A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies

Shashidhar Kallappa; Navaneetha Kallidil Kallavalappil

doi:doi:10.11648/j.ijcocr.20210602.11

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A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies

Shashidhar Kallappa, Navaneetha Kallidil Kallavalappil

Published in International Journal of Clinical Oncology and Cancer Research (Volume 6, Issue 2)

Received: 12 March 2021 Accepted: 27 March 2021 Published: 7 April 2021

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Abstract

Background: Carcinoma larynx is one among the most common head and neck malignancy which accounts for 2% of all cancers whereas hypopharyngeal cancer is one of the most aggressive tumor with poorer prognosis. Total laryngectomy/laryngopharyngectomy (TL/TLP) is the treatment of choice for locally advanced laryngeal and hypopharyngeal cancers. Objectives: To study the complications associated with primary TL/TLP along with the sociodemographic profile and clinicopathologic features of laryngeal and hypopharyngeal cancers. We also aimed to assess the risk factors associated with complications. Methods: All stage III or IVA laryngeal and hypopharyngeal malignancy cases as per American Joint Committee on Cancer (AJCC) 8^th edition staging, who underwent primary total laryngectomy/total laryngopharyngectomy during the year 2018-2019 in our institute, KIMS Hubli, have been studied. Sociodemographic profile and clinicopathological features were noted. These patients were followed up for 6 months for any local complications. Results: Mean age of the study population was 58 years with male predominance. Primary glottic carcinoma was most common. Most common presenting symptom was change in voice and most common anatomical site involved was true cords. Overall complication rate was 32%. Most common complication encountered was wound infection and pharyngocutaneous fistula (8% each). As complications set in length of hospital stay increases. We found significant association with PCF and length of hospital stay. Conclusion: With proper case selection, and regular wound care, complications can be avoided in case of TL/TLP. Once complications set in, it increases hospital stay and the expenditure, hence is traumatizing to the patient and hence should be avoided.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 6, Issue 2)
DOI	10.11648/j.ijcocr.20210602.11
Page(s)	49-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Laryngectomy, Carcinoma, Larynx, Hypopharynx, Complications

References

[1]	Varghese BT, Babu S, Desai KP, Bava AS, George P, Iype EM, Rajan B, Sebastian P. Prospective study of outcomes of surgically treated larynx and hypopharyngeal cancers. Indian journal of cancer. 2014 Apr 1; 51 (2): 104.
[2]	Larbcharoensub N, Wattanatranon D, Leopairut J, Suntisuktana S, Roongpupaht B, Chintrakarn C, Tungkeeratichai J, Praneetvatakul P, Bhongmakapat T, Cheewaruangroj W, Prakunhungsit S. Clinicopathologic Findings and Treatment Outcome of Laryngectomized Patients with Laryngeal Cancer and Hypopharyngeal Cancer: An Experience in Thailand. Asian Pacific Journal of Cancer Prevention: APJCP. 2017; 18 (8): 2035.
[3]	Varghese BT, Sebastian P, Mathew A. Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx–a follow-up study. Acta oto-laryngologica. 2009 Jan 1; 129 (12): 1480-5.
[4]	Watkinson J, Gilbert R. Stell & Maran's textbook of head and neck surgery and oncology. CRC Press; 2011 Dec 30.
[5]	Ramakodi MP, Kulathinal RJ, Chung Y, Serebriiskii I, Liu JC, Ragin CC. Ancestral-derived effects on the mutational landscape of laryngeal cancer. Genomics. 2016 Mar 1; 107 (2-3): 76-82.
[6]	Alagic-Smailbegovic J, Kapidzic A, Sutalo K, Resic M, Hadzic E. Incidence of malignant tumors of larynx and their treatment. Bosnian journal of basic medical sciences. 2004 Nov; 4 (4): 25.
[7]	Villanueva-Reyes A, Strand E, Nazario CM, Irizarry-Ramirez M. Cancer of the larynx in Puerto Rico. Puerto Rico health sciences journal. 2008 Sep; 27 (3): 196.
[8]	Grignoux J, Durand-Moreau Q, Vongmany N, Brunel S, Dewitte JD. Work-related laryngeal cancer: Trends in France from 2001 to 2016. European annals of otorhinolaryngology, head and neck diseases. 2019 Feb 1; 136 (1): 7-12.
[9]	Amin MB, Edge SB, editors. AJCC Cancer staging manual. springer; 2017.
[10]	Goepfert RP, Hutcheson KA, Lewin JS, Desai NG, Zafereo ME, Hessel AC, Lewis CM, Weber RS, Gross ND. Complications, hospital length of stay, and readmission after total laryngectomy. Cancer. 2017 May 15; 123 (10): 1760-7.
[11]	Staffieri A, Mostafea BE, Varghese BT, Kitcher ED, Jalisi M, Fagan JJ, Staffieri C, Marioni G. Cost of tracheoesophageal prostheses in developing countries. Facing the problem from an internal perspective.
[12]	Sakai A, Okami K, Sugimoto R, Ebisumoto K, Yamamoto H, Furuya H, Iida M. Multivariate analysis of wound complications after surgery for laryngeal and hypopharyngeal cancers. ORL. 2011; 73 (2): 100-4.
[13]	Maharjan R, Adhikari P, Khalilullah S, Sinha BK, Baskota DK. Early complications of total laryngectomy: a retrospective study. Nepalese Journal of ENT Head and Neck Surgery. 2010; 1 (2): 17-8.
[14]	Reddy SL, Reddy SD, Prasad AV. A Prospective Study of Total Laryngectomy and associated Complications. Int J Phonosurg Laryngol. 2012; 2 (1): 20-2.
[15]	Atikuzzaman K, Ahmed KU, Hassan M. Postoperative complications and its management after total laryngectomy. Bangladesh Journal of Otorhinolaryngology. 2013; 19 (2): 82-6.
[16]	Liang J, Zhu X, Zeng W, Yu T, Fang F, Zhao Y. Which risk factors are associated with stomal recurrence after total laryngectomy for laryngeal cancer? A meta-analysis of the last 30 years. Brazilian journal of otorhinolaryngology. 2020 Apr 11.
[17]	Herrero PG, Fernández-Vañes L, Álvarez FL, Marcos CÁ, Llorente JL, Rodrigo JP. Results of total laryngectomy as treatment for locally advanced hypopharyngeal cancer. Acta Otorrinolaringologica (English Edition). 2017 Nov 1; 68 (6): 328-35.

