Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review

Hemalatha Narayanasamy; Nikky Bardia; Michael Fong; Luanda Grazette

doi:doi:10.11648/j.jctr.20150303.12

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Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review

Hemalatha Narayanasamy, Nikky Bardia, Michael Fong, Luanda Grazette

Published in Journal of Cancer Treatment and Research (Volume 3, Issue 3)

Received: 3 March 2015 Accepted: 23 March 2015 Published: 21 April 2015

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Abstract

Background: Cardiac dysfunction is an unusual but documented side effect of many forms of antineoplastic therapy. Bevacizumab is a novel antineoplastic agent that inhibits VEGF-A with a low reported incidence of cardiotoxicity (1.7 - 3%) derived primarily from clinical trials of women with breast cancer which captured adverse events of symptomatic heart failure. Subsequent studies suggest the incidence of asymptomatic decline in cardiac function may be closer to 20%. Untreated declines in cardiac function are associated with increased morbidity and mortality, early recognition and treatment can improve outcomes. Case Report: Here we describe a case of a 51 year old male being treated with Bevacizumab for metastatic neuroendocrine cancer of the colon who developed a severe asymptomatic decline in cardiac function. With interruption of Bevacizumab and implementation of heart failure therapy his cardiac function returned to baseline. Conclusion: Early recognition and application of heart failure disease modifying therapy can decrease the risk and improve the likelihood of recovery in cases of chemotherapy induced cardiac dysfunction. Baseline cardiac testing and standardized surveillance can increase the opportunities for early intervention and may improve long term outcomes.

Published in	Journal of Cancer Treatment and Research (Volume 3, Issue 3)
DOI	10.11648/j.jctr.20150303.12
Page(s)	32-36
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Heart Failure, Chemotherapy, Cardiotoxic Agents, Bevacizumab, Cardiac Remodeling, Ventricular

References

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APA Style

Hemalatha Narayanasamy, Nikky Bardia, Michael Fong, Luanda Grazette. (2015). Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. Journal of Cancer Treatment and Research, 3(3), 32-36. https://doi.org/10.11648/j.jctr.20150303.12

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ACS Style

Hemalatha Narayanasamy; Nikky Bardia; Michael Fong; Luanda Grazette. Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. J. Cancer Treat. Res. 2015, 3(3), 32-36. doi: 10.11648/j.jctr.20150303.12

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AMA Style

Hemalatha Narayanasamy, Nikky Bardia, Michael Fong, Luanda Grazette. Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. J Cancer Treat Res. 2015;3(3):32-36. doi: 10.11648/j.jctr.20150303.12

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@article{10.11648/j.jctr.20150303.12,
  author = {Hemalatha Narayanasamy and Nikky Bardia and Michael Fong and Luanda Grazette},
  title = {Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review},
  journal = {Journal of Cancer Treatment and Research},
  volume = {3},
  number = {3},
  pages = {32-36},
  doi = {10.11648/j.jctr.20150303.12},
  url = {https://doi.org/10.11648/j.jctr.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20150303.12},
  abstract = {Background: Cardiac dysfunction is an unusual but documented side effect of many forms of antineoplastic therapy. Bevacizumab is a novel antineoplastic agent that inhibits VEGF-A with a low reported incidence of cardiotoxicity (1.7 - 3%) derived primarily from clinical trials of women with breast cancer which captured adverse events of symptomatic heart failure. Subsequent studies suggest the incidence of asymptomatic decline in cardiac function may be closer to 20%. Untreated declines in cardiac function are associated with increased morbidity and mortality, early recognition and treatment can improve outcomes. Case Report: Here we describe a case of a 51 year old male being treated with Bevacizumab for metastatic neuroendocrine cancer of the colon who developed a severe asymptomatic decline in cardiac function. With interruption of Bevacizumab and implementation of heart failure therapy his cardiac function returned to baseline. Conclusion: Early recognition and application of heart failure disease modifying therapy can decrease the risk and improve the likelihood of recovery in cases of chemotherapy induced cardiac dysfunction. Baseline cardiac testing and standardized surveillance can increase the opportunities for early intervention and may improve long term outcomes.},
 year = {2015}
}

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TY  - JOUR
T1  - Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review
AU  - Hemalatha Narayanasamy
AU  - Nikky Bardia
AU  - Michael Fong
AU  - Luanda Grazette
Y1  - 2015/04/21
PY  - 2015
N1  - https://doi.org/10.11648/j.jctr.20150303.12
DO  - 10.11648/j.jctr.20150303.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 32
EP  - 36
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20150303.12
AB  - Background: Cardiac dysfunction is an unusual but documented side effect of many forms of antineoplastic therapy. Bevacizumab is a novel antineoplastic agent that inhibits VEGF-A with a low reported incidence of cardiotoxicity (1.7 - 3%) derived primarily from clinical trials of women with breast cancer which captured adverse events of symptomatic heart failure. Subsequent studies suggest the incidence of asymptomatic decline in cardiac function may be closer to 20%. Untreated declines in cardiac function are associated with increased morbidity and mortality, early recognition and treatment can improve outcomes. Case Report: Here we describe a case of a 51 year old male being treated with Bevacizumab for metastatic neuroendocrine cancer of the colon who developed a severe asymptomatic decline in cardiac function. With interruption of Bevacizumab and implementation of heart failure therapy his cardiac function returned to baseline. Conclusion: Early recognition and application of heart failure disease modifying therapy can decrease the risk and improve the likelihood of recovery in cases of chemotherapy induced cardiac dysfunction. Baseline cardiac testing and standardized surveillance can increase the opportunities for early intervention and may improve long term outcomes.
VL  - 3
IS  - 3
ER  -

