Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia

Salil Vaniawala; Pratik Chavda; Ganesh Jori; Keur Patil; Pankaj Gadhia

doi:doi:10.11648/j.ijcems.20150102.16

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Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia

Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 2)

Received: 19 June 2015 Accepted: 30 June 2015 Published: 2 July 2015

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Abstract

The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 2)
DOI	10.11648/j.ijcems.20150102.16
Page(s)	30-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Chronic Myeloid Leukemia, t(9;22), Three-Way Translocation Variant, FISH, Cytogenetic

References

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[11]	Hagemeijer A, Bartram CR, Smit EME, Van Agthoven AS, Boostama D. Is the chromosome region 9q34 always involved in variant of the Ph1 Translocation?Can. Genet.Cytogent.1984; 13: 1-16.
[12]	Aventin A, Mecucci C, Louwagie A, Shutyers J, Van Den Berghe H, Bandeo de altaresolucion en el analisiscitogenetico de la leucemiamioloide Cronica con translocacioncompleja. Sangre. 1987; 32: 6-11.
[13]	Calabrese G, Stuppia L, Franchi PG, Pelia R, Martizio E, Liberati M, Spadano A, Di Loenzo R, Donti E, Antonucci A. Complex translocations of the Ph negative CML arise from similar mechanism as evidenced by FISH analysis Can. Genet.Cytogenet. 1994; 78(2): 153-159.
[14]	Gudi R, Elizalde A, Gogeneni SK, Macera MJ, Badillo A, Verma RS Characterization of a complex translocation [t(4;9;22)(p16;q32;q11) ] inChronic myelogenousleukemia by fluorescence in situ hybridization technique.Can. Genet.Cytogenet.1996; 90: 142-145.
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APA Style

Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. (2015). Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. International Journal of Clinical and Experimental Medical Sciences, 1(2), 30-34. https://doi.org/10.11648/j.ijcems.20150102.16

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ACS Style

Salil Vaniawala; Pratik Chavda; Ganesh Jori; Keur Patil; Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int. J. Clin. Exp. Med. Sci. 2015, 1(2), 30-34. doi: 10.11648/j.ijcems.20150102.16

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AMA Style

Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int J Clin Exp Med Sci. 2015;1(2):30-34. doi: 10.11648/j.ijcems.20150102.16

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@article{10.11648/j.ijcems.20150102.16,
  author = {Salil Vaniawala and Pratik Chavda and Ganesh Jori and Keur Patil and Pankaj Gadhia},
  title = {Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {1},
  number = {2},
  pages = {30-34},
  doi = {10.11648/j.ijcems.20150102.16},
  url = {https://doi.org/10.11648/j.ijcems.20150102.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150102.16},
  abstract = {The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.},
 year = {2015}
}

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TY  - JOUR
T1  - Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia
AU  - Salil Vaniawala
AU  - Pratik Chavda
AU  - Ganesh Jori
AU  - Keur Patil
AU  - Pankaj Gadhia
Y1  - 2015/07/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ijcems.20150102.16
DO  - 10.11648/j.ijcems.20150102.16
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 30
EP  - 34
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20150102.16
AB  - The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.
VL  - 1
IS  - 2
ER  -

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Author Information

Salil Vaniawala

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Pratik Chavda

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Ganesh Jori

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Keur Patil

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Pankaj Gadhia

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

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Plain Text BibTeX RIS

APA Style

Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. (2015). Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. International Journal of Clinical and Experimental Medical Sciences, 1(2), 30-34. https://doi.org/10.11648/j.ijcems.20150102.16

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ACS Style

Salil Vaniawala; Pratik Chavda; Ganesh Jori; Keur Patil; Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int. J. Clin. Exp. Med. Sci. 2015, 1(2), 30-34. doi: 10.11648/j.ijcems.20150102.16

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AMA Style

Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int J Clin Exp Med Sci. 2015;1(2):30-34. doi: 10.11648/j.ijcems.20150102.16

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@article{10.11648/j.ijcems.20150102.16,
  author = {Salil Vaniawala and Pratik Chavda and Ganesh Jori and Keur Patil and Pankaj Gadhia},
  title = {Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {1},
  number = {2},
  pages = {30-34},
  doi = {10.11648/j.ijcems.20150102.16},
  url = {https://doi.org/10.11648/j.ijcems.20150102.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150102.16},
  abstract = {The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.},
 year = {2015}
}

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TY  - JOUR
T1  - Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia
AU  - Salil Vaniawala
AU  - Pratik Chavda
AU  - Ganesh Jori
AU  - Keur Patil
AU  - Pankaj Gadhia
Y1  - 2015/07/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ijcems.20150102.16
DO  - 10.11648/j.ijcems.20150102.16
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 30
EP  - 34
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20150102.16
AB  - The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.
VL  - 1
IS  - 2
ER  -

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