Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome

Nazma Akter; Zafar Ahmed Latif

doi:doi:10.11648/j.ijde.20210602.15

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Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome

Nazma Akter, Zafar Ahmed Latif

Published in International Journal of Diabetes and Endocrinology (Volume 6, Issue 2)

Received: 10 May 2021 Accepted: 4 June 2021 Published: 16 June 2021

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Abstract

Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT4<0.71 ng/dL. Results: Among study population 22.8% were males and 77.2% were females, with mean age of 42.61±9.13 years. Average body mass index (BMI) of the study subjects was 26.37±3.78 kg/m². Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).

Published in	International Journal of Diabetes and Endocrinology (Volume 6, Issue 2)
DOI	10.11648/j.ijde.20210602.15
Page(s)	80-87
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Metabolic Syndrome, Thyroid Dysfunction, Subclinical Hypothyroidism, Hypothyroidism

References

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APA Style

Nazma Akter, Zafar Ahmed Latif. (2021). Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. International Journal of Diabetes and Endocrinology, 6(2), 80-87. https://doi.org/10.11648/j.ijde.20210602.15

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ACS Style

Nazma Akter; Zafar Ahmed Latif. Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. Int. J. Diabetes Endocrinol. 2021, 6(2), 80-87. doi: 10.11648/j.ijde.20210602.15

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AMA Style

Nazma Akter, Zafar Ahmed Latif. Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. Int J Diabetes Endocrinol. 2021;6(2):80-87. doi: 10.11648/j.ijde.20210602.15

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@article{10.11648/j.ijde.20210602.15,
  author = {Nazma Akter and Zafar Ahmed Latif},
  title = {Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {2},
  pages = {80-87},
  doi = {10.11648/j.ijde.20210602.15},
  url = {https://doi.org/10.11648/j.ijde.20210602.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210602.15},
  abstract = {Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT42. Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).},
 year = {2021}
}

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TY  - JOUR
T1  - Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome
AU  - Nazma Akter
AU  - Zafar Ahmed Latif
Y1  - 2021/06/16
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210602.15
DO  - 10.11648/j.ijde.20210602.15
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 80
EP  - 87
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210602.15
AB  - Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT42. Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).
VL  - 6
IS  - 2
ER  -

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Author Information

Nazma Akter

Department of Medicine, MARKS Medical College & Hospital, Dhaka, Bangladesh
Zafar Ahmed Latif

BIRDEM General Hospital, Dhaka, Bangladesh

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APA Style

Nazma Akter, Zafar Ahmed Latif. (2021). Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. International Journal of Diabetes and Endocrinology, 6(2), 80-87. https://doi.org/10.11648/j.ijde.20210602.15

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ACS Style

Nazma Akter; Zafar Ahmed Latif. Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. Int. J. Diabetes Endocrinol. 2021, 6(2), 80-87. doi: 10.11648/j.ijde.20210602.15

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AMA Style

Nazma Akter, Zafar Ahmed Latif. Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome. Int J Diabetes Endocrinol. 2021;6(2):80-87. doi: 10.11648/j.ijde.20210602.15

Copy | Download

@article{10.11648/j.ijde.20210602.15,
  author = {Nazma Akter and Zafar Ahmed Latif},
  title = {Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {6},
  number = {2},
  pages = {80-87},
  doi = {10.11648/j.ijde.20210602.15},
  url = {https://doi.org/10.11648/j.ijde.20210602.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210602.15},
  abstract = {Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT42. Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome
AU  - Nazma Akter
AU  - Zafar Ahmed Latif
Y1  - 2021/06/16
PY  - 2021
N1  - https://doi.org/10.11648/j.ijde.20210602.15
DO  - 10.11648/j.ijde.20210602.15
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 80
EP  - 87
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20210602.15
AB  - Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT42. Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).
VL  - 6
IS  - 2
ER  -

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