A Review on the Benefits of <i>Allium sativum</i> on Cancer Prevention

Thejasenuo Julia Kirha; Tsipila Thonger; Sanjay Kumar

doi:doi:10.11648/j.jctr.20160405.11

| Peer-Reviewed

A Review on the Benefits of Allium sativum on Cancer Prevention

Thejasenuo Julia Kirha, Tsipila Thonger, Sanjay Kumar

Published in Journal of Cancer Treatment and Research (Volume 4, Issue 5)

Received: 30 August 2016 Accepted: 10 February 2017 Published: 17 March 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

An important and oldest plant, Garlic (Allium sativum L.), cultivated since time immemorial for its use as food and medicine, has many important constituents which requires attention for its many health benefits. It contains sulfur compounds which are responsible for garlic’s medicinal effects and pungent odour. Pharmacological activities such as antimicrobial, antitumor, hypoglycemic and hypolipidemic activities have been reported. Out of the medicinal effects of garlic, one of the main factor or importance of garlic is its potentialities in the treatment of cancer or prevention in cancer development. It contains an important organo sulfur compounds which have been attributed in its impact on inhibition of tumour growth, antioxidant properties and drug metabolizing enzymes. Due to garlic’s valuable medicinal properties, special focus has been made on its cancer prevention and its constituents.

Published in	Journal of Cancer Treatment and Research (Volume 4, Issue 5)
DOI	10.11648/j.jctr.20160405.11
Page(s)	34-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Allium sativum, Organosulfur, Cancer Prevention

