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Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review

Received: 13 December 2014     Accepted: 23 December 2014     Published: 4 January 2015
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Abstract

Although Prostate cancer is the most frequently diagnosed cancer among men globally, its primary presentation as Epistaxis alone is quit uncommon. Epistaxis has numerous causes and hence poses early diagnostic challenge. We report a case of 68 year old man who presented with recurrent epistaxis as the main complaint .He was thoroughly evaluated and concluded to have a background asymptomatic advanced prostate cancer with isolated thrombocytopenia. He responded to blood transfusion and combined therapy form of Anti-androgen Deprivation Therapy. High index of suspicion is of paramount importance towards achieving early diagnosis of this unusual presentation.

Published in Journal of Cancer Treatment and Research (Volume 2, Issue 6)
DOI 10.11648/j.jctr.20140206.12
Page(s) 61-63
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Prostate Cancer, Epistaxis, Thrombocytopenia

References
[1] Ogunbiyi JO, Shittu OB. Increased incidence of prostate cancer in Nigerians. J Natl Med Assoc. Mar 1999; 91(3):159-64
[2] Mohammed AZ, Edino ST, Ochicha O, Gwarzo AK, Samaila AA. Cancer in Nigeria: a 10-year analysis of the Kano cancer registry. Niger J Med. Jul-Aug 2008; 17(3):280-4
[3] Badmus TA, Adesunkanmi AR, Yusuf BM, et al. Burden of prostate cancer in southwestern Nigeria. Urology. Aug 2010; 76(2):412-6.
[4] Olapade-Olaopa E Oluwabunmi, Obamuyide H Adebayo, Yisa Gloria T. Management of advanced prostate cancer in Africa. CJU,2008;15(1):3890-3898
[5] Randall DA, Freeman SB: Management of anterior and posterior epistaxis; Am Fam Physician. 1991 Jun;43(6):2007-14.
[6] Mehmet Ali Erkurt, Emin Kaya, Ilhami Berber, Mustafa Koroglu, Irfan Kuku, Thrombocytopenia in Adults: Review Article, J Haematol Volume 1, Number 2-3, June 2012, pages 44-53
[7] Anner RM, Drewinko B: Frequency and significance of bone marrow involvement by metastatic solid tumors. Cancer. 1977;39:1337–1344
[8] Kilickap S, Erman M, Dincer M, Aksoy S, Hakan H, Yalcin Y. Bone marrow metastasis of solid tumors: clinicopathological evaluation of 73 cases. Turk J Cancer. 2007;37(3):85–88
[9] Salako AA, Arowolo OA, Omonisi EA, Adisa AO, Titiloye NA, Adelusola K: Incidental carcinoma of the prostate gland presenting with initial manifestation of disseminated intravascular coagulopathy (dic) in a middle aged man: a case report. Cases J. 2009 Sep 29; 2:144. doi: 10.1186/1757-1626-2-14
[10] Lim H Y, Agarwal A M, Agarwal N, Ward J H: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer, Singapore Med J 2009; 50(5) : e178
[11] de la Fouchardière C, Flechon A, Droz JP: Coagulopathy in prostate cancer; Neth J Med 2003 Nov;61(11 ):347-54.
[12] Ignacio Duran, Ian F Tannock: Disseminated Intravascular Coagulation as the Presenting Sign of Metastatic Prostate Cancer; J Gen Intern Med. 2006 November; 21(11): C6–C8
[13] Emmanuel S. Antonarakis, Michael A. Carducci, Mario A. Eisenberger: Treatment of Castration-Resistant Prostate Cancer, Campbell-Walsh Urology, 10th Edition, Vol 3, chapter 110, p.2958.
[14] Karen A. Autio, Howard I. Scher, Michael J. Morris: Therapeutic Strategies for Bone Metastases and Their Clinical Sequelae in Prostate Cancer, Curr Treat Options Oncol. Jun 2012; 13(2): 174–188.
Cite This Article
  • APA Style

    Usman Mohammed Tela, Audu Abdullahi Bukar, Mala Bukar Sandabe, Theophilus Maksha Dabkana, Alhaji Bukar Musa, et al. (2015). Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review. Journal of Cancer Treatment and Research, 2(6), 61-63. https://doi.org/10.11648/j.jctr.20140206.12

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    ACS Style

    Usman Mohammed Tela; Audu Abdullahi Bukar; Mala Bukar Sandabe; Theophilus Maksha Dabkana; Alhaji Bukar Musa, et al. Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review. J. Cancer Treat. Res. 2015, 2(6), 61-63. doi: 10.11648/j.jctr.20140206.12

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    AMA Style

    Usman Mohammed Tela, Audu Abdullahi Bukar, Mala Bukar Sandabe, Theophilus Maksha Dabkana, Alhaji Bukar Musa, et al. Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review. J Cancer Treat Res. 2015;2(6):61-63. doi: 10.11648/j.jctr.20140206.12

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  • @article{10.11648/j.jctr.20140206.12,
      author = {Usman Mohammed Tela and Audu Abdullahi Bukar and Mala Bukar Sandabe and Theophilus Maksha Dabkana and Alhaji Bukar Musa and Abubakar Sadiq Adamu},
      title = {Advanced Prostate Cancer Presenting as Epistaxis Only: A Case Report and Literature Review},
      journal = {Journal of Cancer Treatment and Research},
      volume = {2},
      number = {6},
      pages = {61-63},
      doi = {10.11648/j.jctr.20140206.12},
      url = {https://doi.org/10.11648/j.jctr.20140206.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20140206.12},
      abstract = {Although Prostate cancer is the most frequently diagnosed cancer among men globally, its primary presentation as Epistaxis alone is quit uncommon. Epistaxis has numerous causes and hence poses early diagnostic challenge. We report a case of 68 year old man who presented with recurrent epistaxis as the main complaint .He was thoroughly evaluated and concluded to have a background asymptomatic advanced prostate cancer with isolated thrombocytopenia. He responded to blood transfusion and combined therapy form of Anti-androgen Deprivation Therapy. High index of suspicion is of paramount importance towards achieving early diagnosis of this unusual presentation.},
     year = {2015}
    }
    

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    AB  - Although Prostate cancer is the most frequently diagnosed cancer among men globally, its primary presentation as Epistaxis alone is quit uncommon. Epistaxis has numerous causes and hence poses early diagnostic challenge. We report a case of 68 year old man who presented with recurrent epistaxis as the main complaint .He was thoroughly evaluated and concluded to have a background asymptomatic advanced prostate cancer with isolated thrombocytopenia. He responded to blood transfusion and combined therapy form of Anti-androgen Deprivation Therapy. High index of suspicion is of paramount importance towards achieving early diagnosis of this unusual presentation.
    VL  - 2
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Author Information
  • Urology unit, Department of Surgery, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

  • Department of Haematology, Universiy of Maiduguri Teaching Hospital, Maiduguri, Nigeria

  • Department of Ear, Nose and Throat (ENT), University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

  • Departtment of Orthopedics, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

  • Department of Histopathology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

  • Department of Anaesthesia, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

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