Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients

Said H. Abdu; Doaa Shahin; Mohamed R. El-Shanshory; Hoda A. Salem; Eman A. Amer; Mohamed M. El-Shebeiny

doi:doi:10.11648/j.jctr.20140203.12

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Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients

Said H. Abdu, Doaa Shahin, Mohamed R. El-Shanshory, Hoda A. Salem, Eman A. Amer, Mohamed M. El-Shebeiny

Published in Journal of Cancer Treatment and Research (Volume 2, Issue 3)

Received: 24 May 2014 Accepted: 14 June 2014 Published: 20 July 2014

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Abstract

Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025). As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.

Published in	Journal of Cancer Treatment and Research (Volume 2, Issue 3)
DOI	10.11648/j.jctr.20140203.12
Page(s)	27-32
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

HOX11L2, HOX11, Real Time PCR, T-ALL

References

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APA Style

Said H. Abdu, Doaa Shahin, Mohamed R. El-Shanshory, Hoda A. Salem, Eman A. Amer, et al. (2014). Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. Journal of Cancer Treatment and Research, 2(3), 27-32. https://doi.org/10.11648/j.jctr.20140203.12

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ACS Style

Said H. Abdu; Doaa Shahin; Mohamed R. El-Shanshory; Hoda A. Salem; Eman A. Amer, et al. Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. J. Cancer Treat. Res. 2014, 2(3), 27-32. doi: 10.11648/j.jctr.20140203.12

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AMA Style

Said H. Abdu, Doaa Shahin, Mohamed R. El-Shanshory, Hoda A. Salem, Eman A. Amer, et al. Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. J Cancer Treat Res. 2014;2(3):27-32. doi: 10.11648/j.jctr.20140203.12

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@article{10.11648/j.jctr.20140203.12,
  author = {Said H. Abdu and Doaa Shahin and Mohamed R. El-Shanshory and Hoda A. Salem and Eman A. Amer and Mohamed M. El-Shebeiny},
  title = {Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients},
  journal = {Journal of Cancer Treatment and Research},
  volume = {2},
  number = {3},
  pages = {27-32},
  doi = {10.11648/j.jctr.20140203.12},
  url = {https://doi.org/10.11648/j.jctr.20140203.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20140203.12},
  abstract = {Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025).  As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.},
 year = {2014}
}

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TY  - JOUR
T1  - Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients
AU  - Said H. Abdu
AU  - Doaa Shahin
AU  - Mohamed R. El-Shanshory
AU  - Hoda A. Salem
AU  - Eman A. Amer
AU  - Mohamed M. El-Shebeiny
Y1  - 2014/07/20
PY  - 2014
N1  - https://doi.org/10.11648/j.jctr.20140203.12
DO  - 10.11648/j.jctr.20140203.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 27
EP  - 32
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20140203.12
AB  - Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025).  As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.
VL  - 2
IS  - 3
ER  -

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Author Information

Said H. Abdu

Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt
Doaa Shahin

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Mohamed R. El-Shanshory

Department of Pediatric, Faculty of Medicine, Tanta University, Tanta, Egypt
Hoda A. Salem

Department of Clinical Pharmacy, Faculty of pharmacy, Misr University for Science and Technology, Cairo, Egypt
Eman A. Amer

Biochemistry Department, Faculty of pharmacy, Modern Science and Art University, Cairo, Egypt
Mohamed M. El-Shebeiny

Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt

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APA Style

Said H. Abdu, Doaa Shahin, Mohamed R. El-Shanshory, Hoda A. Salem, Eman A. Amer, et al. (2014). Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. Journal of Cancer Treatment and Research, 2(3), 27-32. https://doi.org/10.11648/j.jctr.20140203.12

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ACS Style

Said H. Abdu; Doaa Shahin; Mohamed R. El-Shanshory; Hoda A. Salem; Eman A. Amer, et al. Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. J. Cancer Treat. Res. 2014, 2(3), 27-32. doi: 10.11648/j.jctr.20140203.12

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AMA Style

Said H. Abdu, Doaa Shahin, Mohamed R. El-Shanshory, Hoda A. Salem, Eman A. Amer, et al. Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients. J Cancer Treat Res. 2014;2(3):27-32. doi: 10.11648/j.jctr.20140203.12

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@article{10.11648/j.jctr.20140203.12,
  author = {Said H. Abdu and Doaa Shahin and Mohamed R. El-Shanshory and Hoda A. Salem and Eman A. Amer and Mohamed M. El-Shebeiny},
  title = {Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients},
  journal = {Journal of Cancer Treatment and Research},
  volume = {2},
  number = {3},
  pages = {27-32},
  doi = {10.11648/j.jctr.20140203.12},
  url = {https://doi.org/10.11648/j.jctr.20140203.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20140203.12},
  abstract = {Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025).  As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.},
 year = {2014}
}

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TY  - JOUR
T1  - Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients
AU  - Said H. Abdu
AU  - Doaa Shahin
AU  - Mohamed R. El-Shanshory
AU  - Hoda A. Salem
AU  - Eman A. Amer
AU  - Mohamed M. El-Shebeiny
Y1  - 2014/07/20
PY  - 2014
N1  - https://doi.org/10.11648/j.jctr.20140203.12
DO  - 10.11648/j.jctr.20140203.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 27
EP  - 32
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20140203.12
AB  - Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025).  As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.
VL  - 2
IS  - 3
ER  -

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