References

[1]	Eiaz LCS, Woong, Eiaz A. 2003. Allium vegetables and stomach cancer risk in China. Experimental Oncology: 23-93.
[2]	Tattelman Ellen. Health Effects of Garlic. 2005. American Family Physician, 72 (1): 103-106.
[3]	Ariga T, Seki T. 2006. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Bio Factors, 26 (2): 93-103.
[4]	Hassan HT. 2004. Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leukemia Research, 28 (7): 667-671.
[5]	Block E, Ahmad S, Catalfamo JL, Jain M K, Apitz-Castro R. 1986. The chemistry of alkyl thiosulfinate esters. Antithrombotic organosulfur compounds from garlic: structural mechanistic and synthetic studies. J. Am. Chem. Soc, 108 (22): 7045–7055.
[6]	Shukla Y, Kalra N. 2007. Cancer chemoprevention with garlic and its constituents. Cancer Lett, 247: 167–181.
[7]	Herman-Antosiewicz A, Singh SV. 2004. Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable derived organosulfur componds: a review. Mut. Res, 555: 121–131.
[8]	Schaffer EM, Liu JZ, Green J, Dangler CA, Milner JA.. 1996. Garlic and associated allyl sulphur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis. Cancer Lett, 102 (1-2): 199–204.
[9]	Thomson M, Ali M. Garlic (Allium sativum): a review of its potential use as an anti-cancer agent. Current Cancer Drug Targets. 2003; 3 (1): 67.
[10]	Schafer G, Kaschula CH. 2014. The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention. Anticancer Agents and Medicinal Chemistry, 14 (2): 233-240.
[11]	Ejaz S, Woong LC, Ejaz A et al., 2003. Extract of garlic (allium sativum) in cancer chemoprevention. Experimental oncolog, 25: 93-97.
[12]	Islam MS, Kusumoto Y, Al-Mamun MA et al., 2011. Cytotoxicity and Cancer (HeLa) Cell Killing Efficacy of Aqueous Garlic (Allium sativum) Extract. J. Sci. Res, (2): 375-382.
[13]	Lau BHS, Tadi PP, Tosk JM et al., 1990. Allium sativum (garlic) and cancer prevention. Nutrition research, 10: 937-948.
[14]	Dirsch VM, Gerbes AL, Volmar AM. 1998. Ajoene a compound of garlic induces apoptosis in human promyleoleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kB. Mol. Pharmacol, 53: 402–407.
[15]	Kwon KB, Yoo SJ, Ryu DG, Yang JY, Rho HW, Kim JS, Park JW, Kim HR, Park BH. 2002. Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem. Pharmacol, 63 (1): 41–47.
[16]	Filomeni G, Aquilano K, Rotilio G, Ciriolo MR. 2003. Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res, 63 (18): 5940–5949.
[17]	Kelkel M, Cerella C, Mack F, Schneider T, Jacob C, Schumacher M, Dicato M, Diederich M. 2012. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis, 33 (11): 2162–2171.
[18]	Antosiewicz AH, Powolny AA, Singh SV. 2007. Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacology, 28 (9): 1355-1364.
[19]	Cerella C, Dicato M, Jacob C, Diederich M.. 2011. Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds. Anti-Cancer Agents in Medicinal Chemistry, 11 (3): 267-271.
[20]	Schafer G, Kaschula CH. 2014. The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention. Anticancer Agents and Medicinal Chemistry, 14 (2): 233-240.
[21]	Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Bio Factors, 2006; 26 (2): 93-103.
[22]	Ferguson LR, Philpott M. 2007. Cancer prevention by dietary bioactive components that target the immune response. Curr. Cancer Drug Targets, 7 (5): 459–464.
[23]	Jacobs EJ, Thun MJ, Bain EB, Rodriguez C, Henley SJ, Calle EE. 2007. A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. J. Natl. Cancer Inst, 99 (8): 608–615.
[24]	Ghalambor A, Pipelzadeh MH. 2009. Clinical study on the efficacy of orally administered crushed fresh garlic in controlling Pseudomonas aeruginosa infection in burn patients with varying burn degrees. Journal of Microbiology, 2 (1): 7-13.
[25]	Fleischauer AT, Arab L. 2001. Garlic and cancer: A critical review of the epidemiologic literature. Journal of Nutrition, 131 (3): 1032-1040.
[26]	González CA, PeraG, AgudoA, Bueno-de-MesquitaHB, CerotiM, BoeingH, Schulz M, Giudice GD, Plebani M, CarneiroF, Berrino F, Sacerdote C, Tumino R, Panico S, BerglundG, SimánH, Hallmans G, StenlingR, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, AllenN, Key TJ, Bingham S, Day NE, Linseisen J, Nagel G, Overvad K, Jensen MK, Olsen A, Tjønneland A, Büchner FL, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron-Ruault MC, Roukos D, Trichopoulou A, Psaltopoulou T, Lund E, Casagrande C, Slimani N, Jenab M and Riboli E. 2006. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 118 (10): 2559-2566.
[27]	Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF. 2002. Allium vegetables and risk of prostate cancer: A population-based study. Journal of the National Cancer Institute, 94 (21): 1648-1651.
[28]	Chan JM, Wang F, Holly EA. 2005. Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay area. Cancer Epidemiology, Biomarkers & Prevention, 14 (9): 2093-2097.
[29]	Ngo SN, Williams DB, Cobiac L, Head RJ. 2007. Does garlic reduce risk of colorectal cancer? A systematic review. Journal of Nutrition, 137: 2264-2269.
[30]	Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD. 1994. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Am J Epidemiol, 139 (1): 1-15.
[31]	Gao CM, Takezaki T, Ding JH, Li MS, Tajima K. 1999. Protective effect of Allium vegetables against both esophageal and stomach cancer: A simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. Japanese Journal of Cancer Research, 90 (6): 614–621.
[32]	Challier B, Perarnau JM, Viel JF. 1998. Garlic, onion and cereal fibre as protective factors for breast cancer: A French case-control study. European Journal of Epidemiology, 14 (8): 737–747.
[33]	Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A, Maldonado PD. The antioxidant mechanisms underlying the aged garlic extract-and S-allylcysteine-induced protection. Oxid Med Cell Longev, 2012; 2012: 907-162.
[34]	Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. 2009. Garlic: empiricism or science?. Nat Prod Commun, 4: 1785–1796.
[35]	Li H, Li HQ, Wang Y, et al., 2004. An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum. Chinese Medical Journal (English), 117 (8): 1155–1160.
[36]	Tanaka S, Haruma K, Kunihiro M, et al., 2004. Effects of aged garlic extract (AGE) on colorectal adenomas: A double-blinded study. Hiroshima Journal of Medical Sciences, 53 (3–4): 39–45.
[37]	Omar SH and Wabel NAA. 2010. Organosulfur compounds and possible mechanism of garlic in cancer. Saudi Pharmacology, 18 (1): 51-58.
[38]	Bhandari PR. 2012. Garlic (Allium sativum L): A review of potential therapeutic applications. International journal green pharmacy, 6: 118-129.
[39]	Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J. 2002. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clinical Infectious Diseases, 34 (2): 234-238.
[40]	Amagase H. 2006. Clarifying the real bioactive constituents of garlic. Journal of Nutrition, 136 (3): 716-725.

