Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia

Diana Shintawati Purwanto; Yanti Meilen Mewo; Stefana Helena Margaretha Kaligis; Edmond Leonard Jim

doi:doi:10.11648/j.ijde.20220704.11

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Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia

Diana Shintawati Purwanto, Yanti Meilen Mewo, Stefana Helena Margaretha Kaligis, Edmond Leonard Jim

Published in International Journal of Diabetes and Endocrinology (Volume 7, Issue 4)

Received: 22 September 2022 Accepted: 10 October 2022 Published: 18 October 2022

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Abstract

Diabetes mellitus is still an important health problem in Indonesia because the incidence is increasing every year and most patients do not achieve good and proper glycemic control. Analysis of blood ferritin levels in type 2 diabetes mellitus patients is considered limited in many areas. As a marker of iron stores in the body, elevated serum ferritin has been associated with microvascular and macrovascular complications of diabetes mellitus. This study aimed to determine the correlation between serum ferritin levels and fasting blood glucose, glycated hemoglobin (HbA1c), and other biochemical parameters in type 2 diabetes mellitus patients in North Sulawesi, Indonesia. A total of 108 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, hemoglobin, glycated hemoglobin (HbA1c), ferritin, urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, cholesterol, and triglyceride. The averages of HbA1c% in the good, moderate, and poor groups were 5.70 ± 0.5%, 7.2 ± 0.6, and 10.1 ± 1.6, respectively. Increased fasting blood glucose, ferritin, urea, creatinine, and uric acid levels were observed along with worsening glycemic status. There were significant correlations between serum ferritin and fasting blood glucose, glycated hemoglobin, and alanine aminotransferase (p < 0.05). There were significantly different mean ferritin values in the three groups of glycated hemoglobin, suggesting ferritin can be used as an indicator of control of glycemia and diabetic complications.

Published in	International Journal of Diabetes and Endocrinology (Volume 7, Issue 4)
DOI	10.11648/j.ijde.20220704.11
Page(s)	103-108
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Ferritin, Glycated Hemoglobin, HbA1c, Blood Glucose

References

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APA Style

Diana Shintawati Purwanto, Yanti Meilen Mewo, Stefana Helena Margaretha Kaligis, Edmond Leonard Jim. (2022). Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. International Journal of Diabetes and Endocrinology, 7(4), 103-108. https://doi.org/10.11648/j.ijde.20220704.11

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ACS Style

Diana Shintawati Purwanto; Yanti Meilen Mewo; Stefana Helena Margaretha Kaligis; Edmond Leonard Jim. Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. Int. J. Diabetes Endocrinol. 2022, 7(4), 103-108. doi: 10.11648/j.ijde.20220704.11

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AMA Style

Diana Shintawati Purwanto, Yanti Meilen Mewo, Stefana Helena Margaretha Kaligis, Edmond Leonard Jim. Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. Int J Diabetes Endocrinol. 2022;7(4):103-108. doi: 10.11648/j.ijde.20220704.11

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@article{10.11648/j.ijde.20220704.11,
  author = {Diana Shintawati Purwanto and Yanti Meilen Mewo and Stefana Helena Margaretha Kaligis and Edmond Leonard Jim},
  title = {Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {7},
  number = {4},
  pages = {103-108},
  doi = {10.11648/j.ijde.20220704.11},
  url = {https://doi.org/10.11648/j.ijde.20220704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220704.11},
  abstract = {Diabetes mellitus is still an important health problem in Indonesia because the incidence is increasing every year and most patients do not achieve good and proper glycemic control. Analysis of blood ferritin levels in type 2 diabetes mellitus patients is considered limited in many areas. As a marker of iron stores in the body, elevated serum ferritin has been associated with microvascular and macrovascular complications of diabetes mellitus. This study aimed to determine the correlation between serum ferritin levels and fasting blood glucose, glycated hemoglobin (HbA1c), and other biochemical parameters in type 2 diabetes mellitus patients in North Sulawesi, Indonesia. A total of 108 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, hemoglobin, glycated hemoglobin (HbA1c), ferritin, urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, cholesterol, and triglyceride. The averages of HbA1c% in the good, moderate, and poor groups were 5.70 ± 0.5%, 7.2 ± 0.6, and 10.1 ± 1.6, respectively. Increased fasting blood glucose, ferritin, urea, creatinine, and uric acid levels were observed along with worsening glycemic status. There were significant correlations between serum ferritin and fasting blood glucose, glycated hemoglobin, and alanine aminotransferase (p < 0.05). There were significantly different mean ferritin values in the three groups of glycated hemoglobin, suggesting ferritin can be used as an indicator of control of glycemia and diabetic complications.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia
AU  - Diana Shintawati Purwanto
AU  - Yanti Meilen Mewo
AU  - Stefana Helena Margaretha Kaligis
AU  - Edmond Leonard Jim
Y1  - 2022/10/18
PY  - 2022
N1  - https://doi.org/10.11648/j.ijde.20220704.11
DO  - 10.11648/j.ijde.20220704.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 103
EP  - 108
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20220704.11
AB  - Diabetes mellitus is still an important health problem in Indonesia because the incidence is increasing every year and most patients do not achieve good and proper glycemic control. Analysis of blood ferritin levels in type 2 diabetes mellitus patients is considered limited in many areas. As a marker of iron stores in the body, elevated serum ferritin has been associated with microvascular and macrovascular complications of diabetes mellitus. This study aimed to determine the correlation between serum ferritin levels and fasting blood glucose, glycated hemoglobin (HbA1c), and other biochemical parameters in type 2 diabetes mellitus patients in North Sulawesi, Indonesia. A total of 108 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, hemoglobin, glycated hemoglobin (HbA1c), ferritin, urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, cholesterol, and triglyceride. The averages of HbA1c% in the good, moderate, and poor groups were 5.70 ± 0.5%, 7.2 ± 0.6, and 10.1 ± 1.6, respectively. Increased fasting blood glucose, ferritin, urea, creatinine, and uric acid levels were observed along with worsening glycemic status. There were significant correlations between serum ferritin and fasting blood glucose, glycated hemoglobin, and alanine aminotransferase (p < 0.05). There were significantly different mean ferritin values in the three groups of glycated hemoglobin, suggesting ferritin can be used as an indicator of control of glycemia and diabetic complications.
VL  - 7
IS  - 4
ER  -

