Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang; Jingyuan Fan; Lizhi Ouyang; Hua-Jun Shawn Fan

doi:doi:10.11648/j.ajset.20230801.14

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Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, Jingyuan Fan, Lizhi Ouyang, Hua-Jun Shawn Fan

Published in American Journal of Science, Engineering and Technology (Volume 8, Issue 1)

Received: 14 November 2022 Accepted: 12 December 2022 Published: 16 February 2023

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Abstract

Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.

Published in	American Journal of Science, Engineering and Technology (Volume 8, Issue 1)
DOI	10.11648/j.ajset.20230801.14
Page(s)	33-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

3D Printing Pesticide, Controlled-Release, Fused Deposition Modeling, Poly ε-caprolactone, Hydroxypropyl Methylcellulose

References

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APA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. (2023). Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. American Journal of Science, Engineering and Technology, 8(1), 33-41. https://doi.org/10.11648/j.ajset.20230801.14

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ACS Style

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am. J. Sci. Eng. Technol. 2023, 8(1), 33-41. doi: 10.11648/j.ajset.20230801.14

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AMA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am J Sci Eng Technol. 2023;8(1):33-41. doi: 10.11648/j.ajset.20230801.14

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@article{10.11648/j.ajset.20230801.14,
  author = {Ben Yao and Zhining Xu and Jianan Liu and Liang Yang and Jianping Shang and Jingyuan Fan and Lizhi Ouyang and Hua-Jun Shawn Fan},
  title = {Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide},
  journal = {American Journal of Science, Engineering and Technology},
  volume = {8},
  number = {1},
  pages = {33-41},
  doi = {10.11648/j.ajset.20230801.14},
  url = {https://doi.org/10.11648/j.ajset.20230801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajset.20230801.14},
  abstract = {Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.},
 year = {2023}
}

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TY - JOUR
T1 - Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide
AU - Ben Yao
AU - Zhining Xu
AU - Jianan Liu
AU - Liang Yang
AU - Jianping Shang
AU - Jingyuan Fan
AU - Lizhi Ouyang
AU - Hua-Jun Shawn Fan
Y1 - 2023/02/16
PY - 2023
N1 - https://doi.org/10.11648/j.ajset.20230801.14
DO - 10.11648/j.ajset.20230801.14
T2 - American Journal of Science, Engineering and Technology
JF - American Journal of Science, Engineering and Technology
JO - American Journal of Science, Engineering and Technology
SP - 33
EP - 41
PB - Science Publishing Group
SN - 2578-8353
UR - https://doi.org/10.11648/j.ajset.20230801.14
AB - Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.
VL - 8
IS - 1
ER -

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Author Information

Ben Yao

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Zhining Xu

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jianan Liu

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Liang Yang

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jianping Shang

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jingyuan Fan

Carnegie Vanguard High School, Houston, USA
Lizhi Ouyang

Department of Physics and Mathematics, Tennessee State University, Nashville, USA
Hua-Jun Shawn Fan

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China

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Plain Text BibTeX RIS

APA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. (2023). Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. American Journal of Science, Engineering and Technology, 8(1), 33-41. https://doi.org/10.11648/j.ajset.20230801.14

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ACS Style

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am. J. Sci. Eng. Technol. 2023, 8(1), 33-41. doi: 10.11648/j.ajset.20230801.14

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AMA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am J Sci Eng Technol. 2023;8(1):33-41. doi: 10.11648/j.ajset.20230801.14

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@article{10.11648/j.ajset.20230801.14,
  author = {Ben Yao and Zhining Xu and Jianan Liu and Liang Yang and Jianping Shang and Jingyuan Fan and Lizhi Ouyang and Hua-Jun Shawn Fan},
  title = {Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide},
  journal = {American Journal of Science, Engineering and Technology},
  volume = {8},
  number = {1},
  pages = {33-41},
  doi = {10.11648/j.ajset.20230801.14},
  url = {https://doi.org/10.11648/j.ajset.20230801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajset.20230801.14},
  abstract = {Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.},
 year = {2023}
}

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