Cite This Article

Plain Text BibTeX RIS

APA Style

Thejasenuo Julia Kirha, Tsipila Thonger, Sanjay Kumar. (2017). A Review on the Benefits of Allium sativum on Cancer Prevention. Journal of Cancer Treatment and Research, 4(5), 34-37. https://doi.org/10.11648/j.jctr.20160405.11

Copy | Download

ACS Style

Thejasenuo Julia Kirha; Tsipila Thonger; Sanjay Kumar. A Review on the Benefits of Allium sativum on Cancer Prevention. J. Cancer Treat. Res. 2017, 4(5), 34-37. doi: 10.11648/j.jctr.20160405.11

Copy | Download

AMA Style

Thejasenuo Julia Kirha, Tsipila Thonger, Sanjay Kumar. A Review on the Benefits of Allium sativum on Cancer Prevention. J Cancer Treat Res. 2017;4(5):34-37. doi: 10.11648/j.jctr.20160405.11

Copy | Download

@article{10.11648/j.jctr.20160405.11,
  author = {Thejasenuo Julia Kirha and Tsipila Thonger and Sanjay Kumar},
  title = {A Review on the Benefits of Allium sativum on Cancer Prevention},
  journal = {Journal of Cancer Treatment and Research},
  volume = {4},
  number = {5},
  pages = {34-37},
  doi = {10.11648/j.jctr.20160405.11},
  url = {https://doi.org/10.11648/j.jctr.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20160405.11},
  abstract = {An important and oldest plant, Garlic (Allium sativum L.), cultivated since time immemorial for its use as food and medicine, has many important constituents which requires attention for its many health benefits. It contains sulfur compounds which are responsible for garlic’s medicinal effects and pungent odour. Pharmacological activities such as antimicrobial, antitumor, hypoglycemic and hypolipidemic activities have been reported. Out of the medicinal effects of garlic, one of the main factor or importance of garlic is its potentialities in the treatment of cancer or prevention in cancer development. It contains an important organo sulfur compounds which have been attributed in its impact on inhibition of tumour growth, antioxidant properties and drug metabolizing enzymes. Due to garlic’s valuable medicinal properties, special focus has been made on its cancer prevention and its constituents.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - A Review on the Benefits of Allium sativum on Cancer Prevention
AU  - Thejasenuo Julia Kirha
AU  - Tsipila Thonger
AU  - Sanjay Kumar
Y1  - 2017/03/17
PY  - 2017
N1  - https://doi.org/10.11648/j.jctr.20160405.11
DO  - 10.11648/j.jctr.20160405.11
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20160405.11
AB  - An important and oldest plant, Garlic (Allium sativum L.), cultivated since time immemorial for its use as food and medicine, has many important constituents which requires attention for its many health benefits. It contains sulfur compounds which are responsible for garlic’s medicinal effects and pungent odour. Pharmacological activities such as antimicrobial, antitumor, hypoglycemic and hypolipidemic activities have been reported. Out of the medicinal effects of garlic, one of the main factor or importance of garlic is its potentialities in the treatment of cancer or prevention in cancer development. It contains an important organo sulfur compounds which have been attributed in its impact on inhibition of tumour growth, antioxidant properties and drug metabolizing enzymes. Due to garlic’s valuable medicinal properties, special focus has been made on its cancer prevention and its constituents.
VL  - 4
IS  - 5
ER  -

