Prevalence of Multidrug Resistant (MDR) <i>Proteus</i> spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi

Anika Tasnim; Md. Shah Alam; Md. Abdullah Yusuf; Fazlay Akbar Khan; Jannatul Ferdose; Mahmuda Sultana

doi:doi:10.11648/j.ijidt.20210602.14

| Peer-Reviewed

Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi

Anika Tasnim, Md. Shah Alam, Md. Abdullah Yusuf, Fazlay Akbar Khan, Jannatul Ferdose, Mahmuda Sultana

Published in International Journal of Infectious Diseases and Therapy (Volume 6, Issue 2)

Received: 29 April 2021 Accepted: 27 May 2021 Published: 4 June 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: Multidrug resistant (MDR) bacteria are an emerging public health issue in all over the world especially in developing countries like Bangladesh. Objective: This study was aimed to determine the prevalence of MDR Proteus species in burn wound infected patients admitted in Burn and Plastic Surgery Unit, Rajshahi Medical College Hospital (RMCH). Methodology: This cross sectional study was conducted at Microbiology Department of Rajshahi Medical College, Rajshahi, Bangladesh. A total of 212 wound swabs were collected and processed as per standard protocol from January to December 2016 for a period of one year. The isolation and identification of Proteus species was done by conventional microbiological process and antimicrobial susceptibility was performed by Modified Kirby-Bauer disk diffusion method. The Proteus species was further classified into MDR on the basis of standardised international criteria. Result: Among the 196 isolates from 212 wound swabs, Proteus spp. was the 2^nd most frequent isolated organism (23.47%) following Pseudomonas aeruginosa (34.18%). Two species of Proteus were identified; Proteus mirabilis (65.22%) and Proteus vulgaris (34.78%). More than 75.0% Proteus spp. showed resistance to ciprofloxacin and ceftriaxone where meropenem was the highest sensitive drug (>93%). MDR Proteus spp. were 63.04% among which Proteus mirabilis and Proteus vulgaris were 60% & 68.75% MDR respectively. Conclusion: This study culminates the high prevalence of MDR Proteus spp. in Burn Unit of RMCH and decreased sensitivity to commonly used antibiotics. Therefore a greater emphasis on prevention of MDR bacterial colonization and antibiotic stewardship are imperative.

Published in	International Journal of Infectious Diseases and Therapy (Volume 6, Issue 2)
DOI	10.11648/j.ijidt.20210602.14
Page(s)	65-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Burn Wound Infection, Multidrug Resistant (MDR), Proteus spp.

