Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes

Shradha Shrestha; Sharmin Jahan; Nusrat Sultana; Mohammad Fakhrul Alam; Yasmin Akter; Mohammad Farid Uddin; Muhammad Abul Hasanat

doi:doi:10.11648/j.ijde.20210602.11

Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes

Shradha Shrestha, Sharmin Jahan, Nusrat Sultana, Mohammad Fakhrul Alam, Yasmin Akter, Mohammad Farid Uddin, Muhammad Abul Hasanat

Published in International Journal of Diabetes and Endocrinology (Volume 6, Issue 2)

Received: 19 March 2021 Accepted: 12 April 2021 Published: 26 April 2021

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Abstract

Background: Increased plasma homocysteine levels are recognized to exert oxidative damage resulting into risk factors for insulin resistance (IR) and vascular disease. Present study was conducted to observe post-partum persistence of abnormal glucose tolerance (AGT) and level of homocysteine after delivery in patient with GDM. Methods: This observational cross-sectional study encompassed 100 subjects (age: 28.58±4.26 years, BMI: 26.7±2.80 Kg/m2; mean±SD) who were diagnosed as GDM during their index pregnancy by any of the internationally acceptable standard criteria. At 6-12 weeks post-partum, each of them underwent anthropometric measurements, 75 gram 2 sample OGTT and measurement of plasma homocysteine level by utilizing the chemiluminescent Immunoassay method. Results: Of the 100 subjects, 32% converted to having AGT during 6 – 12 week of post-partum follow up. Statistically significant difference was found in between the AGT and normal glucose tolerance (NGT) groups in circulating concentration of homocysteine (AGT vs NGT: 9.19±1.15 vs. 6.29±1.31 mmol/L; p=<0.001). Mean age and BMI were significantly higher in the AGT group (p<0.05 for both). Independent association was found between each of the variables age, history of macrosomia and higher homocysteine level with AGT in multiple regression analysis. Conclusion: Our study identified persistence of AGT and elevation of homocysteine levels are more prominent in women with GDM in post-partum period.

Published in	International Journal of Diabetes and Endocrinology (Volume 6, Issue 2)
DOI	10.11648/j.ijde.20210602.11
Page(s)	58-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

GDM, Plasma Homocysteine Level, Abnormal Glucose Tolerance

References

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[2]	Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA. 1997; 277: 1775–1781.
[3]	Cho NH, Lim S, Jang HC, et al. Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women With a Previous History of Gestational Diabetes Mellitus: A 4-year prospective study. Diabetes Care 2005; 28: 2750–2755.
[4]	Yang L, Zhang H, Jiang C, et al. Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue. J Bio Chem. 2013; 10: 1-23.
[5]	Meigs JB, Jacques PF, Selhub J, et al. Fasting Plasma Homocysteine Levels in the Insulin Resistance Syndrome: The Framingham Offspring Study. Diabetes Care 2001; 24: 1403–1410.
[6]	Hoffman L, Nolan C, Dennis Wilson J, et al. Gestational diabetes mellitus - management guidelines: The Australasian Diabetes in Pregnancy Society. Medical Journal of Australia 1998; 169: 93–97.
[7]	Metzger BE, Buchanan TA, Coustan DR, et al. Summary and Recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 2007; 30: S251–S260.
[8]	Chatterjee S. Pathogenesis of gestational diabetes mellitus. In: V Seshiah editor. Contemporary topics in gestational diabetes mellitus, 1^st edition, New Delhi: Jaypee Brothers; 2015, p. 18-23.
[9]	Shovierova H, Vidomanova E, Mahmood S, et al. The molecular and cellular effect of homocystein metabolism imbalance in human health. Int J Mol Sci 2016; 17 (10): 1733.
[10]	Sharmin-Jahan, Fariduddin M, Nusrat-Sultana, et al. Frequency of Post-partum Persistence of Glucose Intolerance in GDM Patients is Strikingly High at a Tertiary Care Hospital in Bangladesh. JCD 2015; 2 (2): 31-35.
[11]	Aktar Y, Hasanat MA, Jahan S, et al. Pregnancy Outcome in Gestational Diabetes Mellitus Under Treatment. Journal of Bioinformatics and Diabetes 2017; 1: 28–34.
[12]	Norhayati MN, Hazlina NHH, Asrenee AR, Wan-Emilin WMA. Magnitude and risk factors for postpartum symptoms: A literature review. Journal of Affective Disorder 2015; 175 (1): 34-52.
[13]	Tobias DK, Hu FB, Forman JP, et al. Increased Risk of Hypertension after Gestational Diabetes Mellitus: Findings from a large prospective cohort study. Diabetes Care 2011; 34: 1582–1584.
[14]	Jahan S, Fariduddin M, Sultana N, et al. Predictors of Post-Partum Persistence of Glucose Intolerance and Its Association with Cardio-Metabolic Risk Factors in Gestational Diabetes Mellitus. J Diabetes Metab 2015; 6: 609.
[15]	Nam, H. C, Lim, S, Hak, C, et al. Elevated Homocysteine as a Risk Factor for the Development of Diabetes in Women with a Previous History of Gestational Diabetes Mellitus. Diabetes Care 2005; 28: 2750-2755.