Copy | Download

Author Information

Thejasenuo Julia Kirha

Department of Botany, Nagaland University, Lumami, Nagaland, India
Tsipila Thonger

Department of Botany, Nagaland University, Lumami, Nagaland, India
Sanjay Kumar

Department of Botany, Nagaland University, Lumami, Nagaland, India

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Thejasenuo Julia Kirha, Tsipila Thonger, Sanjay Kumar. (2017). A Review on the Benefits of Allium sativum on Cancer Prevention. Journal of Cancer Treatment and Research, 4(5), 34-37. https://doi.org/10.11648/j.jctr.20160405.11

Copy | Download

ACS Style

Thejasenuo Julia Kirha; Tsipila Thonger; Sanjay Kumar. A Review on the Benefits of Allium sativum on Cancer Prevention. J. Cancer Treat. Res. 2017, 4(5), 34-37. doi: 10.11648/j.jctr.20160405.11

Copy | Download

AMA Style

Thejasenuo Julia Kirha, Tsipila Thonger, Sanjay Kumar. A Review on the Benefits of Allium sativum on Cancer Prevention. J Cancer Treat Res. 2017;4(5):34-37. doi: 10.11648/j.jctr.20160405.11

Copy | Download

@article{10.11648/j.jctr.20160405.11,
  author = {Thejasenuo Julia Kirha and Tsipila Thonger and Sanjay Kumar},
  title = {A Review on the Benefits of Allium sativum on Cancer Prevention},
  journal = {Journal of Cancer Treatment and Research},
  volume = {4},
  number = {5},
  pages = {34-37},
  doi = {10.11648/j.jctr.20160405.11},
  url = {https://doi.org/10.11648/j.jctr.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20160405.11},
  abstract = {An important and oldest plant, Garlic (Allium sativum L.), cultivated since time immemorial for its use as food and medicine, has many important constituents which requires attention for its many health benefits. It contains sulfur compounds which are responsible for garlic’s medicinal effects and pungent odour. Pharmacological activities such as antimicrobial, antitumor, hypoglycemic and hypolipidemic activities have been reported. Out of the medicinal effects of garlic, one of the main factor or importance of garlic is its potentialities in the treatment of cancer or prevention in cancer development. It contains an important organo sulfur compounds which have been attributed in its impact on inhibition of tumour growth, antioxidant properties and drug metabolizing enzymes. Due to garlic’s valuable medicinal properties, special focus has been made on its cancer prevention and its constituents.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - A Review on the Benefits of Allium sativum on Cancer Prevention
AU  - Thejasenuo Julia Kirha
AU  - Tsipila Thonger
AU  - Sanjay Kumar
Y1  - 2017/03/17
PY  - 2017
N1  - https://doi.org/10.11648/j.jctr.20160405.11
DO  - 10.11648/j.jctr.20160405.11
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20160405.11
AB  - An important and oldest plant, Garlic (Allium sativum L.), cultivated since time immemorial for its use as food and medicine, has many important constituents which requires attention for its many health benefits. It contains sulfur compounds which are responsible for garlic’s medicinal effects and pungent odour. Pharmacological activities such as antimicrobial, antitumor, hypoglycemic and hypolipidemic activities have been reported. Out of the medicinal effects of garlic, one of the main factor or importance of garlic is its potentialities in the treatment of cancer or prevention in cancer development. It contains an important organo sulfur compounds which have been attributed in its impact on inhibition of tumour growth, antioxidant properties and drug metabolizing enzymes. Due to garlic’s valuable medicinal properties, special focus has been made on its cancer prevention and its constituents.
VL  - 4
IS  - 5
ER  -

Copy | Download