Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use

Alphonse Rodrigue Djiboune; Nicolas Anton; Papa Mady Sy; Louis Augustin Diaga Diouf; Gora Mbaye; Sidy Mouhamed Dieng; Mamadou Soumboundou; Thierry Vandamme; Mounibe Diarra

doi:doi:10.11648/j.ejb.20210902.16

Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use

Alphonse Rodrigue Djiboune, Nicolas Anton, Papa Mady Sy, Louis Augustin Diaga Diouf, Gora Mbaye, Sidy Mouhamed Dieng, Mamadou Soumboundou, Thierry Vandamme, Mounibe Diarra

Published in European Journal of Biophysics (Volume 9, Issue 2)

Received: 29 November 2021 Accepted: 21 December 2021 Published: 29 December 2021

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Abstract

This present study is a continuation of our work entitled “pH-thermosensitive oral chitosan-based hydrogels containing phenobarbital for a potential pediatric use”. The results of that previous study have shown their potential use in newborns in particular premature newborns while the oral form containing phenobarbital is a tablet and is unsuitable for newborns. Thus, in order to have a suitable device for the administration of hydrogels oral formulations to newborns, we have done rheology studies to complement our work. For this we have studied the variation of the viscosity of hydrogels containing phenobarbital as a function of shear rate and time. Phenobarbital is an active drug used in neonatal treatment of epilepsy. The viscosity measurements of hydrogels are carried out using a Fungilab V'PAD Rotational Viscometer (100–240V/50–60Hz) Type 'R series then ANOVA test was used to analysis the results. The results showed that the hydrogels had a non-Newtonian behavior with shear-thinning and thixotropic type which depends on the chitosan concentration, the storage temperature hydrogels, the presence of Eudragit E100 and the final solution’s pH. Rheological properties study have shown that a syringe-type device would be suitable for oral administration of hydrogels formulations to neonates.

Published in	European Journal of Biophysics (Volume 9, Issue 2)
DOI	10.11648/j.ejb.20210902.16
Page(s)	92-99
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Rheological Properties Study, Oral Hydrogels, Phenobarbital, Pediatric

References

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APA Style

Alphonse Rodrigue Djiboune, Nicolas Anton, Papa Mady Sy, Louis Augustin Diaga Diouf, Gora Mbaye, et al. (2021). Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. European Journal of Biophysics, 9(2), 92-99. https://doi.org/10.11648/j.ejb.20210902.16

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ACS Style

Alphonse Rodrigue Djiboune; Nicolas Anton; Papa Mady Sy; Louis Augustin Diaga Diouf; Gora Mbaye, et al. Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. Eur. J. Biophys. 2021, 9(2), 92-99. doi: 10.11648/j.ejb.20210902.16

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AMA Style

Alphonse Rodrigue Djiboune, Nicolas Anton, Papa Mady Sy, Louis Augustin Diaga Diouf, Gora Mbaye, et al. Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. Eur J Biophys. 2021;9(2):92-99. doi: 10.11648/j.ejb.20210902.16

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@article{10.11648/j.ejb.20210902.16,
  author = {Alphonse Rodrigue Djiboune and Nicolas Anton and Papa Mady Sy and Louis Augustin Diaga Diouf and Gora Mbaye and Sidy Mouhamed Dieng and Mamadou Soumboundou and Thierry Vandamme and Mounibe Diarra},
  title = {Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use},
  journal = {European Journal of Biophysics},
  volume = {9},
  number = {2},
  pages = {92-99},
  doi = {10.11648/j.ejb.20210902.16},
  url = {https://doi.org/10.11648/j.ejb.20210902.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20210902.16},
  abstract = {This present study is a continuation of our work entitled “pH-thermosensitive oral chitosan-based hydrogels containing phenobarbital for a potential pediatric use”. The results of that previous study have shown their potential use in newborns in particular premature newborns while the oral form containing phenobarbital is a tablet and is unsuitable for newborns. Thus, in order to have a suitable device for the administration of hydrogels oral formulations to newborns, we have done rheology studies to complement our work. For this we have studied the variation of the viscosity of hydrogels containing phenobarbital as a function of shear rate and time. Phenobarbital is an active drug used in neonatal treatment of epilepsy. The viscosity measurements of hydrogels are carried out using a Fungilab V'PAD Rotational Viscometer (100–240V/50–60Hz) Type 'R series then ANOVA test was used to analysis the results. The results showed that the hydrogels had a non-Newtonian behavior with shear-thinning and thixotropic type which depends on the chitosan concentration, the storage temperature hydrogels, the presence of Eudragit E100 and the final solution’s pH. Rheological properties study have shown that a syringe-type device would be suitable for oral administration of hydrogels formulations to neonates.},
 year = {2021}
}

