Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria

Laura Madukaji; Ebenezer Obi Daniel; Francis Ejeh; Adewole Olanisun Olufemi; Ahmed Mamuda Bello; Paul Olaiya Abiodun; Israel Olukayode Popoola; Kabir Yunusa Amari; Christiana Asibi Ogben; Michael Oladapo Olagbegi; Gabriel Omoniyi Ayeni; Olayinka Victor Ojo; John Danjuma Mawak

doi:doi:10.11648/j.ijidt.20210603.12

Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria

Laura Madukaji, Ebenezer Obi Daniel, Francis Ejeh, Adewole Olanisun Olufemi, Ahmed Mamuda Bello, Paul Olaiya Abiodun, Israel Olukayode Popoola, Kabir Yunusa Amari, Christiana Asibi Ogben, Michael Oladapo Olagbegi, Gabriel Omoniyi Ayeni, Olayinka Victor Ojo, John Danjuma Mawak

Published in International Journal of Infectious Diseases and Therapy (Volume 6, Issue 3)

Received: 19 July 2021 Accepted: 28 July 2021 Published: 4 August 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The efforts geared towards control of Tuberculosis is threatened by the spread of multidrug resistance. Severe forms of multidrug resistant TB termed Pre-extensive (Pre-XDR) and Extensively Drug resistant (XDR) TB have been reported by different countries including Indian, China, Russia and Nigeria. Previous studies have shown a strong association between these various forms of resistance and non-adherence. The study was conducted to identify the factors affecting adherence, assess level of adherence and the perception of care among Multidrug resistant clients in North Central Nigeria. Specific & structures Questionnaires were administered to 96 MDR TB patients and 67 healthcare providers (representing 50% of each of the professional group). Few patients and healthcare providers were later selected from the number that responded to questionnaires and were involved in Focus Group Discussion. Responses from participants showed that the factors affecting adherence were alcohol addiction (72.9%), lack of social support (88.5%), feeling cured (28.1%), access to treatment centre (46.9%), non-payment & inadequate incentives/enablers for patients to continue treatment (38.5%), Stigma and discrimination (31.3%), financial difficulty (25%), treatment side effect (39.6%) and long treatment course & high pill burden (55.2%). Patients’ level of satisfaction on care was high (66.7%) indicating a satisfactory perception. This study revealed that factors affecting non-adherence were multifactorial and patients’ perception on MDR TB care was satisfactory.

Published in	International Journal of Infectious Diseases and Therapy (Volume 6, Issue 3)
DOI	10.11648/j.ijidt.20210603.12
Page(s)	90-96
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Adherence, Perception of MDR TB Care, Multidrug Resistant Tuberculosis, North Central, Nigeria