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Author Information

Diana Shintawati Purwanto

Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
Yanti Meilen Mewo

Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
Stefana Helena Margaretha Kaligis

Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
Edmond Leonard Jim

Department of Cardiovascular Medicine, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

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APA Style

Diana Shintawati Purwanto, Yanti Meilen Mewo, Stefana Helena Margaretha Kaligis, Edmond Leonard Jim. (2022). Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. International Journal of Diabetes and Endocrinology, 7(4), 103-108. https://doi.org/10.11648/j.ijde.20220704.11

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ACS Style

Diana Shintawati Purwanto; Yanti Meilen Mewo; Stefana Helena Margaretha Kaligis; Edmond Leonard Jim. Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. Int. J. Diabetes Endocrinol. 2022, 7(4), 103-108. doi: 10.11648/j.ijde.20220704.11

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AMA Style

Diana Shintawati Purwanto, Yanti Meilen Mewo, Stefana Helena Margaretha Kaligis, Edmond Leonard Jim. Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia. Int J Diabetes Endocrinol. 2022;7(4):103-108. doi: 10.11648/j.ijde.20220704.11

Copy | Download

@article{10.11648/j.ijde.20220704.11,
  author = {Diana Shintawati Purwanto and Yanti Meilen Mewo and Stefana Helena Margaretha Kaligis and Edmond Leonard Jim},
  title = {Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {7},
  number = {4},
  pages = {103-108},
  doi = {10.11648/j.ijde.20220704.11},
  url = {https://doi.org/10.11648/j.ijde.20220704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220704.11},
  abstract = {Diabetes mellitus is still an important health problem in Indonesia because the incidence is increasing every year and most patients do not achieve good and proper glycemic control. Analysis of blood ferritin levels in type 2 diabetes mellitus patients is considered limited in many areas. As a marker of iron stores in the body, elevated serum ferritin has been associated with microvascular and macrovascular complications of diabetes mellitus. This study aimed to determine the correlation between serum ferritin levels and fasting blood glucose, glycated hemoglobin (HbA1c), and other biochemical parameters in type 2 diabetes mellitus patients in North Sulawesi, Indonesia. A total of 108 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, hemoglobin, glycated hemoglobin (HbA1c), ferritin, urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, cholesterol, and triglyceride. The averages of HbA1c% in the good, moderate, and poor groups were 5.70 ± 0.5%, 7.2 ± 0.6, and 10.1 ± 1.6, respectively. Increased fasting blood glucose, ferritin, urea, creatinine, and uric acid levels were observed along with worsening glycemic status. There were significant correlations between serum ferritin and fasting blood glucose, glycated hemoglobin, and alanine aminotransferase (p < 0.05). There were significantly different mean ferritin values in the three groups of glycated hemoglobin, suggesting ferritin can be used as an indicator of control of glycemia and diabetic complications.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of Serum Ferritin in Type 2 Diabetes Mellitus: An Observational Study from North Sulawesi, Indonesia
AU  - Diana Shintawati Purwanto
AU  - Yanti Meilen Mewo
AU  - Stefana Helena Margaretha Kaligis
AU  - Edmond Leonard Jim
Y1  - 2022/10/18
PY  - 2022
N1  - https://doi.org/10.11648/j.ijde.20220704.11
DO  - 10.11648/j.ijde.20220704.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 103
EP  - 108
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20220704.11
AB  - Diabetes mellitus is still an important health problem in Indonesia because the incidence is increasing every year and most patients do not achieve good and proper glycemic control. Analysis of blood ferritin levels in type 2 diabetes mellitus patients is considered limited in many areas. As a marker of iron stores in the body, elevated serum ferritin has been associated with microvascular and macrovascular complications of diabetes mellitus. This study aimed to determine the correlation between serum ferritin levels and fasting blood glucose, glycated hemoglobin (HbA1c), and other biochemical parameters in type 2 diabetes mellitus patients in North Sulawesi, Indonesia. A total of 108 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, hemoglobin, glycated hemoglobin (HbA1c), ferritin, urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, cholesterol, and triglyceride. The averages of HbA1c% in the good, moderate, and poor groups were 5.70 ± 0.5%, 7.2 ± 0.6, and 10.1 ± 1.6, respectively. Increased fasting blood glucose, ferritin, urea, creatinine, and uric acid levels were observed along with worsening glycemic status. There were significant correlations between serum ferritin and fasting blood glucose, glycated hemoglobin, and alanine aminotransferase (p < 0.05). There were significantly different mean ferritin values in the three groups of glycated hemoglobin, suggesting ferritin can be used as an indicator of control of glycemia and diabetic complications.
VL  - 7
IS  - 4
ER  -

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