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TY  - JOUR
T1  - Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use
AU  - Alphonse Rodrigue Djiboune
AU  - Nicolas Anton
AU  - Papa Mady Sy
AU  - Louis Augustin Diaga Diouf
AU  - Gora Mbaye
AU  - Sidy Mouhamed Dieng
AU  - Mamadou Soumboundou
AU  - Thierry Vandamme
AU  - Mounibe Diarra
Y1  - 2021/12/29
PY  - 2021
N1  - https://doi.org/10.11648/j.ejb.20210902.16
DO  - 10.11648/j.ejb.20210902.16
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 92
EP  - 99
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20210902.16
AB  - This present study is a continuation of our work entitled “pH-thermosensitive oral chitosan-based hydrogels containing phenobarbital for a potential pediatric use”. The results of that previous study have shown their potential use in newborns in particular premature newborns while the oral form containing phenobarbital is a tablet and is unsuitable for newborns. Thus, in order to have a suitable device for the administration of hydrogels oral formulations to newborns, we have done rheology studies to complement our work. For this we have studied the variation of the viscosity of hydrogels containing phenobarbital as a function of shear rate and time. Phenobarbital is an active drug used in neonatal treatment of epilepsy. The viscosity measurements of hydrogels are carried out using a Fungilab V'PAD Rotational Viscometer (100–240V/50–60Hz) Type 'R series then ANOVA test was used to analysis the results. The results showed that the hydrogels had a non-Newtonian behavior with shear-thinning and thixotropic type which depends on the chitosan concentration, the storage temperature hydrogels, the presence of Eudragit E100 and the final solution’s pH. Rheological properties study have shown that a syringe-type device would be suitable for oral administration of hydrogels formulations to neonates.
VL  - 9
IS  - 2
ER  -

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Author Information

Alphonse Rodrigue Djiboune

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Nicolas Anton

National Center for Scientific Research, Bioactive Molecule Design and Application Laboratory, Joint Research Unit 7199, University of Strasbourg, Strasbourg, France
Papa Mady Sy

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Louis Augustin Diaga Diouf

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Gora Mbaye

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Sidy Mouhamed Dieng

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Mamadou Soumboundou

Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal
Thierry Vandamme

National Center for Scientific Research, Bioactive Molecule Design and Application Laboratory, Joint Research Unit 7199, University of Strasbourg, Strasbourg, France
Mounibe Diarra

Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal

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APA Style

Alphonse Rodrigue Djiboune, Nicolas Anton, Papa Mady Sy, Louis Augustin Diaga Diouf, Gora Mbaye, et al. (2021). Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. European Journal of Biophysics, 9(2), 92-99. https://doi.org/10.11648/j.ejb.20210902.16

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ACS Style

Alphonse Rodrigue Djiboune; Nicolas Anton; Papa Mady Sy; Louis Augustin Diaga Diouf; Gora Mbaye, et al. Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. Eur. J. Biophys. 2021, 9(2), 92-99. doi: 10.11648/j.ejb.20210902.16

