Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats

Mahmoud H. El-Bidawy

doi:doi:10.11648/j.ijde.20180303.12

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Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats

Mahmoud H. El-Bidawy

Published in International Journal of Diabetes and Endocrinology (Volume 3, Issue 3)

Received: 17 September 2018 Accepted: 11 October 2018 Published: 7 November 2018

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Abstract

Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Insulin resistance is the key pathology in type 2 diabetes negatively influence bone remodeling and leads to reduced bone strength. Loss of sex steroids, particularly oestradiol, as in ovariectomized rats,leads to increased skeletal remodeling over and above the age-related increment, together with excessive osteoclast activity. In this study, ovariectomy DEX group has highly significant increase in relative cortical resorptioncompared to ovaiectomy and sham DEX groups, also ovariectomy and DEX group has highly significant decrease in bone thickness compared to ovariectomy and sham DEX groups. The consequent increase in remodeling activation increases the overall resorption rate without a compensatory increase in formation, leading to rapid bone loss.This negative effect on bone which is due to the glucocorticoid excess is also mediated by indirect mechanisms such as the calcium malabsorption and hypercalciuria. In response to the enhanced supply of calcium from the skeleton, PTH secretion tends to be diminished, thereby reducing vitamin D [1,25(OH)2 cholecalciferol] concentration with a consequent reduction in calcium absorption.

Published in	International Journal of Diabetes and Endocrinology (Volume 3, Issue 3)
DOI	10.11648/j.ijde.20180303.12
Page(s)	41-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Dexamethasone, Insulin Resistance, Ovariectomy, Bone Mass, Osteoporosis

References

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APA Style

Mahmoud H. El-Bidawy. (2018). Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. International Journal of Diabetes and Endocrinology, 3(3), 41-49. https://doi.org/10.11648/j.ijde.20180303.12

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ACS Style

Mahmoud H. El-Bidawy. Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. Int. J. Diabetes Endocrinol. 2018, 3(3), 41-49. doi: 10.11648/j.ijde.20180303.12

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AMA Style

Mahmoud H. El-Bidawy. Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. Int J Diabetes Endocrinol. 2018;3(3):41-49. doi: 10.11648/j.ijde.20180303.12

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@article{10.11648/j.ijde.20180303.12,
  author = {Mahmoud H. El-Bidawy},
  title = {Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {3},
  number = {3},
  pages = {41-49},
  doi = {10.11648/j.ijde.20180303.12},
  url = {https://doi.org/10.11648/j.ijde.20180303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20180303.12},
  abstract = {Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Insulin resistance is the key pathology in type 2 diabetes negatively influence bone remodeling and leads to reduced bone strength. Loss of sex steroids, particularly oestradiol, as in ovariectomized rats,leads to increased skeletal remodeling over and above the age-related increment, together with excessive osteoclast activity. In this study, ovariectomy DEX group has highly significant increase in relative cortical resorptioncompared to ovaiectomy and sham DEX groups, also ovariectomy and DEX group has highly significant decrease in bone thickness compared to ovariectomy and sham DEX groups. The consequent increase in remodeling activation increases the overall resorption rate without a compensatory increase in formation, leading to rapid bone loss.This negative effect on bone which is due to the glucocorticoid excess is also mediated by indirect mechanisms such as the calcium malabsorption and hypercalciuria. In response to the enhanced supply of calcium from the skeleton, PTH secretion tends to be diminished, thereby reducing vitamin D [1,25(OH)2 cholecalciferol] concentration with a consequent reduction in calcium absorption.},
 year = {2018}
}

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TY  - JOUR
T1  - Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats
AU  - Mahmoud H. El-Bidawy
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.ijde.20180303.12
DO  - 10.11648/j.ijde.20180303.12
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 41
EP  - 49
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20180303.12
AB  - Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Insulin resistance is the key pathology in type 2 diabetes negatively influence bone remodeling and leads to reduced bone strength. Loss of sex steroids, particularly oestradiol, as in ovariectomized rats,leads to increased skeletal remodeling over and above the age-related increment, together with excessive osteoclast activity. In this study, ovariectomy DEX group has highly significant increase in relative cortical resorptioncompared to ovaiectomy and sham DEX groups, also ovariectomy and DEX group has highly significant decrease in bone thickness compared to ovariectomy and sham DEX groups. The consequent increase in remodeling activation increases the overall resorption rate without a compensatory increase in formation, leading to rapid bone loss.This negative effect on bone which is due to the glucocorticoid excess is also mediated by indirect mechanisms such as the calcium malabsorption and hypercalciuria. In response to the enhanced supply of calcium from the skeleton, PTH secretion tends to be diminished, thereby reducing vitamin D [1,25(OH)2 cholecalciferol] concentration with a consequent reduction in calcium absorption.
VL  - 3
IS  - 3
ER  -

