Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria.
| Published in | American Journal of Pediatrics (Volume 8, Issue 2) |
| DOI | 10.11648/j.ajp.20220802.27 |
| Page(s) | 146-151 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Bacterial Meningitis, Children, Pathogens, Antibiotics
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APA Style
Dewi Sutriani Mahalini, Putu Pradnyanita Mustika, I Gusti Ngurah Made Suwarba. (2022). Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. American Journal of Pediatrics, 8(2), 146-151. https://doi.org/10.11648/j.ajp.20220802.27
ACS Style
Dewi Sutriani Mahalini; Putu Pradnyanita Mustika; I Gusti Ngurah Made Suwarba. Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. Am. J. Pediatr. 2022, 8(2), 146-151. doi: 10.11648/j.ajp.20220802.27
AMA Style
Dewi Sutriani Mahalini, Putu Pradnyanita Mustika, I Gusti Ngurah Made Suwarba. Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020. Am J Pediatr. 2022;8(2):146-151. doi: 10.11648/j.ajp.20220802.27
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Download@article{10.11648/j.ajp.20220802.27,
author = {Dewi Sutriani Mahalini and Putu Pradnyanita Mustika and I Gusti Ngurah Made Suwarba},
title = {Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020},
journal = {American Journal of Pediatrics},
volume = {8},
number = {2},
pages = {146-151},
doi = {10.11648/j.ajp.20220802.27},
url = {https://doi.org/10.11648/j.ajp.20220802.27},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220802.27},
abstract = {Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria.},
year = {2022}
}
TY - JOUR T1 - Microorganism and Antibiotik Sensitivity Pattern of Children Bacterial Meningitis in Denpasar Tertiary Hospital 2019-2020 AU - Dewi Sutriani Mahalini AU - Putu Pradnyanita Mustika AU - I Gusti Ngurah Made Suwarba Y1 - 2022/06/27 PY - 2022 N1 - https://doi.org/10.11648/j.ajp.20220802.27 DO - 10.11648/j.ajp.20220802.27 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 146 EP - 151 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20220802.27 AB - Introduction: Bacterial meningitis is a severe acute infection of the central nervous system that caused by bacteria. The antibiotic should be given immediately. An appropriate antibiotic may reduce the morbidity and mortality caused by bacterial meningitis. This study aims to evaluate the bacterial pattern and antibiotic sensitivity in children bacterial meningitis at tertiary hospital in Denpasar. Material and methods: This retrospective descriptive study was using a cross-sectional design that involved pediatric patients aged 1 month-18 years old with suspected bacterial meningitis who underwent a lumbar puncture at Sanglah Hospital from January 2019 to December 2020. The diagnosis of bacterial meningitis was made based on cerebrospinal fluid culture and antibiotic sensitivity test. Samples were taken by consecutive sampling method and would be excluded if the medical record was incomplete. Results: There were ninety five pediatric patients treated with suspected meningitis. Thirty-three subjects had positive cerebrospinal fluid culture results with eight of them were contaminants. The proportion of bacterial meningitis was 26.3%. Bacterial meningitis was more common in children younger less than two years old (72%) compare with older children. The most gram-positive bacteria were Staphylococcus sp. while for gram-negative was Acinetobacter sp. and Sphingomonas paucimobilis. Vancomycin had a high sensitivity (92.8%) for gram-positive therapy, while for gram-negative it was cephalosporin drug which is ceftriaxone and cefepime (63.6%). Conclusion: Ceftriaxone as the main choice of empiric therapy still has high sensitivity to gram-negative bacteria but low sensitivity to gram-positive bacteria. VL - 8 IS - 2 ER -
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