Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on diabetes and its related complication. Qualitative phytochemical analysis of C. longa and V. album were examined using standard procedures and the result revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, saponins, tannins, terpenoids and steroids respectively. Thirty six (36) male albino rats with the mean weight between 120-135g were divided into six (6) groups (n=6), group one (1) served as the normal control and there experimental groups were diabetic, induced with 150 mg/kg intraperitoneal alloxan injection. Body weight, blood sugar level, glycated hemoglobin, glucose-6-phosphate dehydrogenase, α-amylase, lipid profile, liver function and antioxidant markers were determined using standard procedures and the results revealed that, co-treatment with C. longa + V. album demonstrated an excellent weight reduction ability, hypoglycemic capacity, modulation of G6PDH, HBA1C and lipid profile, inhibition of α-amylase and enhancement of liver function and antioxidant levels. Therefore, co-treatment with C. longa + V. ablum can be a good therapeutic choice for the management of diabetes and its related conditions.
| Published in | International Journal of Diabetes and Endocrinology (Volume 4, Issue 1) |
| DOI | 10.11648/j.ijde.20190401.15 |
| Page(s) | 26-34 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Diabetes Mellitus, Curcuma Longa, Viscum Album, Lipid Profile, Liver Function and Antioxidant
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APA Style
Nwozo Sarah Onyenibe, Nyam Augustine Nathaniel, Nwawuba Stanley Udogadi, Olukotun Oluwakemi Iyanu. (2019). Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats. International Journal of Diabetes and Endocrinology, 4(1), 26-34. https://doi.org/10.11648/j.ijde.20190401.15
ACS Style
Nwozo Sarah Onyenibe; Nyam Augustine Nathaniel; Nwawuba Stanley Udogadi; Olukotun Oluwakemi Iyanu. Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats. Int. J. Diabetes Endocrinol. 2019, 4(1), 26-34. doi: 10.11648/j.ijde.20190401.15
AMA Style
Nwozo Sarah Onyenibe, Nyam Augustine Nathaniel, Nwawuba Stanley Udogadi, Olukotun Oluwakemi Iyanu. Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats. Int J Diabetes Endocrinol. 2019;4(1):26-34. doi: 10.11648/j.ijde.20190401.15
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Download@article{10.11648/j.ijde.20190401.15,
author = {Nwozo Sarah Onyenibe and Nyam Augustine Nathaniel and Nwawuba Stanley Udogadi and Olukotun Oluwakemi Iyanu},
title = {Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats},
journal = {International Journal of Diabetes and Endocrinology},
volume = {4},
number = {1},
pages = {26-34},
doi = {10.11648/j.ijde.20190401.15},
url = {https://doi.org/10.11648/j.ijde.20190401.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20190401.15},
abstract = {Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on diabetes and its related complication. Qualitative phytochemical analysis of C. longa and V. album were examined using standard procedures and the result revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, saponins, tannins, terpenoids and steroids respectively. Thirty six (36) male albino rats with the mean weight between 120-135g were divided into six (6) groups (n=6), group one (1) served as the normal control and there experimental groups were diabetic, induced with 150 mg/kg intraperitoneal alloxan injection. Body weight, blood sugar level, glycated hemoglobin, glucose-6-phosphate dehydrogenase, α-amylase, lipid profile, liver function and antioxidant markers were determined using standard procedures and the results revealed that, co-treatment with C. longa + V. album demonstrated an excellent weight reduction ability, hypoglycemic capacity, modulation of G6PDH, HBA1C and lipid profile, inhibition of α-amylase and enhancement of liver function and antioxidant levels. Therefore, co-treatment with C. longa + V. ablum can be a good therapeutic choice for the management of diabetes and its related conditions.},
year = {2019}
}
TY - JOUR T1 - Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats AU - Nwozo Sarah Onyenibe AU - Nyam Augustine Nathaniel AU - Nwawuba Stanley Udogadi AU - Olukotun Oluwakemi Iyanu Y1 - 2019/05/06 PY - 2019 N1 - https://doi.org/10.11648/j.ijde.20190401.15 DO - 10.11648/j.ijde.20190401.15 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 26 EP - 34 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20190401.15 AB - Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on diabetes and its related complication. Qualitative phytochemical analysis of C. longa and V. album were examined using standard procedures and the result revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, saponins, tannins, terpenoids and steroids respectively. Thirty six (36) male albino rats with the mean weight between 120-135g were divided into six (6) groups (n=6), group one (1) served as the normal control and there experimental groups were diabetic, induced with 150 mg/kg intraperitoneal alloxan injection. Body weight, blood sugar level, glycated hemoglobin, glucose-6-phosphate dehydrogenase, α-amylase, lipid profile, liver function and antioxidant markers were determined using standard procedures and the results revealed that, co-treatment with C. longa + V. album demonstrated an excellent weight reduction ability, hypoglycemic capacity, modulation of G6PDH, HBA1C and lipid profile, inhibition of α-amylase and enhancement of liver function and antioxidant levels. Therefore, co-treatment with C. longa + V. ablum can be a good therapeutic choice for the management of diabetes and its related conditions. VL - 4 IS - 1 ER -
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