References

[1]	Mekonnen, H. S., & Azagew, A. W. (2018). Non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers, Northwest Ethiopia. BMC research notes, 11 (1), 691. https://doi.org/10.1186/s13104-018-3789-4.
[2]	Mohammadi, E., Abedi, H. A., Gofranipour, E., Jalali, F & Kazemnejad, A. (2009). Evaluation of 'partnership care model' in the control of hypertension. International Journal of Nursing Practice, 12, 153-159.
[3]	Habteyes Hailu Tola, Azar Tol, Davoud Shojaeizadeh, Gholamreza Garmaroudi (2015). Tuberculosis Treatment Non-Adherence and Lost to Follow Up among TB Patients with or without HIV in Developing Countries: A Systematic Review. Iran J Public Health, Vol. 44, No. 1, pp. 1-11.
[4]	Gehre, F., Otu, J., Kendall, L. et al. (2016). The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance. BMC Med 14, 160. https://doi.org/10.1186/s12916-016-0704-5.
[5]	Sukartini, T., Minarni, I. and Asmoro, C. (2018). Family Support, Self-efficacy, Motivation, and Treatment Adherence in Multidrug-resistant Tuberculosis Patients. In Proceedings of the 9th International Nursing Conference. pages 178-182. DOI: 10.5220/0008322301780182. ISBN: 978-989-758-336-0.
[6]	Kalagari Sh, Yazdi K, Mir Karimi Z, Behnampour N (2008). Study of hospitalized patients' views about respecting to the human territory in the 5 Azar hospital in Gorgan Journal of Booie Nursing Faculty of Gorgan. 5: 27-31 [Google Scholar].
[7]	Kuzu A, Ergin A, Zencir M. (2006). Patients' awareness of their rights in a developing country. Public Health. 120: 290-6 [PubMed] [Google Scholar].
[8]	Khamis, K. and Njau, B. (2014) Patients’ level of satisfaction on quality of health care at Mwananyamala hospital in Dar es Salaam, Tanzania. BMC Health Serv Res 14, 400. https://doi.org/10.1186/1472-6963-14-400.
[9]	Leshabari M, Muhondwa P, Mwangu M, Mbembati A (2008). Motivation of health care workers in Tanzania; a case study of Muhimbili National Hospital. East Africa Journal of Public Health. 5: 1.
[10]	Macq JC, Theobald S, Dick J, Dembele M. (2003). An exploration of the concept of directly observed treatment (DOT) for tuberculosis patients: from a uniform to a customized approach. Int J Tuberc Lung Dis. 7 (2): 103-9. PMID: 12588009.
[11]	Pope D. S. and Chaisson R. E, (2003) “TB treatment: as simple as dot?” The International Journal of Tuberculosis and Lung Disease, vol. 7, no. 7, pp. 611–615.
[12]	Kieft, R. A., de Brouwer, B. B., Francke, A. L. et al. (2014). How nurses and their work environment affect patient experiences of the quality of care: a qualitative study. BMC Health Serv Res 14, 249 (2014). https://doi.org/10.1186/1472-6963-14-249.
[13]	Pradipta IS, Houtsma D, van Boven JFM, Alffenaar JC, Hak E. (2020). Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies. NPJ Prim Care Respir Med. 11; 30 (1): 21. doi: 10.1038/s41533-020-0179-x. PMID: 32393736; PMCID: PMC7214451.
[14]	Dahab, M., Charalambous, S., Hamilton, R. et al. "That is why I stopped the ART": Patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health 8, 63 (2008). https://doi.org/10.1186/1471-2458-8-63.
