Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer

Elsayed M Ali; Emad Eldin Nabil; Ashraf Elyamany; Ahmed M. Maklad; Ahmed Gaber Abdelraheem

doi:doi:10.11648/j.jctr.20140204.12

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Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer

Elsayed M Ali, Emad Eldin Nabil, Ashraf Elyamany, Ahmed M. Maklad, Ahmed Gaber Abdelraheem

Published in Journal of Cancer Treatment and Research (Volume 2, Issue 4)

Received: 4 August 2014 Accepted: 20 August 2014 Published: 30 August 2014

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Abstract

PURPOSE: In our study we compared low-dose gemcitabine-based chemoradiotherapy with cisplatin-based chemoradiotherapy as regards response rate, survival and toxicity profile in locally advanced head and neck cancer. Methodology: sixty patients with locally advanced head and neck cancer were included in this prospective comparative randomized study, in the period from January 2011 to September 2013. Results: The patients were treated in two randomized groups; each of them included 30 patients. In gemcitabine arm (group A), 42.3% of the patients had stage III, and 57.7% of them had stage IVa while 48.15% of the patients of cisplatin arm (group B) had stage III and 51.85% had stage IVa. The median duration of response in group A was 21 months, while in group B it was 23 months. The degree of response had a statistically significant effect on survival in group B patients. It was evident in patients who achieved partial response (PR) that showed lower survival than those with (CR). Conclusion: Gemcitabine has comparable radiosensitizing effect with acceptable toxicity profile and can be used as a radiosensitizer in head and neck cancers especially when cisplatin cannot be used. We recommend further studies to establish its rule.

Published in	Journal of Cancer Treatment and Research (Volume 2, Issue 4)
DOI	10.11648/j.jctr.20140204.12
Page(s)	37-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Head and Neck, Radiotherapy, Chemotherapy, Gemcitabine, Cisplatin

References

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APA Style

Elsayed M Ali, Emad Eldin Nabil, Ashraf Elyamany, Ahmed M. Maklad, Ahmed Gaber Abdelraheem. (2014). Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. Journal of Cancer Treatment and Research, 2(4), 37-44. https://doi.org/10.11648/j.jctr.20140204.12

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ACS Style

Elsayed M Ali; Emad Eldin Nabil; Ashraf Elyamany; Ahmed M. Maklad; Ahmed Gaber Abdelraheem. Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. J. Cancer Treat. Res. 2014, 2(4), 37-44. doi: 10.11648/j.jctr.20140204.12

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AMA Style

Elsayed M Ali, Emad Eldin Nabil, Ashraf Elyamany, Ahmed M. Maklad, Ahmed Gaber Abdelraheem. Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. J Cancer Treat Res. 2014;2(4):37-44. doi: 10.11648/j.jctr.20140204.12

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@article{10.11648/j.jctr.20140204.12,
  author = {Elsayed M Ali and Emad Eldin Nabil and Ashraf Elyamany and Ahmed M. Maklad and Ahmed Gaber Abdelraheem},
  title = {Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer},
  journal = {Journal of Cancer Treatment and Research},
  volume = {2},
  number = {4},
  pages = {37-44},
  doi = {10.11648/j.jctr.20140204.12},
  url = {https://doi.org/10.11648/j.jctr.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20140204.12},
  abstract = {PURPOSE: In our study we compared low-dose gemcitabine-based chemoradiotherapy with cisplatin-based chemoradiotherapy as regards response rate, survival and toxicity profile in locally advanced head and neck cancer. Methodology: sixty patients with locally advanced head and neck cancer were included in this prospective comparative randomized study, in the period from January 2011 to September 2013. Results: The patients were treated in two randomized groups; each of them included 30 patients. In gemcitabine arm (group A), 42.3% of the patients had stage III, and 57.7% of them had stage IVa while 48.15% of the patients of cisplatin arm (group B) had stage III and 51.85% had stage IVa. The median duration of response in group A was 21 months, while in group B it was 23 months. The degree of response had a statistically significant effect on survival in group B patients. It was evident in patients who achieved partial response (PR) that showed lower survival than those with (CR). Conclusion: Gemcitabine has comparable radiosensitizing  effect with acceptable toxicity profile and can be used as a radiosensitizer in head and neck cancers especially when cisplatin cannot be used. We recommend further studies to establish its rule.},
 year = {2014}
}