References

[1]	Melake NA, Eissaa NA, Keshkb TF, Sleem AS. (2015). Prevalence of multidrug- resistant bacteria isolated from patients with burn infection. Menoufia Medical Journal. 28: 677–684.
[2]	Alam MM, Islam MN, Hawlader MDH, Ahmed S, Wahab A, Islam M, KM Roshed Uddin KMR, Hossain A. (2020). Prevalence of multidrug resistance bacterial isolates from infected wound patients in Dhaka, Bangladesh: A cross-sectional study. International Journal of Surgery Open. 28 (2021): 56-62.
[3]	Al-Bassam WW, Al-Kazaz AK. (2013). The Isolation and Characterization of Proteus mirabilis from Different Clinical Samples. Journal of Biotechnology Research Center. 7 (2): 24-30.
[4]	Mordi RM, Momoh MI. (2009). Incidence of Proteus species in wound infections and their sensitivity pattern in the University of Benin Teaching Hospital. African Journal of Biotechnology. 8 (5): 725-730.
[5]	Abbas HA, El-Saysed MA, Ganiny AM, Fattah AA. (2018). Antimicrobial Resistance Patterns of Proteus mirabilis isolates from Urinary tract, burn wound and Diabetic foot Infections. Research Journal of Pharmacy and Technology. 11 (1): 249-252.
[6]	Gallaher JR, Banda W, Lachiewicz AM, Krysiak R, Cairns BA, Charles AG. (2018). Colonization with Multidrug Resistant Enterobacteriaceae is Associated with Increased Mortality Following Burn Injury in Sub-Saharan Africa. World J Surg. 42 (10): 3089–3096.
[7]	Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG et al. (2012). Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect Dis. 18: 268-281
[8]	Pal N, Sharma N, Sharma R, Hooja S, Maheshwari RK. (2014). Prevalence of Multidrug (MDR) and Extensively Drug Resistant (XDR) Proteus species in a tertiary care hospital, India. Int. J. Curr. Microbiol. App. Sci. 3 (10): 243-252.
[9]	CLSI. (2015). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational Supplement.
[10]	Alam SMS, Kalam MAK, Munna MS, Munshi SK, Noor R. (2014). Isolation of pathogenic microorganisms from burn patients admitted in Dhaka Medical College and Hospital and demonstration of their drug-resistance traits. Asian pacific Journal of Tropical Disease. 4 (5): 402-407
[11]	Saha SK, Muazzam N, Begum SA, Chowdhury A, Islam MS, Parveen R. (2011). Study on Time-related Changes in Aerobic Bacterial Pattern of Burn Wound Infection. Faridpur Med Coll J. 6 (1): 41-45.
[12]	Begum H, Quamruzzaman M, Talukdar M. (2011). Microbial Isolates from Patients and their Antibiogram at the Tertiary care Burn Unit in Bangladesh. J Bangladesh CollPhys Surg. 29: 62-66.
[13]	Lakshmi N, Koripella R, Manem J, Krishna PB. (2015). Bacteriological profile and Antibiogram of Burn wound infections in a tertiary care hospital. IOSR Journal of Dental and Medical Sciences. 14 (10): 1-4.
[14]	Mehta M, Dutta P, Gupta V. (2007). Bacterial isolates from burn wound infections and their antibiograms: A eight-year study. Indian Journal of Plastic Surgery. 40 (1): 25-28.
[15]	Perween N, Prakash SK, Bharara T. (2016). Prevalence of Multidrug-Resistant and Extensively Drug-Resistant Proteus, Providencia and Morganella Species in Burn Wound Infection. International Journal of Scientific Study. 3 (11): 154-156.
[16]	Feglo PK, Gbedema SY, Quay SNA, Adu-Sarkodie Y, Opoku-Okrah C. (2010). Occurance, species distribution and case study at the Komfo Anokye Teaching Hospital (KATH) in Ghana. International Journal of Pharma Sciences and Research (IJPSR). 1 (9): 347-352.
[17]	Pandey JK, Narayan A, Tyagi S. (2013). Prevalence of Proteus species in clinical samples, antibiotic sensitivity pattern and ESBL production. International Journal of Current Microbiology and Applied Sciences. 2 (10): 253-261.
[18]	Rao SR, Lakshmi LJ, Pavani S, Kawle V, Prakash SJ. (2014). Bacteriological profile, antibiogram of burn wound isolates and detection of MRSA and ESBL production at tertiary care hospital, Hyderabad. World Journal of Pharmacy and Pharmaceutical Sciences. 3 (10): 1691-1698.
[19]	Rajbahak S, Shrestha C, Shrestha J, Singh A. (2014). Bacteriological changes of burn wounds with time and their antibiogram. Scientific World. 12 (12): 70-76.

Cite This Article

Plain Text BibTeX RIS

APA Style

Anika Tasnim, Md. Shah Alam, Md. Abdullah Yusuf, Fazlay Akbar Khan, Jannatul Ferdose, et al. (2021). Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. International Journal of Infectious Diseases and Therapy, 6(2), 65-68. https://doi.org/10.11648/j.ijidt.20210602.14

Copy | Download

ACS Style

Anika Tasnim; Md. Shah Alam; Md. Abdullah Yusuf; Fazlay Akbar Khan; Jannatul Ferdose, et al. Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. Int. J. Infect. Dis. Ther. 2021, 6(2), 65-68. doi: 10.11648/j.ijidt.20210602.14

Copy | Download

AMA Style

Anika Tasnim, Md. Shah Alam, Md. Abdullah Yusuf, Fazlay Akbar Khan, Jannatul Ferdose, et al. Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. Int J Infect Dis Ther. 2021;6(2):65-68. doi: 10.11648/j.ijidt.20210602.14

