@article{10.11648/j.ejb.20231101.12,
  author = {Papa Mady Sy and Alphonse Rodrigue Djiboune and Sidy Mouhamed Dieng and Boucar Ndong and El Hadji Amadou Lamine Bathily and Ousseynou Diop and Mamadou Soumboundou and Louis Augustin Diaga Diouf and Gora Mbaye and Mamadou Mbodj and Mounibé Diarra and Sylvie Seck Gassama},
  title = {Radiolabeling with Technetium 99m for the Diagnosis of Coronary Heart Disease in Senegal},
  journal = {European Journal of Biophysics},
  volume = {11},
  number = {1},
  pages = {17-24},
  doi = {10.11648/j.ejb.20231101.12},
  url = {https://doi.org/10.11648/j.ejb.20231101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20231101.12},
  abstract = {Coronary heart disease is the leading cause of death in industrialized countries. In Africa, its prevalence is increasing in line with the westernization of lifestyles, the improvement of socio-economic conditions and the increase in life expectancy. Therefore, myocardial perfusion scintigraphy presents itself as an effective imaging technique allowing improved prevention, diagnosis and therapeutic management and monitoring of patients at risk. Our present work has exclusively focused on the early diagnosis of patients at risk in the nuclear medicine department of the Grand Yoff General Hospital (HOGIP). Our work consisted of administering a radiopharmaceutical to a patient and monitoring its fate in the body by external detection of gamma radiation using a Mediso Nucline TM gamma camera. We used vectors like sestamibi and tetrofosmin. These vectors have the particularity of having an affinity and a tropism for the myocardial tissue. These two vectors were labeled with technetium 99m (radiotracer). Indeed, these radioactive tracers attach themselves to the organ to be studied from where they emit gamma radiation captured by a gamma camera which detects the signal from this organ and reconstructs a computerized static or dynamic image. This made it possible to make a diagnosis of ischemia or myocardial necrosis in 57% of cases in women and 82.5% of cases in men in a sample of 45 patients. Thanks to the qualitative visual interpretation of the distribution of the tracer, a diagnostic aid was provided by the semi-quantitative analysis provided by the study of the polar maps (bull's eyes). This myocardial perfusion scintigraphy can be a valuable diagnostic aid, especially in our countries where income is limited.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Radiolabeling with Technetium 99m for the Diagnosis of Coronary Heart Disease in Senegal
AU  - Papa Mady Sy
AU  - Alphonse Rodrigue Djiboune
AU  - Sidy Mouhamed Dieng
AU  - Boucar Ndong
AU  - El Hadji Amadou Lamine Bathily
AU  - Ousseynou Diop
AU  - Mamadou Soumboundou
AU  - Louis Augustin Diaga Diouf
AU  - Gora Mbaye
AU  - Mamadou Mbodj
AU  - Mounibé Diarra
AU  - Sylvie Seck Gassama
Y1  - 2023/05/24
PY  - 2023
N1  - https://doi.org/10.11648/j.ejb.20231101.12
DO  - 10.11648/j.ejb.20231101.12
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 17
EP  - 24
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20231101.12
AB  - Coronary heart disease is the leading cause of death in industrialized countries. In Africa, its prevalence is increasing in line with the westernization of lifestyles, the improvement of socio-economic conditions and the increase in life expectancy. Therefore, myocardial perfusion scintigraphy presents itself as an effective imaging technique allowing improved prevention, diagnosis and therapeutic management and monitoring of patients at risk. Our present work has exclusively focused on the early diagnosis of patients at risk in the nuclear medicine department of the Grand Yoff General Hospital (HOGIP). Our work consisted of administering a radiopharmaceutical to a patient and monitoring its fate in the body by external detection of gamma radiation using a Mediso Nucline TM gamma camera. We used vectors like sestamibi and tetrofosmin. These vectors have the particularity of having an affinity and a tropism for the myocardial tissue. These two vectors were labeled with technetium 99m (radiotracer). Indeed, these radioactive tracers attach themselves to the organ to be studied from where they emit gamma radiation captured by a gamma camera which detects the signal from this organ and reconstructs a computerized static or dynamic image. This made it possible to make a diagnosis of ischemia or myocardial necrosis in 57% of cases in women and 82.5% of cases in men in a sample of 45 patients. Thanks to the qualitative visual interpretation of the distribution of the tracer, a diagnostic aid was provided by the semi-quantitative analysis provided by the study of the polar maps (bull's eyes). This myocardial perfusion scintigraphy can be a valuable diagnostic aid, especially in our countries where income is limited.
VL  - 11
IS  - 1
ER  - 

Copy | Download