[15]	Tola, H. H, Tol, A, Shojaeizadeh, D & Garmaroudi, G. (2015). Tuberculosis Treatment Non-Adherence and Lost to Follow Up among TB Patients with or without HIV in Developing Countries: A Systematic Review. Iranian journal of public health, 44 (1), 1–11.
[16]	Obermeyer, Z., Abbott-Klafter, J. and Murray, C. J. L. (2008). “Has the DOTS strategy improved case finding or treatment success? an empirical assessment,” PLoS ONE, vol. 3, no. 3, Article ID e1721.
[17]	Yin, X. Tu, Y. Tong, R. Yang, Y. Wang, S. Cao, Hong Fan, Feng Wang, Yanhong Gong, Ping Yin, Zuxun Lu. (2012). “Development and validation of a tuberculosis medication adherence scale,” PLoS ONE, vol. 7, no. 12, Article ID e50328.
[18]	World Health Organization. (2011). Global Tuberculosis Control Report. WHO Press, Geneva, Switzerland.
[19]	Shibabaw A, Gelaw B, Gebreyes W, Robinson R, Wang S-H, Tessema B (2020) The burden of pre-extensively and extensively drug-resistant tuberculosis among MDR-TB patients in the Amhara region, Ethiopia. PLoS ONE 15 (2): e0229040. https://doi.org/10.1371/journal.pone.0229040.
[20]	Chiang Silver and Starke Jeffrey. (2018). Principles and Practice of Pediatric Infectious Diseases (fifth edition). Mycobacterium tuberculosis-134. Pages 790-806.e5.
[21]	OʼDonnell, M. R., Wolf, A., Werner, L., Horsburgh, C. R., & Padayatchi, N. (2014). Adherence in the treatment of patients with extensively drug-resistant tuberculosis and HIV in South Africa: a prospective cohort study. Journal of acquired immune deficiency syndromes (1999), 67 (1), 22–29. https://doi.org/10.1097/QAI.0000000000000221.
[22]	Lackey, N. R. and Wingate, A. L. (1998). The Pilot Study: One Key to Research Success. In P. J. Brink & M. J. Wood (Eds.). Thousand Oaks, CA: Sage.
[23]	Centre for Disease Control (2019) EPI INFO version 7 (StatCalc) sample size calculation for Case control studies using Open Epi.
[24]	Oladimeji Olanrewaju, Daniel Adedayo Adeyinka, Lehlogonolo Makola, Kabwebwe Honoré Mitonga, Ekerette Emmanuel Udoh, Boniface Ayanbekongshie Ushie, Kelechi Elizabeth Oladimeji, Jeremiah Chikovore, Musawenkosi Mabaso, Atilola Adeleke, Osman Eltayeb, Oluwatoyin J. Kuye, Gidado Mustapha, Olusoji Mayowa Ige, Joyce Nonhlanhla Mbatha, Jacob Creswell, Joyce M. Tsoka-Gwegweni, Lovett Lawson and Ehimario Uche Igumbor. (2018). Clients’ Perception of Quality of Multidrug-Resistant Tuberculosis Treatment and Care in Resource-Limited Setting: Experience from Nigeria. Intechopen: Research and development. 10: 190-206. http://dx.doi.org/10.5772/intechopen.76001.
[25]	World Health Organization. (2019). Global Tuberculosis Report 2019; World Health Organization: Geneva.
[26]	Olusoji Daniel, Eltayeb Osman, Olanrewaju Oladimeji and Olapade Gbolahan Dairo.(2013). Pre-Extensive Drug Resistant Tuberculosis (Pre-XDR-TB) among MDR-TB Patents in Nigeria. Global Advanced Research Journal of Microbiology. Vol. 2 (2) pp. 1-5. http://garj.org/garjm/index.htm.
[27]	Onyedum C. C., Alobu I., Ukwaja K. N. (2017). Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis. PLoS ONE 12 (7): e0180996. https:// doi. org/ 10. 1371 / journal.pone.0180996.

