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Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms

Received: 17 August 2021    Accepted: 27 August 2021    Published: 23 November 2021
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Abstract

Objective: The increase in the diagnosis of tumors in early stages, associated with similar life expectations among the different treatments, create a challenge for both patients and treating doctors when choosing the best therapeutic option. The objective is to assess the impact on the quality of life in the sexual, intestinal and urinary fields in patients with localized prostate cancer who received treatment with modern radiotherapy. Methods: Descriptive observational study in which the validated EPIC-26 and SF-36 surveys were applied in the period between December 2015 and November 2018, in order to assess quality of life in men with localized prostate cancer before and after modern radiation therapy. Results: Surveys were applied to 70 individuals. In the EPIC-26 survey, relevant changes in the quality of life for urinary incontinence were found, with a previous average score of 81.75 (100 - 12.5) versus a subsequent 72.99 (100 - 0). In the SF-36 Health Questionnaire it was found that there is no significant difference in the overall quality of life, with an average score of 77 (99 - 31) and 76.63 (100 - 39.58) respectively. Conclusion: There is a tendency to oversize the impact of radiotherapy on the quality of life when there is a curative intent in patients with localized prostate cancer. Our study only demonstrated a clinically relevant difference in urinary incontinence, which allows us to suggest that most of the alterations in the quality of life could be secondary to natural changes in aging.

Published in European Journal of Clinical and Biomedical Sciences (Volume 7, Issue 6)
DOI 10.11648/j.ejcbs.20210706.12
Page(s) 94-98
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Intensity Modulated Radiotherapy, Radiotherapy, Quality of Life, Prostate Cancer, Lower Urinary Tract Symptoms, Erectile Dysfunction, Sexual Health, Radiation Effects

References
[1] Litwin MS. Health related quality of life in older men without prostate cancer. J Urol [Internet]. 1999 Apr [cited 2019 Nov 28]; 161 (4): 1180–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10081865.
[2] Ferrer M, Garin O, Pera J, et al. Evaluación de la calidad de vida de los pacientes con cáncer de próstata localizado: validación de la versión española del cuestionario EPIC. Med Clin (Barc). 2009 Feb 7; 132 (4): 128–35.
[3] Palvai S, Harrison M, Shibu Thomas S, et al. Timing of High-Dose Rate Brachytherapy With External Beam Radiotherapy in Intermediate and High-Risk Localized Prostate CAncer (THEPCA) Patients and Its Effects on Toxicity and Quality of Life: Protocol of a Randomized Feasibility Trial. JMIR Res Protoc. 2015 Apr 29; 4 (2): e49.
[4] Hanlon AL, Watkins Bruner D, Peter R, et al Quality of life study in prostate cancer patients treated with three-dimensional conformal radiation therapy: comparing late bowel and bladder quality of life symptoms to that of the normal population. Int J Radiat Oncol Biol Phys [Internet]. 2001 Jan 1 [cited 2019 Nov 28]; 49 (1): 51–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11163497.
[5] Nilsson S, Norlén BJ, Widmark A. A systematic overview of radiation therapy effects in prostate cancer. Vol. 43, Acta Oncologica. 2004. p. 316–81.
[6] Gomez-Veiga F, Ponce-Reixa J, Martinez-Breijo S, et al. Advances in prevention and treatment of bone metastases in prostate cancer. Role of RANK/RANKL inhibition. Actas Urol Esp. 2013 May; 37 (5): 292–304.
[7] Gó Mez-Veiga F, Cozar JM, Puyol-Pallas M, et al. Cuestionario Español de Calidad de Vida en Pacientes con Cáncer de Próstata como medida de la calidad de vida de los pacientes con cáncer de próstata en España aplicación a la actividad diaria. Actas Urol Esp [Internet]. 2010 [cited 2019 Nov 28]; 34: 686–93. Available from: www.elsevier.es/acuro.
[8] Lardas M, Liew M, van den Bergh RC, et al. Quality of Life Outcomes after Primary Treatment for Clinically Localised Prostate Cancer: A Systematic Review. Vol. 72, European Urology. Elsevier B. V.; 2017. p. 869–85.
[9] MacLennan S, Williamson PR, Bekema H, et al. A core outcome set for localised prostate cancer effectiveness trials. BJU Int. 2017 Nov 1; 120 (5): E64–79.
[10] Donovan JL, Hamdy FC, Lane JA, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. N Engl J Med [Internet]. 2016 Oct 13 [cited 2019 Nov 28]; 375 (15): 1425–37. Available from: http://www.nejm.org/doi/10.1056/NEJMoa1606221.
[11] Resnick MJ, Koyama T, Fan K-H, et al. Long-Term Functional Outcomes after Treatment for Localized Prostate Cancer. N Engl J Med [Internet]. 2013 Jan 31 [cited 2019 Nov 28]; 368 (5): 436–45. Available from: http://www.nejm.org/doi/10.1056/NEJMoa1209978.
[12] Wei JT, Dunn RL, Litwin MS, et al. Development and validation of the Expanded Prostate Cancer Index Composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology. 2000; 56 (6): 899–905.
[13] Popiolek M, Rider JR, Andrén O, et al. Natural history of early, localized prostate cancer: A final report from three decades of follow-up. Eur Urol. 2013 Mar; 63 (3): 428–35.
[14] Sánchez Basto C, Cataño Cataño J, Lizcano Herrera A, et al. Prostatectomía radical y calidad de vida: resultados en un centro de alta complejidad. Rev Urol Colomb / Colomb Urol J [Internet]. 2018 Aug 16 [cited 2019 Nov 29]; 27 (02): 141–6. Available from: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1648213.
[15] Litwin MS, Hays RD, Fink A, et al. Quality-of-Life Outcomes in Men Treated for Localized Prostate Cancer. JAMA J Am Med Assoc. 1995 Jan 11; 273 (2): 129–35.
[16] Skolarus TA, Dunn RL, Sanda MG, et al. Minimally important difference for the expanded prostate cancer index composite short form. Urology. 2015 Jan 1; 85 (1): 101–6.
Cite This Article
  • APA Style