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Author Information

Hemalatha Narayanasamy

Keck School of Medicine of USC, Department of Medicine, Los Angles, California, USA
Nikky Bardia

Keck School of Medicine of USC, Department of Medicine, Los Angles, California, USA
Michael Fong

Division of Cardiovascular Medicine, Keck Medical Center of USC, University of Southern California, Los Angeles, California, USA
Luanda Grazette

Division of Cardiovascular Medicine, Keck Medical Center of USC, University of Southern California, Los Angeles, California, USA

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Plain Text BibTeX RIS

APA Style

Hemalatha Narayanasamy, Nikky Bardia, Michael Fong, Luanda Grazette. (2015). Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. Journal of Cancer Treatment and Research, 3(3), 32-36. https://doi.org/10.11648/j.jctr.20150303.12

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ACS Style

Hemalatha Narayanasamy; Nikky Bardia; Michael Fong; Luanda Grazette. Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. J. Cancer Treat. Res. 2015, 3(3), 32-36. doi: 10.11648/j.jctr.20150303.12

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AMA Style

Hemalatha Narayanasamy, Nikky Bardia, Michael Fong, Luanda Grazette. Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review. J Cancer Treat Res. 2015;3(3):32-36. doi: 10.11648/j.jctr.20150303.12

Copy | Download

@article{10.11648/j.jctr.20150303.12,
  author = {Hemalatha Narayanasamy and Nikky Bardia and Michael Fong and Luanda Grazette},
  title = {Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review},
  journal = {Journal of Cancer Treatment and Research},
  volume = {3},
  number = {3},
  pages = {32-36},
  doi = {10.11648/j.jctr.20150303.12},
  url = {https://doi.org/10.11648/j.jctr.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20150303.12},
  abstract = {Background: Cardiac dysfunction is an unusual but documented side effect of many forms of antineoplastic therapy. Bevacizumab is a novel antineoplastic agent that inhibits VEGF-A with a low reported incidence of cardiotoxicity (1.7 - 3%) derived primarily from clinical trials of women with breast cancer which captured adverse events of symptomatic heart failure. Subsequent studies suggest the incidence of asymptomatic decline in cardiac function may be closer to 20%. Untreated declines in cardiac function are associated with increased morbidity and mortality, early recognition and treatment can improve outcomes. Case Report: Here we describe a case of a 51 year old male being treated with Bevacizumab for metastatic neuroendocrine cancer of the colon who developed a severe asymptomatic decline in cardiac function. With interruption of Bevacizumab and implementation of heart failure therapy his cardiac function returned to baseline. Conclusion: Early recognition and application of heart failure disease modifying therapy can decrease the risk and improve the likelihood of recovery in cases of chemotherapy induced cardiac dysfunction. Baseline cardiac testing and standardized surveillance can increase the opportunities for early intervention and may improve long term outcomes.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Bevacizumab Induced Cardiomyopathy in a Patient with Adult Congenital Heart Disease: A Case Report and Brief Review
AU  - Hemalatha Narayanasamy
AU  - Nikky Bardia
AU  - Michael Fong
AU  - Luanda Grazette
Y1  - 2015/04/21
PY  - 2015
N1  - https://doi.org/10.11648/j.jctr.20150303.12
DO  - 10.11648/j.jctr.20150303.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 32
EP  - 36
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20150303.12
AB  - Background: Cardiac dysfunction is an unusual but documented side effect of many forms of antineoplastic therapy. Bevacizumab is a novel antineoplastic agent that inhibits VEGF-A with a low reported incidence of cardiotoxicity (1.7 - 3%) derived primarily from clinical trials of women with breast cancer which captured adverse events of symptomatic heart failure. Subsequent studies suggest the incidence of asymptomatic decline in cardiac function may be closer to 20%. Untreated declines in cardiac function are associated with increased morbidity and mortality, early recognition and treatment can improve outcomes. Case Report: Here we describe a case of a 51 year old male being treated with Bevacizumab for metastatic neuroendocrine cancer of the colon who developed a severe asymptomatic decline in cardiac function. With interruption of Bevacizumab and implementation of heart failure therapy his cardiac function returned to baseline. Conclusion: Early recognition and application of heart failure disease modifying therapy can decrease the risk and improve the likelihood of recovery in cases of chemotherapy induced cardiac dysfunction. Baseline cardiac testing and standardized surveillance can increase the opportunities for early intervention and may improve long term outcomes.
VL  - 3
IS  - 3
ER  -

Copy | Download