Cite This Article

Plain Text BibTeX RIS

APA Style

Laura Madukaji, Ebenezer Obi Daniel, Francis Ejeh, Adewole Olanisun Olufemi, Ahmed Mamuda Bello, et al. (2021). Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. International Journal of Infectious Diseases and Therapy, 6(3), 90-96. https://doi.org/10.11648/j.ijidt.20210603.12

Copy | Download

ACS Style

Laura Madukaji; Ebenezer Obi Daniel; Francis Ejeh; Adewole Olanisun Olufemi; Ahmed Mamuda Bello, et al. Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. Int. J. Infect. Dis. Ther. 2021, 6(3), 90-96. doi: 10.11648/j.ijidt.20210603.12

Copy | Download

AMA Style

Laura Madukaji, Ebenezer Obi Daniel, Francis Ejeh, Adewole Olanisun Olufemi, Ahmed Mamuda Bello, et al. Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. Int J Infect Dis Ther. 2021;6(3):90-96. doi: 10.11648/j.ijidt.20210603.12

Copy | Download

@article{10.11648/j.ijidt.20210603.12,
  author = {Laura Madukaji and Ebenezer Obi Daniel and Francis Ejeh and Adewole Olanisun Olufemi and Ahmed Mamuda Bello and Paul Olaiya Abiodun and Israel Olukayode Popoola and Kabir Yunusa Amari and Christiana Asibi Ogben and Michael Oladapo Olagbegi and Gabriel Omoniyi Ayeni and Olayinka Victor Ojo and John Danjuma Mawak},
  title = {Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {6},
  number = {3},
  pages = {90-96},
  doi = {10.11648/j.ijidt.20210603.12},
  url = {https://doi.org/10.11648/j.ijidt.20210603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210603.12},
  abstract = {The efforts geared towards control of Tuberculosis is threatened by the spread of multidrug resistance. Severe forms of multidrug resistant TB termed Pre-extensive (Pre-XDR) and Extensively Drug resistant (XDR) TB have been reported by different countries including Indian, China, Russia and Nigeria. Previous studies have shown a strong association between these various forms of resistance and non-adherence. The study was conducted to identify the factors affecting adherence, assess level of adherence and the perception of care among Multidrug resistant clients in North Central Nigeria. Specific & structures Questionnaires were administered to 96 MDR TB patients and 67 healthcare providers (representing 50% of each of the professional group). Few patients and healthcare providers were later selected from the number that responded to questionnaires and were involved in Focus Group Discussion. Responses from participants showed that the factors affecting adherence were alcohol addiction (72.9%), lack of social support (88.5%), feeling cured (28.1%), access to treatment centre (46.9%), non-payment & inadequate incentives/enablers for patients to continue treatment (38.5%), Stigma and discrimination (31.3%), financial difficulty (25%), treatment side effect (39.6%) and long treatment course & high pill burden (55.2%). Patients’ level of satisfaction on care was high (66.7%) indicating a satisfactory perception. This study revealed that factors affecting non-adherence were multifactorial and patients’ perception on MDR TB care was satisfactory.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria
AU  - Laura Madukaji
AU  - Ebenezer Obi Daniel
AU  - Francis Ejeh
AU  - Adewole Olanisun Olufemi
AU  - Ahmed Mamuda Bello
AU  - Paul Olaiya Abiodun
AU  - Israel Olukayode Popoola
AU  - Kabir Yunusa Amari
AU  - Christiana Asibi Ogben
AU  - Michael Oladapo Olagbegi
AU  - Gabriel Omoniyi Ayeni
AU  - Olayinka Victor Ojo
AU  - John Danjuma Mawak
Y1  - 2021/08/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ijidt.20210603.12
DO  - 10.11648/j.ijidt.20210603.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 90
EP  - 96
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20210603.12
AB  - The efforts geared towards control of Tuberculosis is threatened by the spread of multidrug resistance. Severe forms of multidrug resistant TB termed Pre-extensive (Pre-XDR) and Extensively Drug resistant (XDR) TB have been reported by different countries including Indian, China, Russia and Nigeria. Previous studies have shown a strong association between these various forms of resistance and non-adherence. The study was conducted to identify the factors affecting adherence, assess level of adherence and the perception of care among Multidrug resistant clients in North Central Nigeria. Specific & structures Questionnaires were administered to 96 MDR TB patients and 67 healthcare providers (representing 50% of each of the professional group). Few patients and healthcare providers were later selected from the number that responded to questionnaires and were involved in Focus Group Discussion. Responses from participants showed that the factors affecting adherence were alcohol addiction (72.9%), lack of social support (88.5%), feeling cured (28.1%), access to treatment centre (46.9%), non-payment & inadequate incentives/enablers for patients to continue treatment (38.5%), Stigma and discrimination (31.3%), financial difficulty (25%), treatment side effect (39.6%) and long treatment course & high pill burden (55.2%). Patients’ level of satisfaction on care was high (66.7%) indicating a satisfactory perception. This study revealed that factors affecting non-adherence were multifactorial and patients’ perception on MDR TB care was satisfactory.
VL  - 6
IS  - 3
ER  -

Copy | Download

Author Information

Laura Madukaji

Department of Public Health, Texila American University, Georgetown, Guyana
Ebenezer Obi Daniel

Department of Public Health, Texila American University, Georgetown, Guyana
Francis Ejeh

Department of Veterinary Microbiology, University of Maiduguri, Borno, Nigeria
Adewole Olanisun Olufemi

Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria
Ahmed Mamuda Bello

Department of Public Health, Texila American University, Georgetown, Guyana
Paul Olaiya Abiodun

Department of Public Health, Texila American University, Georgetown, Guyana
Israel Olukayode Popoola

Department of Epidemiology and Community Health, University of Ilorin, Ilorin, Nigeria
Kabir Yunusa Amari

Department of Psychology, Benue State University, Makurdi, Nigeria
Christiana Asibi Ogben

Department of Public Health, Texila American University, Georgetown, Guyana
Michael Oladapo Olagbegi

South African National Bioinformatics Institute, University of the Western Cape, Western Cape, South Africa
Gabriel Omoniyi Ayeni

Department of Public Health, Texila American University, Georgetown, Guyana
Olayinka Victor Ojo

Department of Public Health, Texila American University, Georgetown, Guyana
John Danjuma Mawak

Department of Microbiology, University of Jos, Plateau, Nigeria

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Laura Madukaji, Ebenezer Obi Daniel, Francis Ejeh, Adewole Olanisun Olufemi, Ahmed Mamuda Bello, et al. (2021). Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. International Journal of Infectious Diseases and Therapy, 6(3), 90-96. https://doi.org/10.11648/j.ijidt.20210603.12

Copy | Download

ACS Style

Laura Madukaji; Ebenezer Obi Daniel; Francis Ejeh; Adewole Olanisun Olufemi; Ahmed Mamuda Bello, et al. Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. Int. J. Infect. Dis. Ther. 2021, 6(3), 90-96. doi: 10.11648/j.ijidt.20210603.12

Copy | Download

AMA Style

Laura Madukaji, Ebenezer Obi Daniel, Francis Ejeh, Adewole Olanisun Olufemi, Ahmed Mamuda Bello, et al. Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria. Int J Infect Dis Ther. 2021;6(3):90-96. doi: 10.11648/j.ijidt.20210603.12