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TY - JOUR
T1 - Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer
AU - Elsayed M Ali
AU - Emad Eldin Nabil
AU - Ashraf Elyamany
AU - Ahmed M. Maklad
AU - Ahmed Gaber Abdelraheem
Y1 - 2014/08/30
PY - 2014
N1 - https://doi.org/10.11648/j.jctr.20140204.12
DO - 10.11648/j.jctr.20140204.12
T2 - Journal of Cancer Treatment and Research
JF - Journal of Cancer Treatment and Research
JO - Journal of Cancer Treatment and Research
SP - 37
EP - 44
PB - Science Publishing Group
SN - 2376-7790
UR - https://doi.org/10.11648/j.jctr.20140204.12
AB - PURPOSE: In our study we compared low-dose gemcitabine-based chemoradiotherapy with cisplatin-based chemoradiotherapy as regards response rate, survival and toxicity profile in locally advanced head and neck cancer. Methodology: sixty patients with locally advanced head and neck cancer were included in this prospective comparative randomized study, in the period from January 2011 to September 2013. Results: The patients were treated in two randomized groups; each of them included 30 patients. In gemcitabine arm (group A), 42.3% of the patients had stage III, and 57.7% of them had stage IVa while 48.15% of the patients of cisplatin arm (group B) had stage III and 51.85% had stage IVa. The median duration of response in group A was 21 months, while in group B it was 23 months. The degree of response had a statistically significant effect on survival in group B patients. It was evident in patients who achieved partial response (PR) that showed lower survival than those with (CR). Conclusion: Gemcitabine has comparable radiosensitizing effect with acceptable toxicity profile and can be used as a radiosensitizer in head and neck cancers especially when cisplatin cannot be used. We recommend further studies to establish its rule.
VL - 2
IS - 4
ER -

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Author Information

Elsayed M Ali

Clinical Oncology Department, Sohag University, Sohag, Egypt
Emad Eldin Nabil

Clinical Oncology Department, Sohag University, Sohag, Egypt
Ashraf Elyamany

Medical Oncology Department SECI, Assiut University, Assiut, Egypt, KFMC, KSA
Ahmed M. Maklad

Clinical Oncology Department, Sohag University, Sohag, Egypt, KFMC, KSA
Ahmed Gaber Abdelraheem

ENT Department, Faculty of Medicine, South Valley University, Qena, po 83523, Egypt

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APA Style

Elsayed M Ali, Emad Eldin Nabil, Ashraf Elyamany, Ahmed M. Maklad, Ahmed Gaber Abdelraheem. (2014). Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. Journal of Cancer Treatment and Research, 2(4), 37-44. https://doi.org/10.11648/j.jctr.20140204.12

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ACS Style

Elsayed M Ali; Emad Eldin Nabil; Ashraf Elyamany; Ahmed M. Maklad; Ahmed Gaber Abdelraheem. Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. J. Cancer Treat. Res. 2014, 2(4), 37-44. doi: 10.11648/j.jctr.20140204.12

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AMA Style

Elsayed M Ali, Emad Eldin Nabil, Ashraf Elyamany, Ahmed M. Maklad, Ahmed Gaber Abdelraheem. Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer. J Cancer Treat Res. 2014;2(4):37-44. doi: 10.11648/j.jctr.20140204.12

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@article{10.11648/j.jctr.20140204.12,
  author = {Elsayed M Ali and Emad Eldin Nabil and Ashraf Elyamany and Ahmed M. Maklad and Ahmed Gaber Abdelraheem},
  title = {Comparative Study of Gemcitabine Versus Cisplatin Concurrent with Radiotherapy for Locally Advanced Head and Neck Cancer},
  journal = {Journal of Cancer Treatment and Research},
  volume = {2},
  number = {4},
  pages = {37-44},
  doi = {10.11648/j.jctr.20140204.12},
  url = {https://doi.org/10.11648/j.jctr.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20140204.12},
  abstract = {PURPOSE: In our study we compared low-dose gemcitabine-based chemoradiotherapy with cisplatin-based chemoradiotherapy as regards response rate, survival and toxicity profile in locally advanced head and neck cancer. Methodology: sixty patients with locally advanced head and neck cancer were included in this prospective comparative randomized study, in the period from January 2011 to September 2013. Results: The patients were treated in two randomized groups; each of them included 30 patients. In gemcitabine arm (group A), 42.3% of the patients had stage III, and 57.7% of them had stage IVa while 48.15% of the patients of cisplatin arm (group B) had stage III and 51.85% had stage IVa. The median duration of response in group A was 21 months, while in group B it was 23 months. The degree of response had a statistically significant effect on survival in group B patients. It was evident in patients who achieved partial response (PR) that showed lower survival than those with (CR). Conclusion: Gemcitabine has comparable radiosensitizing  effect with acceptable toxicity profile and can be used as a radiosensitizer in head and neck cancers especially when cisplatin cannot be used. We recommend further studies to establish its rule.},
 year = {2014}
}

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