    Isis Vargas, Andrea Araujo, Juan Guillermo Cataño, Ricardo Sánchez, Juan Carlos Galvis, et al. (2021). Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms. European Journal of Clinical and Biomedical Sciences, 7(6), 94-98. https://doi.org/10.11648/j.ejcbs.20210706.12

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    ACS Style

    Isis Vargas; Andrea Araujo; Juan Guillermo Cataño; Ricardo Sánchez; Juan Carlos Galvis, et al. Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms. Eur. J. Clin. Biomed. Sci. 2021, 7(6), 94-98. doi: 10.11648/j.ejcbs.20210706.12

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    AMA Style

    Isis Vargas, Andrea Araujo, Juan Guillermo Cataño, Ricardo Sánchez, Juan Carlos Galvis, et al. Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms. Eur J Clin Biomed Sci. 2021;7(6):94-98. doi: 10.11648/j.ejcbs.20210706.12

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  • @article{10.11648/j.ejcbs.20210706.12,
      author = {Isis Vargas and Andrea Araujo and Juan Guillermo Cataño and Ricardo Sánchez and Juan Carlos Galvis and Valeria Restrepo-Parra},
      title = {Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {7},
      number = {6},
      pages = {94-98},
      doi = {10.11648/j.ejcbs.20210706.12},
      url = {https://doi.org/10.11648/j.ejcbs.20210706.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20210706.12},
      abstract = {Objective: The increase in the diagnosis of tumors in early stages, associated with similar life expectations among the different treatments, create a challenge for both patients and treating doctors when choosing the best therapeutic option. The objective is to assess the impact on the quality of life in the sexual, intestinal and urinary fields in patients with localized prostate cancer who received treatment with modern radiotherapy. Methods: Descriptive observational study in which the validated EPIC-26 and SF-36 surveys were applied in the period between December 2015 and November 2018, in order to assess quality of life in men with localized prostate cancer before and after modern radiation therapy. Results: Surveys were applied to 70 individuals. In the EPIC-26 survey, relevant changes in the quality of life for urinary incontinence were found, with a previous average score of 81.75 (100 - 12.5) versus a subsequent 72.99 (100 - 0). In the SF-36 Health Questionnaire it was found that there is no significant difference in the overall quality of life, with an average score of 77 (99 - 31) and 76.63 (100 - 39.58) respectively. Conclusion: There is a tendency to oversize the impact of radiotherapy on the quality of life when there is a curative intent in patients with localized prostate cancer. Our study only demonstrated a clinically relevant difference in urinary incontinence, which allows us to suggest that most of the alterations in the quality of life could be secondary to natural changes in aging.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Quality of Life in Patients with Clinically Localized Prostate Cancer Managed with Modern Radiotherapy: Impact on Bowel Habit, Sexual Function and Urinary Symptoms
    AU  - Isis Vargas
    AU  - Andrea Araujo
    AU  - Juan Guillermo Cataño
    AU  - Ricardo Sánchez
    AU  - Juan Carlos Galvis
    AU  - Valeria Restrepo-Parra
    Y1  - 2021/11/23
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ejcbs.20210706.12
    DO  - 10.11648/j.ejcbs.20210706.12
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
    SP  - 94
    EP  - 98
    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20210706.12
    AB  - Objective: The increase in the diagnosis of tumors in early stages, associated with similar life expectations among the different treatments, create a challenge for both patients and treating doctors when choosing the best therapeutic option. The objective is to assess the impact on the quality of life in the sexual, intestinal and urinary fields in patients with localized prostate cancer who received treatment with modern radiotherapy. Methods: Descriptive observational study in which the validated EPIC-26 and SF-36 surveys were applied in the period between December 2015 and November 2018, in order to assess quality of life in men with localized prostate cancer before and after modern radiation therapy. Results: Surveys were applied to 70 individuals. In the EPIC-26 survey, relevant changes in the quality of life for urinary incontinence were found, with a previous average score of 81.75 (100 - 12.5) versus a subsequent 72.99 (100 - 0). In the SF-36 Health Questionnaire it was found that there is no significant difference in the overall quality of life, with an average score of 77 (99 - 31) and 76.63 (100 - 39.58) respectively. Conclusion: There is a tendency to oversize the impact of radiotherapy on the quality of life when there is a curative intent in patients with localized prostate cancer. Our study only demonstrated a clinically relevant difference in urinary incontinence, which allows us to suggest that most of the alterations in the quality of life could be secondary to natural changes in aging.
    VL  - 7
    IS  - 6
    ER  - 

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Author Information
  • Urology Department, San Ignacio Hospital, Pontifical Xaverian University, Bogotá, Colombia

  • Urology Department, San Ignacio Hospital, Pontifical Xaverian University, Bogotá, Colombia

  • Xaverian Center of Urology, San Ignacio Hospital, Pontifical Xaverian University, Bogotá, Colombia

  • Xaverian Center of Urology, San Ignacio Hospital, Pontifical Xaverian University, Bogotá, Colombia

  • Urology Department, San Ignacio Hospital, Pontifical Xaverian University, Bogotá, Colombia

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