Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand

Joyce Akwe; Amy Miller

doi:doi:10.11648/j.ijcems.20160204.12

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Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand

Joyce Akwe, Amy Miller

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 4)

Received: 25 May 2016 Accepted: 3 June 2016 Published: 5 July 2016

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Abstract

Asthma-Chronic obstructive pulmonary disease overlap syndrome (ACOS) or ASCOS is a frequently encountered clinical syndrome. It is identified by the clinical features that it shares with asthma and COPD. There is no clear consensus definition yet for this medical syndrome. ACOS has not been extensively studied partly because of the absence of clarity of its clinical significance and because of the lack of a clear definition for this syndrome. ACOS is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with chronic obstructive pulmonary disease (COPD). It has been described and named differently by different authors. Some of the commonly encountered names are asthmatic bronchitis, asthma of the elderly, patients with COPD and a prominent asthmatic component, asthma that complicates COPD, asthma with permanent obstruction, COPD with a reversible component and asthma-COPD overlap syndrome. In most obstructive lung disease trials patients with overlap syndrome are excluded because they are not strictly asthmatic per the study inclusion criteria or they are not strictly chronic obstructive pulmonary disease patients. With no clear consensus on the definition and few studies on its genetics or pathophysiology, it is difficult to create management guidelines for this group of patients. Patients with ACOS have been found to have higher risk not only for exacerbations, but also for hospitalizations. Global Initiative for Chronic Obstructive Lung Disease (Gold) and the Global Initiative for Asthma (GINA) have suggested a stepwise diagnostic and management criteria for patients with ACOS.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 4)
DOI	10.11648/j.ijcems.20160204.12
Page(s)	59-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Asthma COPD Overlap Syndrome (ACOS), Definition, Pathophysiology, Approach, Management

References

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APA Style

Joyce Akwe, Amy Miller. (2016). Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. International Journal of Clinical and Experimental Medical Sciences, 2(4), 59-66. https://doi.org/10.11648/j.ijcems.20160204.12

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ACS Style

Joyce Akwe; Amy Miller. Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. Int. J. Clin. Exp. Med. Sci. 2016, 2(4), 59-66. doi: 10.11648/j.ijcems.20160204.12

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AMA Style

Joyce Akwe, Amy Miller. Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. Int J Clin Exp Med Sci. 2016;2(4):59-66. doi: 10.11648/j.ijcems.20160204.12

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@article{10.11648/j.ijcems.20160204.12,
  author = {Joyce Akwe and Amy Miller},
  title = {Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {2},
  number = {4},
  pages = {59-66},
  doi = {10.11648/j.ijcems.20160204.12},
  url = {https://doi.org/10.11648/j.ijcems.20160204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160204.12},
  abstract = {Asthma-Chronic obstructive pulmonary disease overlap syndrome (ACOS) or ASCOS is a frequently encountered clinical syndrome. It is identified by the clinical features that it shares with asthma and COPD. There is no clear consensus definition yet for this medical syndrome. ACOS has not been extensively studied partly because of the absence of clarity of its clinical significance and because of the lack of a clear definition for this syndrome. ACOS is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with chronic obstructive pulmonary disease (COPD). It has been described and named differently by different authors. Some of the commonly encountered names are asthmatic bronchitis, asthma of the elderly, patients with COPD and a prominent asthmatic component, asthma that complicates COPD, asthma with permanent obstruction, COPD with a reversible component and asthma-COPD overlap syndrome. In most obstructive lung disease trials patients with overlap syndrome are excluded because they are not strictly asthmatic per the study inclusion criteria or they are not strictly chronic obstructive pulmonary disease patients. With no clear consensus on the definition and few studies on its genetics or pathophysiology, it is difficult to create management guidelines for this group of patients. Patients with ACOS have been found to have higher risk not only for exacerbations, but also for hospitalizations. Global Initiative for Chronic Obstructive Lung Disease (Gold) and the Global Initiative for Asthma (GINA) have suggested a stepwise diagnostic and management criteria for patients with ACOS.},
 year = {2016}
}

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TY  - JOUR
T1  - Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand
AU  - Joyce Akwe
AU  - Amy Miller
Y1  - 2016/07/05
PY  - 2016
N1  - https://doi.org/10.11648/j.ijcems.20160204.12
DO  - 10.11648/j.ijcems.20160204.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 59
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20160204.12
AB  - Asthma-Chronic obstructive pulmonary disease overlap syndrome (ACOS) or ASCOS is a frequently encountered clinical syndrome. It is identified by the clinical features that it shares with asthma and COPD. There is no clear consensus definition yet for this medical syndrome. ACOS has not been extensively studied partly because of the absence of clarity of its clinical significance and because of the lack of a clear definition for this syndrome. ACOS is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with chronic obstructive pulmonary disease (COPD). It has been described and named differently by different authors. Some of the commonly encountered names are asthmatic bronchitis, asthma of the elderly, patients with COPD and a prominent asthmatic component, asthma that complicates COPD, asthma with permanent obstruction, COPD with a reversible component and asthma-COPD overlap syndrome. In most obstructive lung disease trials patients with overlap syndrome are excluded because they are not strictly asthmatic per the study inclusion criteria or they are not strictly chronic obstructive pulmonary disease patients. With no clear consensus on the definition and few studies on its genetics or pathophysiology, it is difficult to create management guidelines for this group of patients. Patients with ACOS have been found to have higher risk not only for exacerbations, but also for hospitalizations. Global Initiative for Chronic Obstructive Lung Disease (Gold) and the Global Initiative for Asthma (GINA) have suggested a stepwise diagnostic and management criteria for patients with ACOS.
VL  - 2
IS  - 4
ER  -