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AMA Style

Alphonse Rodrigue Djiboune, Nicolas Anton, Papa Mady Sy, Louis Augustin Diaga Diouf, Gora Mbaye, et al. Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use. Eur J Biophys. 2021;9(2):92-99. doi: 10.11648/j.ejb.20210902.16

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@article{10.11648/j.ejb.20210902.16,
  author = {Alphonse Rodrigue Djiboune and Nicolas Anton and Papa Mady Sy and Louis Augustin Diaga Diouf and Gora Mbaye and Sidy Mouhamed Dieng and Mamadou Soumboundou and Thierry Vandamme and Mounibe Diarra},
  title = {Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use},
  journal = {European Journal of Biophysics},
  volume = {9},
  number = {2},
  pages = {92-99},
  doi = {10.11648/j.ejb.20210902.16},
  url = {https://doi.org/10.11648/j.ejb.20210902.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20210902.16},
  abstract = {This present study is a continuation of our work entitled “pH-thermosensitive oral chitosan-based hydrogels containing phenobarbital for a potential pediatric use”. The results of that previous study have shown their potential use in newborns in particular premature newborns while the oral form containing phenobarbital is a tablet and is unsuitable for newborns. Thus, in order to have a suitable device for the administration of hydrogels oral formulations to newborns, we have done rheology studies to complement our work. For this we have studied the variation of the viscosity of hydrogels containing phenobarbital as a function of shear rate and time. Phenobarbital is an active drug used in neonatal treatment of epilepsy. The viscosity measurements of hydrogels are carried out using a Fungilab V'PAD Rotational Viscometer (100–240V/50–60Hz) Type 'R series then ANOVA test was used to analysis the results. The results showed that the hydrogels had a non-Newtonian behavior with shear-thinning and thixotropic type which depends on the chitosan concentration, the storage temperature hydrogels, the presence of Eudragit E100 and the final solution’s pH. Rheological properties study have shown that a syringe-type device would be suitable for oral administration of hydrogels formulations to neonates.},
 year = {2021}
}

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TY  - JOUR
T1  - Rheological Properties Study of Oral Hydrogels Containing Phenobarbital for a Potiential Pediatric Use
AU  - Alphonse Rodrigue Djiboune
AU  - Nicolas Anton
AU  - Papa Mady Sy
AU  - Louis Augustin Diaga Diouf
AU  - Gora Mbaye
AU  - Sidy Mouhamed Dieng
AU  - Mamadou Soumboundou
AU  - Thierry Vandamme
AU  - Mounibe Diarra
Y1  - 2021/12/29
PY  - 2021
N1  - https://doi.org/10.11648/j.ejb.20210902.16
DO  - 10.11648/j.ejb.20210902.16
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 92
EP  - 99
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20210902.16
AB  - This present study is a continuation of our work entitled “pH-thermosensitive oral chitosan-based hydrogels containing phenobarbital for a potential pediatric use”. The results of that previous study have shown their potential use in newborns in particular premature newborns while the oral form containing phenobarbital is a tablet and is unsuitable for newborns. Thus, in order to have a suitable device for the administration of hydrogels oral formulations to newborns, we have done rheology studies to complement our work. For this we have studied the variation of the viscosity of hydrogels containing phenobarbital as a function of shear rate and time. Phenobarbital is an active drug used in neonatal treatment of epilepsy. The viscosity measurements of hydrogels are carried out using a Fungilab V'PAD Rotational Viscometer (100–240V/50–60Hz) Type 'R series then ANOVA test was used to analysis the results. The results showed that the hydrogels had a non-Newtonian behavior with shear-thinning and thixotropic type which depends on the chitosan concentration, the storage temperature hydrogels, the presence of Eudragit E100 and the final solution’s pH. Rheological properties study have shown that a syringe-type device would be suitable for oral administration of hydrogels formulations to neonates.
VL  - 9
IS  - 2
ER  -

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