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APA Style

Shashidhar Kallappa, Navaneetha Kallidil Kallavalappil. (2021). A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. International Journal of Clinical Oncology and Cancer Research, 6(2), 49-55. https://doi.org/10.11648/j.ijcocr.20210602.11

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ACS Style

Shashidhar Kallappa; Navaneetha Kallidil Kallavalappil. A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. Int. J. Clin. Oncol. Cancer Res. 2021, 6(2), 49-55. doi: 10.11648/j.ijcocr.20210602.11

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AMA Style

Shashidhar Kallappa, Navaneetha Kallidil Kallavalappil. A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. Int J Clin Oncol Cancer Res. 2021;6(2):49-55. doi: 10.11648/j.ijcocr.20210602.11

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@article{10.11648/j.ijcocr.20210602.11,
  author = {Shashidhar Kallappa and Navaneetha Kallidil Kallavalappil},
  title = {A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {6},
  number = {2},
  pages = {49-55},
  doi = {10.11648/j.ijcocr.20210602.11},
  url = {https://doi.org/10.11648/j.ijcocr.20210602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20210602.11},
  abstract = {Background: Carcinoma larynx is one among the most common head and neck malignancy which accounts for 2% of all cancers whereas hypopharyngeal cancer is one of the most aggressive tumor with poorer prognosis. Total laryngectomy/laryngopharyngectomy (TL/TLP) is the treatment of choice for locally advanced laryngeal and hypopharyngeal cancers. Objectives: To study the complications associated with primary TL/TLP along with the sociodemographic profile and clinicopathologic features of laryngeal and hypopharyngeal cancers. We also aimed to assess the risk factors associated with complications. Methods: All stage III or IVA laryngeal and hypopharyngeal malignancy cases as per American Joint Committee on Cancer (AJCC) 8th edition staging, who underwent primary total laryngectomy/total laryngopharyngectomy during the year 2018-2019 in our institute, KIMS Hubli, have been studied. Sociodemographic profile and clinicopathological features were noted. These patients were followed up for 6 months for any local complications. Results: Mean age of the study population was 58 years with male predominance. Primary glottic carcinoma was most common. Most common presenting symptom was change in voice and most common anatomical site involved was true cords. Overall complication rate was 32%. Most common complication encountered was wound infection and pharyngocutaneous fistula (8% each). As complications set in length of hospital stay increases. We found significant association with PCF and length of hospital stay. Conclusion: With proper case selection, and regular wound care, complications can be avoided in case of TL/TLP. Once complications set in, it increases hospital stay and the expenditure, hence is traumatizing to the patient and hence should be avoided.},
 year = {2021}
}