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Author Information

Mahmoud H. El-Bidawy

Department of BMS, Division of Physiology, College of Medicine, Prince Sattam Ibn Abdulaziz University, AlKharj, Saudi Arabia

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APA Style

Mahmoud H. El-Bidawy. (2018). Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. International Journal of Diabetes and Endocrinology, 3(3), 41-49. https://doi.org/10.11648/j.ijde.20180303.12

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ACS Style

Mahmoud H. El-Bidawy. Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. Int. J. Diabetes Endocrinol. 2018, 3(3), 41-49. doi: 10.11648/j.ijde.20180303.12

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AMA Style

Mahmoud H. El-Bidawy. Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats. Int J Diabetes Endocrinol. 2018;3(3):41-49. doi: 10.11648/j.ijde.20180303.12

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@article{10.11648/j.ijde.20180303.12,
  author = {Mahmoud H. El-Bidawy},
  title = {Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {3},
  number = {3},
  pages = {41-49},
  doi = {10.11648/j.ijde.20180303.12},
  url = {https://doi.org/10.11648/j.ijde.20180303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20180303.12},
  abstract = {Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Insulin resistance is the key pathology in type 2 diabetes negatively influence bone remodeling and leads to reduced bone strength. Loss of sex steroids, particularly oestradiol, as in ovariectomized rats,leads to increased skeletal remodeling over and above the age-related increment, together with excessive osteoclast activity. In this study, ovariectomy DEX group has highly significant increase in relative cortical resorptioncompared to ovaiectomy and sham DEX groups, also ovariectomy and DEX group has highly significant decrease in bone thickness compared to ovariectomy and sham DEX groups. The consequent increase in remodeling activation increases the overall resorption rate without a compensatory increase in formation, leading to rapid bone loss.This negative effect on bone which is due to the glucocorticoid excess is also mediated by indirect mechanisms such as the calcium malabsorption and hypercalciuria. In response to the enhanced supply of calcium from the skeleton, PTH secretion tends to be diminished, thereby reducing vitamin D [1,25(OH)2 cholecalciferol] concentration with a consequent reduction in calcium absorption.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Effects of Insulin Resistance Induced by Dexamethasone on Bone Mass in Ovariectomized Rats
AU  - Mahmoud H. El-Bidawy
Y1  - 2018/11/07
PY  - 2018
N1  - https://doi.org/10.11648/j.ijde.20180303.12
DO  - 10.11648/j.ijde.20180303.12
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 41
EP  - 49
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20180303.12
AB  - Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Insulin resistance is the key pathology in type 2 diabetes negatively influence bone remodeling and leads to reduced bone strength. Loss of sex steroids, particularly oestradiol, as in ovariectomized rats,leads to increased skeletal remodeling over and above the age-related increment, together with excessive osteoclast activity. In this study, ovariectomy DEX group has highly significant increase in relative cortical resorptioncompared to ovaiectomy and sham DEX groups, also ovariectomy and DEX group has highly significant decrease in bone thickness compared to ovariectomy and sham DEX groups. The consequent increase in remodeling activation increases the overall resorption rate without a compensatory increase in formation, leading to rapid bone loss.This negative effect on bone which is due to the glucocorticoid excess is also mediated by indirect mechanisms such as the calcium malabsorption and hypercalciuria. In response to the enhanced supply of calcium from the skeleton, PTH secretion tends to be diminished, thereby reducing vitamin D [1,25(OH)2 cholecalciferol] concentration with a consequent reduction in calcium absorption.
VL  - 3
IS  - 3
ER  -

Copy | Download