Hypoglycaemia in the Early Neonatal Period in Newborns

Tatyana E. Taranushenko; Ekaterina V. Antsiferova; Natalia G. Kiseleva

doi:doi:10.11648/j.ajp.20220801.15

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Hypoglycaemia in the Early Neonatal Period in Newborns

Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva

Published in American Journal of Pediatrics (Volume 8, Issue 1)

Received: 23 January 2021 Accepted: 22 April 2021 Published: 28 January 2022

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Abstract

Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).

Published in	American Journal of Pediatrics (Volume 8, Issue 1)
DOI	10.11648/j.ajp.20220801.15
Page(s)	17-22
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Newborns, Diabetic Fetopathy, Hypoglycemia in Newborns, Intrauterine Growth Restriction, High Birth Weight

References

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[2]	Qiao L. X., Wang J., Yan J. H., Xu S. X., Wang H., Zhu W. Y., Zhang H. Y., Li J., Feng X. Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia. BMC Pediatr. 2019; 19 (1): 133. doi: 10.1186/s12887-019-1509-4.
[3]	Chappe M. K. Hypoglycemia in High-Risk Infants Within the Immediate Postnatal Period. Neonatal Netw. 2020; 39 (5): 263-267. doi: 10.1891/0730-0832.39.5.263.
[4]	Edwards T., Harding J. E. Clinical Aspects of Neonatal Hypoglycemia: A Mini Review. Front Pediatr. 2021; 8: 562251. doi: 10.3389/fped.2020.562251.
[5]	Gu M. H., Amanda F., Yuan T. M. Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study. Clin Med Insights Pediatr. 2019; 13: 1179556519867953. doi: 10.1177/1179556519867953.
[6]	Volodin N. N. Neonatology: a national guide. Short edition. M.: GEOTAR-Media, 2019; 896 (in Russ).
[7]	Casertano A., Rossi A., Fecarotta S., Rosanio F. M., Moracas C., Di Candia F., Parenti G., Franzese A., Mozzillo E. An Overview of Hypoglycemia in Children Including a Comprehensive Practical Diagnostic Flowchart for Clinical Use. Front Endocrinol (Lausanne). 2021; 12: 684011. doi: 10.3389/fendo.2021.684011.
[8]	Finken M. J. J., van der Steen M., Smeets C. C. J., Walenkamp M. J. E., de Bruin C., Hokken-Koelega A. C. S., Wit J. M. Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications. Endocr Rev. 2018; 39 (6): 851-894. doi: 10.1210/er.2018-00083. Erratum in: Endocr Rev. 2019; 40 (1): 96.
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[11]	Gou B. H., Guan H. M., Bi Y. X., Ding B. J. Gestational diabetes: weight gain during pregnancy and its relationship to pregnancy outcomes. Chin Med J (Engl). 2019; 132 (2): 154-160. doi: 10.1097/CM9.0000000000000036.
[12]	Abramowski A., Ward R., Hamdan A. H. Neonatal Hypoglycemia. 2021 Sep 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30725790.
[13]	Ornoy A., Becker M., Weinstein-Fudim L., Ergaz Z. Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review. Int J Mol Sci. 2021; 22 (6): 2965. doi: 10.3390/ijms22062965.
[14]	De Angelis L. C., Brigati G., Polleri G., Malova M., Parodi A., Minghetti D., Rossi A., Massirio P., Traggiai C., Maghnie M., Ramenghi L. A. Neonatal Hypoglycemia and Brain Vulnerability. Front Endocrinol (Lausanne). 2021; 12: 634305. doi: 10.3389/fendo.2021.634305.
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APA Style

Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. (2022). Hypoglycaemia in the Early Neonatal Period in Newborns. American Journal of Pediatrics, 8(1), 17-22. https://doi.org/10.11648/j.ajp.20220801.15

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ACS Style

Tatyana E. Taranushenko; Ekaterina V. Antsiferova; Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am. J. Pediatr. 2022, 8(1), 17-22. doi: 10.11648/j.ajp.20220801.15

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AMA Style

Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am J Pediatr. 2022;8(1):17-22. doi: 10.11648/j.ajp.20220801.15

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@article{10.11648/j.ajp.20220801.15,
  author = {Tatyana E. Taranushenko and Ekaterina V. Antsiferova and Natalia G. Kiseleva},
  title = {Hypoglycaemia in the Early Neonatal Period in Newborns},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {1},
  pages = {17-22},
  doi = {10.11648/j.ajp.20220801.15},
  url = {https://doi.org/10.11648/j.ajp.20220801.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220801.15},
  abstract = {Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).},
 year = {2022}
}

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TY  - JOUR
T1  - Hypoglycaemia in the Early Neonatal Period in Newborns
AU  - Tatyana E. Taranushenko
AU  - Ekaterina V. Antsiferova
AU  - Natalia G. Kiseleva
Y1  - 2022/01/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220801.15
DO  - 10.11648/j.ajp.20220801.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 17
EP  - 22
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220801.15
AB  - Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).
VL  - 8
IS  - 1
ER  -

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Author Information

Tatyana E. Taranushenko

Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia
Ekaterina V. Antsiferova

Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia
Natalia G. Kiseleva

Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia

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APA Style

Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. (2022). Hypoglycaemia in the Early Neonatal Period in Newborns. American Journal of Pediatrics, 8(1), 17-22. https://doi.org/10.11648/j.ajp.20220801.15

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ACS Style

Tatyana E. Taranushenko; Ekaterina V. Antsiferova; Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am. J. Pediatr. 2022, 8(1), 17-22. doi: 10.11648/j.ajp.20220801.15

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AMA Style

Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am J Pediatr. 2022;8(1):17-22. doi: 10.11648/j.ajp.20220801.15

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@article{10.11648/j.ajp.20220801.15,
  author = {Tatyana E. Taranushenko and Ekaterina V. Antsiferova and Natalia G. Kiseleva},
  title = {Hypoglycaemia in the Early Neonatal Period in Newborns},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {1},
  pages = {17-22},
  doi = {10.11648/j.ajp.20220801.15},
  url = {https://doi.org/10.11648/j.ajp.20220801.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220801.15},
  abstract = {Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).},
 year = {2022}
}

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TY  - JOUR
T1  - Hypoglycaemia in the Early Neonatal Period in Newborns
AU  - Tatyana E. Taranushenko
AU  - Ekaterina V. Antsiferova
AU  - Natalia G. Kiseleva
Y1  - 2022/01/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220801.15
DO  - 10.11648/j.ajp.20220801.15
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 17
EP  - 22
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220801.15
AB  - Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).
VL  - 8
IS  - 1
ER  -

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