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TY - JOUR
T1 - A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies
AU - Shashidhar Kallappa
AU - Navaneetha Kallidil Kallavalappil
Y1 - 2021/04/07
PY - 2021
N1 - https://doi.org/10.11648/j.ijcocr.20210602.11
DO - 10.11648/j.ijcocr.20210602.11
T2 - International Journal of Clinical Oncology and Cancer Research
JF - International Journal of Clinical Oncology and Cancer Research
JO - International Journal of Clinical Oncology and Cancer Research
SP - 49
EP - 55
PB - Science Publishing Group
SN - 2578-9511
UR - https://doi.org/10.11648/j.ijcocr.20210602.11
AB - Background: Carcinoma larynx is one among the most common head and neck malignancy which accounts for 2% of all cancers whereas hypopharyngeal cancer is one of the most aggressive tumor with poorer prognosis. Total laryngectomy/laryngopharyngectomy (TL/TLP) is the treatment of choice for locally advanced laryngeal and hypopharyngeal cancers. Objectives: To study the complications associated with primary TL/TLP along with the sociodemographic profile and clinicopathologic features of laryngeal and hypopharyngeal cancers. We also aimed to assess the risk factors associated with complications. Methods: All stage III or IVA laryngeal and hypopharyngeal malignancy cases as per American Joint Committee on Cancer (AJCC) 8th edition staging, who underwent primary total laryngectomy/total laryngopharyngectomy during the year 2018-2019 in our institute, KIMS Hubli, have been studied. Sociodemographic profile and clinicopathological features were noted. These patients were followed up for 6 months for any local complications. Results: Mean age of the study population was 58 years with male predominance. Primary glottic carcinoma was most common. Most common presenting symptom was change in voice and most common anatomical site involved was true cords. Overall complication rate was 32%. Most common complication encountered was wound infection and pharyngocutaneous fistula (8% each). As complications set in length of hospital stay increases. We found significant association with PCF and length of hospital stay. Conclusion: With proper case selection, and regular wound care, complications can be avoided in case of TL/TLP. Once complications set in, it increases hospital stay and the expenditure, hence is traumatizing to the patient and hence should be avoided.
VL - 6
IS - 2
ER -

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Author Information

Shashidhar Kallappa

Department of Surgical Oncology, Karnataka Institute of Medical Sciences, Hubli, India
Navaneetha Kallidil Kallavalappil

Department of Otorhinolaryngology, Karnataka Institute of Medical Sciences, Hubli, India

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APA Style

Shashidhar Kallappa, Navaneetha Kallidil Kallavalappil. (2021). A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. International Journal of Clinical Oncology and Cancer Research, 6(2), 49-55. https://doi.org/10.11648/j.ijcocr.20210602.11

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ACS Style

Shashidhar Kallappa; Navaneetha Kallidil Kallavalappil. A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. Int. J. Clin. Oncol. Cancer Res. 2021, 6(2), 49-55. doi: 10.11648/j.ijcocr.20210602.11

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AMA Style

Shashidhar Kallappa, Navaneetha Kallidil Kallavalappil. A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies. Int J Clin Oncol Cancer Res. 2021;6(2):49-55. doi: 10.11648/j.ijcocr.20210602.11

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@article{10.11648/j.ijcocr.20210602.11,
  author = {Shashidhar Kallappa and Navaneetha Kallidil Kallavalappil},
  title = {A Prospective Study on Local Complications of Primary Total Laryngectomy/Laryngopharyngectomy for Laryngeal and Hypopharyngeal Malignancies},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {6},
  number = {2},
  pages = {49-55},
  doi = {10.11648/j.ijcocr.20210602.11},
  url = {https://doi.org/10.11648/j.ijcocr.20210602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20210602.11},
  abstract = {Background: Carcinoma larynx is one among the most common head and neck malignancy which accounts for 2% of all cancers whereas hypopharyngeal cancer is one of the most aggressive tumor with poorer prognosis. Total laryngectomy/laryngopharyngectomy (TL/TLP) is the treatment of choice for locally advanced laryngeal and hypopharyngeal cancers. Objectives: To study the complications associated with primary TL/TLP along with the sociodemographic profile and clinicopathologic features of laryngeal and hypopharyngeal cancers. We also aimed to assess the risk factors associated with complications. Methods: All stage III or IVA laryngeal and hypopharyngeal malignancy cases as per American Joint Committee on Cancer (AJCC) 8th edition staging, who underwent primary total laryngectomy/total laryngopharyngectomy during the year 2018-2019 in our institute, KIMS Hubli, have been studied. Sociodemographic profile and clinicopathological features were noted. These patients were followed up for 6 months for any local complications. Results: Mean age of the study population was 58 years with male predominance. Primary glottic carcinoma was most common. Most common presenting symptom was change in voice and most common anatomical site involved was true cords. Overall complication rate was 32%. Most common complication encountered was wound infection and pharyngocutaneous fistula (8% each). As complications set in length of hospital stay increases. We found significant association with PCF and length of hospital stay. Conclusion: With proper case selection, and regular wound care, complications can be avoided in case of TL/TLP. Once complications set in, it increases hospital stay and the expenditure, hence is traumatizing to the patient and hence should be avoided.},
 year = {2021}
}

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