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APA Style

Shradha Shrestha, Sharmin Jahan, Nusrat Sultana, Mohammad Fakhrul Alam, Yasmin Akter, et al. (2021). Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. International Journal of Diabetes and Endocrinology, 6(2), 58-63. https://doi.org/10.11648/j.ijde.20210602.11

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ACS Style

Shradha Shrestha; Sharmin Jahan; Nusrat Sultana; Mohammad Fakhrul Alam; Yasmin Akter, et al. Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. Int. J. Diabetes Endocrinol. 2021, 6(2), 58-63. doi: 10.11648/j.ijde.20210602.11

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AMA Style

Shradha Shrestha, Sharmin Jahan, Nusrat Sultana, Mohammad Fakhrul Alam, Yasmin Akter, et al. Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. Int J Diabetes Endocrinol. 2021;6(2):58-63. doi: 10.11648/j.ijde.20210602.11

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@article{10.11648/j.ijde.20210602.11,
  author = {Shradha Shrestha and Sharmin Jahan and Nusrat Sultana and Mohammad Fakhrul Alam and Yasmin Akter and Mohammad Farid Uddin and Muhammad Abul Hasanat},
  title = {Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {2},
  pages = {58-63},
  doi = {10.11648/j.ijde.20210602.11},
  url = {https://doi.org/10.11648/j.ijde.20210602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210602.11},
  abstract = {Background: Increased plasma homocysteine levels are recognized to exert oxidative damage resulting into risk factors for insulin resistance (IR) and vascular disease. Present study was conducted to observe post-partum persistence of abnormal glucose tolerance (AGT) and level of homocysteine after delivery in patient with GDM. Methods: This observational cross-sectional study encompassed 100 subjects (age: 28.58±4.26 years, BMI: 26.7±2.80 Kg/m2; mean±SD) who were diagnosed as GDM during their index pregnancy by any of the internationally acceptable standard criteria. At 6-12 weeks post-partum, each of them underwent anthropometric measurements, 75 gram 2 sample OGTT and measurement of plasma homocysteine level by utilizing the chemiluminescent Immunoassay method. Results: Of the 100 subjects, 32% converted to having AGT during 6 – 12 week of post-partum follow up. Statistically significant difference was found in between the AGT and normal glucose tolerance (NGT) groups in circulating concentration of homocysteine (AGT vs NGT: 9.19±1.15 vs. 6.29±1.31 mmol/L; p=<0.001). Mean age and BMI were significantly higher in the AGT group (p<0.05 for both). Independent association was found between each of the variables age, history of macrosomia and higher homocysteine level with AGT in multiple regression analysis. Conclusion: Our study identified persistence of AGT and elevation of homocysteine levels are more prominent in women with GDM in post-partum period.},
 year = {2021}
}

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TY  - JOUR
T1  - Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes
AU  - Shradha Shrestha
AU  - Sharmin Jahan
AU  - Nusrat Sultana
AU  - Mohammad Fakhrul Alam
AU  - Yasmin Akter
AU  - Mohammad Farid Uddin
AU  - Muhammad Abul Hasanat
Y1  - 2021/04/26
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210602.11
DO  - 10.11648/j.ijde.20210602.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 58
EP  - 63
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210602.11
AB  - Background: Increased plasma homocysteine levels are recognized to exert oxidative damage resulting into risk factors for insulin resistance (IR) and vascular disease. Present study was conducted to observe post-partum persistence of abnormal glucose tolerance (AGT) and level of homocysteine after delivery in patient with GDM. Methods: This observational cross-sectional study encompassed 100 subjects (age: 28.58±4.26 years, BMI: 26.7±2.80 Kg/m2; mean±SD) who were diagnosed as GDM during their index pregnancy by any of the internationally acceptable standard criteria. At 6-12 weeks post-partum, each of them underwent anthropometric measurements, 75 gram 2 sample OGTT and measurement of plasma homocysteine level by utilizing the chemiluminescent Immunoassay method. Results: Of the 100 subjects, 32% converted to having AGT during 6 – 12 week of post-partum follow up. Statistically significant difference was found in between the AGT and normal glucose tolerance (NGT) groups in circulating concentration of homocysteine (AGT vs NGT: 9.19±1.15 vs. 6.29±1.31 mmol/L; p=<0.001). Mean age and BMI were significantly higher in the AGT group (p<0.05 for both). Independent association was found between each of the variables age, history of macrosomia and higher homocysteine level with AGT in multiple regression analysis. Conclusion: Our study identified persistence of AGT and elevation of homocysteine levels are more prominent in women with GDM in post-partum period.
VL  - 6
IS  - 2
ER  -

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Author Information

Shradha Shrestha

Department of Endocrinology, Vayodha Hospital, Balkhu, Kathmandu, Nepal
Sharmin Jahan

Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Nusrat Sultana

Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Fakhrul Alam

Department of Endocrinology, Abdul Malek Ukil Medical College, Noakhali, Bangladesh
Yasmin Akter

Department of Endocrinology, Bangladesh Medical College, Dhaka, Bangladesh
Mohammad Farid Uddin

Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Muhammad Abul Hasanat

Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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APA Style

Shradha Shrestha, Sharmin Jahan, Nusrat Sultana, Mohammad Fakhrul Alam, Yasmin Akter, et al. (2021). Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. International Journal of Diabetes and Endocrinology, 6(2), 58-63. https://doi.org/10.11648/j.ijde.20210602.11

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ACS Style

Shradha Shrestha; Sharmin Jahan; Nusrat Sultana; Mohammad Fakhrul Alam; Yasmin Akter, et al. Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. Int. J. Diabetes Endocrinol. 2021, 6(2), 58-63. doi: 10.11648/j.ijde.20210602.11

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AMA Style

Shradha Shrestha, Sharmin Jahan, Nusrat Sultana, Mohammad Fakhrul Alam, Yasmin Akter, et al. Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes. Int J Diabetes Endocrinol. 2021;6(2):58-63. doi: 10.11648/j.ijde.20210602.11

Copy | Download

@article{10.11648/j.ijde.20210602.11,
  author = {Shradha Shrestha and Sharmin Jahan and Nusrat Sultana and Mohammad Fakhrul Alam and Yasmin Akter and Mohammad Farid Uddin and Muhammad Abul Hasanat},
  title = {Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {2},
  pages = {58-63},
  doi = {10.11648/j.ijde.20210602.11},
  url = {https://doi.org/10.11648/j.ijde.20210602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210602.11},
  abstract = {Background: Increased plasma homocysteine levels are recognized to exert oxidative damage resulting into risk factors for insulin resistance (IR) and vascular disease. Present study was conducted to observe post-partum persistence of abnormal glucose tolerance (AGT) and level of homocysteine after delivery in patient with GDM. Methods: This observational cross-sectional study encompassed 100 subjects (age: 28.58±4.26 years, BMI: 26.7±2.80 Kg/m2; mean±SD) who were diagnosed as GDM during their index pregnancy by any of the internationally acceptable standard criteria. At 6-12 weeks post-partum, each of them underwent anthropometric measurements, 75 gram 2 sample OGTT and measurement of plasma homocysteine level by utilizing the chemiluminescent Immunoassay method. Results: Of the 100 subjects, 32% converted to having AGT during 6 – 12 week of post-partum follow up. Statistically significant difference was found in between the AGT and normal glucose tolerance (NGT) groups in circulating concentration of homocysteine (AGT vs NGT: 9.19±1.15 vs. 6.29±1.31 mmol/L; p=<0.001). Mean age and BMI were significantly higher in the AGT group (p<0.05 for both). Independent association was found between each of the variables age, history of macrosomia and higher homocysteine level with AGT in multiple regression analysis. Conclusion: Our study identified persistence of AGT and elevation of homocysteine levels are more prominent in women with GDM in post-partum period.},
 year = {2021}
}

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TY  - JOUR
T1  - Serum Homocysteine Level Might Be a Predictor for Persistence of Abnormal Glucose Tolerance in Gestational Diabetes
AU  - Shradha Shrestha
AU  - Sharmin Jahan
AU  - Nusrat Sultana
AU  - Mohammad Fakhrul Alam
AU  - Yasmin Akter
AU  - Mohammad Farid Uddin
AU  - Muhammad Abul Hasanat
Y1  - 2021/04/26
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210602.11
DO  - 10.11648/j.ijde.20210602.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 58
EP  - 63
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210602.11
AB  - Background: Increased plasma homocysteine levels are recognized to exert oxidative damage resulting into risk factors for insulin resistance (IR) and vascular disease. Present study was conducted to observe post-partum persistence of abnormal glucose tolerance (AGT) and level of homocysteine after delivery in patient with GDM. Methods: This observational cross-sectional study encompassed 100 subjects (age: 28.58±4.26 years, BMI: 26.7±2.80 Kg/m2; mean±SD) who were diagnosed as GDM during their index pregnancy by any of the internationally acceptable standard criteria. At 6-12 weeks post-partum, each of them underwent anthropometric measurements, 75 gram 2 sample OGTT and measurement of plasma homocysteine level by utilizing the chemiluminescent Immunoassay method. Results: Of the 100 subjects, 32% converted to having AGT during 6 – 12 week of post-partum follow up. Statistically significant difference was found in between the AGT and normal glucose tolerance (NGT) groups in circulating concentration of homocysteine (AGT vs NGT: 9.19±1.15 vs. 6.29±1.31 mmol/L; p=<0.001). Mean age and BMI were significantly higher in the AGT group (p<0.05 for both). Independent association was found between each of the variables age, history of macrosomia and higher homocysteine level with AGT in multiple regression analysis. Conclusion: Our study identified persistence of AGT and elevation of homocysteine levels are more prominent in women with GDM in post-partum period.
VL  - 6
IS  - 2
ER  -

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