Copy | Download

@article{10.11648/j.ijidt.20210602.14,
  author = {Anika Tasnim and Md. Shah Alam and Md. Abdullah Yusuf and Fazlay Akbar Khan and Jannatul Ferdose and Mahmuda Sultana},
  title = {Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {6},
  number = {2},
  pages = {65-68},
  doi = {10.11648/j.ijidt.20210602.14},
  url = {https://doi.org/10.11648/j.ijidt.20210602.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210602.14},
  abstract = {Background: Multidrug resistant (MDR) bacteria are an emerging public health issue in all over the world especially in developing countries like Bangladesh. Objective: This study was aimed to determine the prevalence of MDR Proteus species in burn wound infected patients admitted in Burn and Plastic Surgery Unit, Rajshahi Medical College Hospital (RMCH). Methodology: This cross sectional study was conducted at Microbiology Department of Rajshahi Medical College, Rajshahi, Bangladesh. A total of 212 wound swabs were collected and processed as per standard protocol from January to December 2016 for a period of one year. The isolation and identification of Proteus species was done by conventional microbiological process and antimicrobial susceptibility was performed by Modified Kirby-Bauer disk diffusion method. The Proteus species was further classified into MDR on the basis of standardised international criteria. Result: Among the 196 isolates from 212 wound swabs, Proteus spp. was the 2nd most frequent isolated organism (23.47%) following Pseudomonas aeruginosa (34.18%). Two species of Proteus were identified; Proteus mirabilis (65.22%) and Proteus vulgaris (34.78%). More than 75.0% Proteus spp. showed resistance to ciprofloxacin and ceftriaxone where meropenem was the highest sensitive drug (>93%). MDR Proteus spp. were 63.04% among which Proteus mirabilis and Proteus vulgaris were 60% & 68.75% MDR respectively. Conclusion: This study culminates the high prevalence of MDR Proteus spp. in Burn Unit of RMCH and decreased sensitivity to commonly used antibiotics. Therefore a greater emphasis on prevention of MDR bacterial colonization and antibiotic stewardship are imperative.},
 year = {2021}
}

Copy | Download

TY - JOUR
T1 - Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi
AU - Anika Tasnim
AU - Md. Shah Alam
AU - Md. Abdullah Yusuf
AU - Fazlay Akbar Khan
AU - Jannatul Ferdose
AU - Mahmuda Sultana
Y1 - 2021/06/04
PY - 2021
N1 - https://doi.org/10.11648/j.ijidt.20210602.14
DO - 10.11648/j.ijidt.20210602.14
T2 - International Journal of Infectious Diseases and Therapy
JF - International Journal of Infectious Diseases and Therapy
JO - International Journal of Infectious Diseases and Therapy
SP - 65
EP - 68
PB - Science Publishing Group
SN - 2578-966X
UR - https://doi.org/10.11648/j.ijidt.20210602.14
AB - Background: Multidrug resistant (MDR) bacteria are an emerging public health issue in all over the world especially in developing countries like Bangladesh. Objective: This study was aimed to determine the prevalence of MDR Proteus species in burn wound infected patients admitted in Burn and Plastic Surgery Unit, Rajshahi Medical College Hospital (RMCH). Methodology: This cross sectional study was conducted at Microbiology Department of Rajshahi Medical College, Rajshahi, Bangladesh. A total of 212 wound swabs were collected and processed as per standard protocol from January to December 2016 for a period of one year. The isolation and identification of Proteus species was done by conventional microbiological process and antimicrobial susceptibility was performed by Modified Kirby-Bauer disk diffusion method. The Proteus species was further classified into MDR on the basis of standardised international criteria. Result: Among the 196 isolates from 212 wound swabs, Proteus spp. was the 2nd most frequent isolated organism (23.47%) following Pseudomonas aeruginosa (34.18%). Two species of Proteus were identified; Proteus mirabilis (65.22%) and Proteus vulgaris (34.78%). More than 75.0% Proteus spp. showed resistance to ciprofloxacin and ceftriaxone where meropenem was the highest sensitive drug (>93%). MDR Proteus spp. were 63.04% among which Proteus mirabilis and Proteus vulgaris were 60% & 68.75% MDR respectively. Conclusion: This study culminates the high prevalence of MDR Proteus spp. in Burn Unit of RMCH and decreased sensitivity to commonly used antibiotics. Therefore a greater emphasis on prevention of MDR bacterial colonization and antibiotic stewardship are imperative.
VL - 6
IS - 2
ER -