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Author Information

Joyce Akwe

Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Department of Medicine, Atlanta GA, USA
Amy Miller

Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Department of Medicine, Atlanta GA, USA

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Plain Text BibTeX RIS

APA Style

Joyce Akwe, Amy Miller. (2016). Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. International Journal of Clinical and Experimental Medical Sciences, 2(4), 59-66. https://doi.org/10.11648/j.ijcems.20160204.12

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ACS Style

Joyce Akwe; Amy Miller. Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. Int. J. Clin. Exp. Med. Sci. 2016, 2(4), 59-66. doi: 10.11648/j.ijcems.20160204.12

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AMA Style

Joyce Akwe, Amy Miller. Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand. Int J Clin Exp Med Sci. 2016;2(4):59-66. doi: 10.11648/j.ijcems.20160204.12

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@article{10.11648/j.ijcems.20160204.12,
  author = {Joyce Akwe and Amy Miller},
  title = {Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {2},
  number = {4},
  pages = {59-66},
  doi = {10.11648/j.ijcems.20160204.12},
  url = {https://doi.org/10.11648/j.ijcems.20160204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160204.12},
  abstract = {Asthma-Chronic obstructive pulmonary disease overlap syndrome (ACOS) or ASCOS is a frequently encountered clinical syndrome. It is identified by the clinical features that it shares with asthma and COPD. There is no clear consensus definition yet for this medical syndrome. ACOS has not been extensively studied partly because of the absence of clarity of its clinical significance and because of the lack of a clear definition for this syndrome. ACOS is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with chronic obstructive pulmonary disease (COPD). It has been described and named differently by different authors. Some of the commonly encountered names are asthmatic bronchitis, asthma of the elderly, patients with COPD and a prominent asthmatic component, asthma that complicates COPD, asthma with permanent obstruction, COPD with a reversible component and asthma-COPD overlap syndrome. In most obstructive lung disease trials patients with overlap syndrome are excluded because they are not strictly asthmatic per the study inclusion criteria or they are not strictly chronic obstructive pulmonary disease patients. With no clear consensus on the definition and few studies on its genetics or pathophysiology, it is difficult to create management guidelines for this group of patients. Patients with ACOS have been found to have higher risk not only for exacerbations, but also for hospitalizations. Global Initiative for Chronic Obstructive Lung Disease (Gold) and the Global Initiative for Asthma (GINA) have suggested a stepwise diagnostic and management criteria for patients with ACOS.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS): Where We Stand
AU  - Joyce Akwe
AU  - Amy Miller
Y1  - 2016/07/05
PY  - 2016
N1  - https://doi.org/10.11648/j.ijcems.20160204.12
DO  - 10.11648/j.ijcems.20160204.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 59
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20160204.12
AB  - Asthma-Chronic obstructive pulmonary disease overlap syndrome (ACOS) or ASCOS is a frequently encountered clinical syndrome. It is identified by the clinical features that it shares with asthma and COPD. There is no clear consensus definition yet for this medical syndrome. ACOS has not been extensively studied partly because of the absence of clarity of its clinical significance and because of the lack of a clear definition for this syndrome. ACOS is characterized by persistent airflow limitation with several features usually associated with asthma and several features usually associated with chronic obstructive pulmonary disease (COPD). It has been described and named differently by different authors. Some of the commonly encountered names are asthmatic bronchitis, asthma of the elderly, patients with COPD and a prominent asthmatic component, asthma that complicates COPD, asthma with permanent obstruction, COPD with a reversible component and asthma-COPD overlap syndrome. In most obstructive lung disease trials patients with overlap syndrome are excluded because they are not strictly asthmatic per the study inclusion criteria or they are not strictly chronic obstructive pulmonary disease patients. With no clear consensus on the definition and few studies on its genetics or pathophysiology, it is difficult to create management guidelines for this group of patients. Patients with ACOS have been found to have higher risk not only for exacerbations, but also for hospitalizations. Global Initiative for Chronic Obstructive Lung Disease (Gold) and the Global Initiative for Asthma (GINA) have suggested a stepwise diagnostic and management criteria for patients with ACOS.
VL  - 2
IS  - 4
ER  -

Copy | Download