). Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. American Journal of Nursing Science, 12(2), 44-49. https://doi.org/10.11648/j.ajns.20231202.14

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ACS Style

Ying Wu; Guohua Huang; Jinai He; Yutong Li. Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. Am. J. Nurs. Sci. 2023, 12(2), 44-49. doi: 10.11648/j.ajns.20231202.14

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AMA Style

Ying Wu, Guohua Huang, Jinai He, Yutong Li. Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter. Am J Nurs Sci. 2023;12(2):44-49. doi: 10.11648/j.ajns.20231202.14

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@article{10.11648/j.ajns.20231202.14,
  author = {Ying Wu and Guohua Huang and Jinai He and Yutong Li},
  title = {Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter},
  journal = {American Journal of Nursing Science},
  volume = {12},
  number = {2},
  pages = {44-49},
  doi = {10.11648/j.ajns.20231202.14},
  url = {https://doi.org/10.11648/j.ajns.20231202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20231202.14},
  abstract = {Objective: This study investigated the effect of heparinized saline flushed catheter on preventing catheter-related thrombosis (CRT) among cancer patients received peripherally inserted central catheter (PICC) for chemotherapy. Background: CRT is a common and serious complication when using PICC, which is one of the most commonly used vascular access devices for drug infusion, intravenous nutrition, and chemotherapy. Methods: This prospective, paralled-group trial enrolled 300 cancer patients received chemotherapy who were randomly assigned to the intervention (n=150) or control (n=150) group. Besides the basic procedure of PICC combined with IC- ECG and B-mode ultrasound imaging, heparinized saline flushed catheters were used in the intervention group, while normal saline flushed ones were used in the control group. Hemorheology tests and tip sites measurements were used in outcome evaluation, and the incidences of CRT and other complications. In additions, thromboelastogram (TEG) were used to measure thrombus elastic before and one week after PICC. Results: 148 patients in the intervention group and 138 patients in the control group finished PICC and follow-ups, which indicating longer duration and more completion of PICC with better catheter tip positioning in the intervention group. Intervention subjects showed significant lower incidences of CRT and other complications (phlebitis, catheter blockage, catheter prolapse, and local infection) (P <.05). In additons, our proposed method may reduce CRT incidence via significantly improving blood circulation among patients received chemotherapy via PICC. Conclusion: Heparinized saline flushed catheter may increase chemotherapy completion quality via PICC, reduce the risk of catheter-related thrombosis complications, and reduce CRT incidence via improving blood circulation. Conclusions: This proposed method can be easily introduced to prolong the duration of the placement and improve the blood circulation of cancer patients received PICC.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Heparinized Saline Flushed Catheter May Reduce Risk of Thrombosis in Cancer Patients Received Chemotherapy with Peripherally Inserted Central Catheter
AU  - Ying Wu
AU  - Guohua Huang
AU  - Jinai He
AU  - Yutong Li
Y1  - 2023/05/10
PY  - 2023
N1  - https://doi.org/10.11648/j.ajns.20231202.14
DO  - 10.11648/j.ajns.20231202.14
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 44
EP  - 49
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20231202.14
AB  - Objective: This study investigated the effect of heparinized saline flushed catheter on preventing catheter-related thrombosis (CRT) among cancer patients received peripherally inserted central catheter (PICC) for chemotherapy. Background: CRT is a common and serious complication when using PICC, which is one of the most commonly used vascular access devices for drug infusion, intravenous nutrition, and chemotherapy. Methods: This prospective, paralled-group trial enrolled 300 cancer patients received chemotherapy who were randomly assigned to the intervention (n=150) or control (n=150) group. Besides the basic procedure of PICC combined with IC- ECG and B-mode ultrasound imaging, heparinized saline flushed catheters were used in the intervention group, while normal saline flushed ones were used in the control group. Hemorheology tests and tip sites measurements were used in outcome evaluation, and the incidences of CRT and other complications. In additions, thromboelastogram (TEG) were used to measure thrombus elastic before and one week after PICC. Results: 148 patients in the intervention group and 138 patients in the control group finished PICC and follow-ups, which indicating longer duration and more completion of PICC with better catheter tip positioning in the intervention group. Intervention subjects showed significant lower incidences of CRT and other complications (phlebitis, catheter blockage, catheter prolapse, and local infection) (P <.05). In additons, our proposed method may reduce CRT incidence via significantly improving blood circulation among patients received chemotherapy via PICC. Conclusion: Heparinized saline flushed catheter may increase chemotherapy completion quality via PICC, reduce the risk of catheter-related thrombosis complications, and reduce CRT incidence via improving blood circulation. Conclusions: This proposed method can be easily introduced to prolong the duration of the placement and improve the blood circulation of cancer patients received PICC.
VL  - 12
IS  - 2
ER  -

Copy | Download