Copy | Download

Author Information

Anika Tasnim

Department of Microbiology, Parkview Medical College, Sylhet, Bangladesh
Md. Shah Alam

Department of Microbiology, Rajshahi Medical College, Rajshahi, Bangladesh
Md. Abdullah Yusuf

Department of Microbiology, National Institute of Neurosciences and Hospital, Dhaka, Banglades
Fazlay Akbar Khan

Department of Orthopedic Surgery, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh
Jannatul Ferdose

Pathology and Microbiology Department, National Institute of Diseases of Chest and Hospital, Mohakhali, Dhaka, Bangladesh
Mahmuda Sultana

Department of Anatomy, Parkview Medical College, Sylhet, Bangladesh

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Anika Tasnim, Md. Shah Alam, Md. Abdullah Yusuf, Fazlay Akbar Khan, Jannatul Ferdose, et al. (2021). Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. International Journal of Infectious Diseases and Therapy, 6(2), 65-68. https://doi.org/10.11648/j.ijidt.20210602.14

Copy | Download

ACS Style

Anika Tasnim; Md. Shah Alam; Md. Abdullah Yusuf; Fazlay Akbar Khan; Jannatul Ferdose, et al. Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. Int. J. Infect. Dis. Ther. 2021, 6(2), 65-68. doi: 10.11648/j.ijidt.20210602.14

Copy | Download

AMA Style

Anika Tasnim, Md. Shah Alam, Md. Abdullah Yusuf, Fazlay Akbar Khan, Jannatul Ferdose, et al. Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi. Int J Infect Dis Ther. 2021;6(2):65-68. doi: 10.11648/j.ijidt.20210602.14

Copy | Download

@article{10.11648/j.ijidt.20210602.14,
  author = {Anika Tasnim and Md. Shah Alam and Md. Abdullah Yusuf and Fazlay Akbar Khan and Jannatul Ferdose and Mahmuda Sultana},
  title = {Prevalence of Multidrug Resistant (MDR) Proteus spp. in Burn Wound Infection of a Tertiary Care Hospital, Rajshahi},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {6},
  number = {2},
  pages = {65-68},
  doi = {10.11648/j.ijidt.20210602.14},
  url = {https://doi.org/10.11648/j.ijidt.20210602.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210602.14},
  abstract = {Background: Multidrug resistant (MDR) bacteria are an emerging public health issue in all over the world especially in developing countries like Bangladesh. Objective: This study was aimed to determine the prevalence of MDR Proteus species in burn wound infected patients admitted in Burn and Plastic Surgery Unit, Rajshahi Medical College Hospital (RMCH). Methodology: This cross sectional study was conducted at Microbiology Department of Rajshahi Medical College, Rajshahi, Bangladesh. A total of 212 wound swabs were collected and processed as per standard protocol from January to December 2016 for a period of one year. The isolation and identification of Proteus species was done by conventional microbiological process and antimicrobial susceptibility was performed by Modified Kirby-Bauer disk diffusion method. The Proteus species was further classified into MDR on the basis of standardised international criteria. Result: Among the 196 isolates from 212 wound swabs, Proteus spp. was the 2nd most frequent isolated organism (23.47%) following Pseudomonas aeruginosa (34.18%). Two species of Proteus were identified; Proteus mirabilis (65.22%) and Proteus vulgaris (34.78%). More than 75.0% Proteus spp. showed resistance to ciprofloxacin and ceftriaxone where meropenem was the highest sensitive drug (>93%). MDR Proteus spp. were 63.04% among which Proteus mirabilis and Proteus vulgaris were 60% & 68.75% MDR respectively. Conclusion: This study culminates the high prevalence of MDR Proteus spp. in Burn Unit of RMCH and decreased sensitivity to commonly used antibiotics. Therefore a greater emphasis on prevention of MDR bacterial colonization and antibiotic stewardship are imperative.},
 year = {2021}
}

Copy | Download