Copy | Download

@article{10.11648/j.ijidt.20210603.12,
  author = {Laura Madukaji and Ebenezer Obi Daniel and Francis Ejeh and Adewole Olanisun Olufemi and Ahmed Mamuda Bello and Paul Olaiya Abiodun and Israel Olukayode Popoola and Kabir Yunusa Amari and Christiana Asibi Ogben and Michael Oladapo Olagbegi and Gabriel Omoniyi Ayeni and Olayinka Victor Ojo and John Danjuma Mawak},
  title = {Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {6},
  number = {3},
  pages = {90-96},
  doi = {10.11648/j.ijidt.20210603.12},
  url = {https://doi.org/10.11648/j.ijidt.20210603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210603.12},
  abstract = {The efforts geared towards control of Tuberculosis is threatened by the spread of multidrug resistance. Severe forms of multidrug resistant TB termed Pre-extensive (Pre-XDR) and Extensively Drug resistant (XDR) TB have been reported by different countries including Indian, China, Russia and Nigeria. Previous studies have shown a strong association between these various forms of resistance and non-adherence. The study was conducted to identify the factors affecting adherence, assess level of adherence and the perception of care among Multidrug resistant clients in North Central Nigeria. Specific & structures Questionnaires were administered to 96 MDR TB patients and 67 healthcare providers (representing 50% of each of the professional group). Few patients and healthcare providers were later selected from the number that responded to questionnaires and were involved in Focus Group Discussion. Responses from participants showed that the factors affecting adherence were alcohol addiction (72.9%), lack of social support (88.5%), feeling cured (28.1%), access to treatment centre (46.9%), non-payment & inadequate incentives/enablers for patients to continue treatment (38.5%), Stigma and discrimination (31.3%), financial difficulty (25%), treatment side effect (39.6%) and long treatment course & high pill burden (55.2%). Patients’ level of satisfaction on care was high (66.7%) indicating a satisfactory perception. This study revealed that factors affecting non-adherence were multifactorial and patients’ perception on MDR TB care was satisfactory.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Adherence and Perception of Care Among Patients with Multidrug Resistant Tuberculosis in North Central Nigeria
AU  - Laura Madukaji
AU  - Ebenezer Obi Daniel
AU  - Francis Ejeh
AU  - Adewole Olanisun Olufemi
AU  - Ahmed Mamuda Bello
AU  - Paul Olaiya Abiodun
AU  - Israel Olukayode Popoola
AU  - Kabir Yunusa Amari
AU  - Christiana Asibi Ogben
AU  - Michael Oladapo Olagbegi
AU  - Gabriel Omoniyi Ayeni
AU  - Olayinka Victor Ojo
AU  - John Danjuma Mawak
Y1  - 2021/08/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ijidt.20210603.12
DO  - 10.11648/j.ijidt.20210603.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 90
EP  - 96
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20210603.12
AB  - The efforts geared towards control of Tuberculosis is threatened by the spread of multidrug resistance. Severe forms of multidrug resistant TB termed Pre-extensive (Pre-XDR) and Extensively Drug resistant (XDR) TB have been reported by different countries including Indian, China, Russia and Nigeria. Previous studies have shown a strong association between these various forms of resistance and non-adherence. The study was conducted to identify the factors affecting adherence, assess level of adherence and the perception of care among Multidrug resistant clients in North Central Nigeria. Specific & structures Questionnaires were administered to 96 MDR TB patients and 67 healthcare providers (representing 50% of each of the professional group). Few patients and healthcare providers were later selected from the number that responded to questionnaires and were involved in Focus Group Discussion. Responses from participants showed that the factors affecting adherence were alcohol addiction (72.9%), lack of social support (88.5%), feeling cured (28.1%), access to treatment centre (46.9%), non-payment & inadequate incentives/enablers for patients to continue treatment (38.5%), Stigma and discrimination (31.3%), financial difficulty (25%), treatment side effect (39.6%) and long treatment course & high pill burden (55.2%). Patients’ level of satisfaction on care was high (66.7%) indicating a satisfactory perception. This study revealed that factors affecting non-adherence were multifactorial and patients’ perception on MDR TB care was satisfactory.
VL  - 6
IS  - 3
ER  -

Copy | Download