Cancer is the second leading cause of mortality and it is a worldwide public health issue and has severe social and economic consequences. Cancer arises through a multistep, mutagenic process whereby cancer cells acquire a common set of properties including unlimited proliferation potential, self-sufficiency in growth signals, and resistance to anti-proliferative and apoptotic signals. Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. Better understanding of the pathogenesis of this disease, identification of molecular targets for therapeutic intervention and availability of promising molecularly targeted therapies may change this dismal picture. These demands lead for developing new effective strategies with focusing on tumor cells and minimum side effects. Targeted cancer therapies have been defined as a new type of emerging treatments. This article provides an overview of: the characteristics and function of signal transduction pathway and emerging RTKs for targeted cancer therapies and therapy targeted at Ras/Raf/MEK/ERK Pathways and PI3k-Akt-mTOR-pathways. Future research in this area will maximize clinical benefit while minimizing the toxicity and cost through utilization of novel targeted agents.
| Published in | Journal of Cancer Treatment and Research (Volume 7, Issue 4) |
| DOI | 10.11648/j.jctr.20190704.11 |
| Page(s) | 69-76 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Cancer, Targeted Therapies, Small Molecule Inhibitors, Monoclonal Antibodies, Ras Pathways
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APA Style
Getu Melesie Taye. (2019). Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy. Journal of Cancer Treatment and Research, 7(4), 69-76. https://doi.org/10.11648/j.jctr.20190704.11
ACS Style
Getu Melesie Taye. Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy. J. Cancer Treat. Res. 2019, 7(4), 69-76. doi: 10.11648/j.jctr.20190704.11
AMA Style
Getu Melesie Taye. Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy. J Cancer Treat Res. 2019;7(4):69-76. doi: 10.11648/j.jctr.20190704.11
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Download@article{10.11648/j.jctr.20190704.11,
author = {Getu Melesie Taye},
title = {Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy},
journal = {Journal of Cancer Treatment and Research},
volume = {7},
number = {4},
pages = {69-76},
doi = {10.11648/j.jctr.20190704.11},
url = {https://doi.org/10.11648/j.jctr.20190704.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20190704.11},
abstract = {Cancer is the second leading cause of mortality and it is a worldwide public health issue and has severe social and economic consequences. Cancer arises through a multistep, mutagenic process whereby cancer cells acquire a common set of properties including unlimited proliferation potential, self-sufficiency in growth signals, and resistance to anti-proliferative and apoptotic signals. Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. Better understanding of the pathogenesis of this disease, identification of molecular targets for therapeutic intervention and availability of promising molecularly targeted therapies may change this dismal picture. These demands lead for developing new effective strategies with focusing on tumor cells and minimum side effects. Targeted cancer therapies have been defined as a new type of emerging treatments. This article provides an overview of: the characteristics and function of signal transduction pathway and emerging RTKs for targeted cancer therapies and therapy targeted at Ras/Raf/MEK/ERK Pathways and PI3k-Akt-mTOR-pathways. Future research in this area will maximize clinical benefit while minimizing the toxicity and cost through utilization of novel targeted agents.},
year = {2019}
}
TY - JOUR T1 - Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy AU - Getu Melesie Taye Y1 - 2019/12/26 PY - 2019 N1 - https://doi.org/10.11648/j.jctr.20190704.11 DO - 10.11648/j.jctr.20190704.11 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 69 EP - 76 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20190704.11 AB - Cancer is the second leading cause of mortality and it is a worldwide public health issue and has severe social and economic consequences. Cancer arises through a multistep, mutagenic process whereby cancer cells acquire a common set of properties including unlimited proliferation potential, self-sufficiency in growth signals, and resistance to anti-proliferative and apoptotic signals. Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. Better understanding of the pathogenesis of this disease, identification of molecular targets for therapeutic intervention and availability of promising molecularly targeted therapies may change this dismal picture. These demands lead for developing new effective strategies with focusing on tumor cells and minimum side effects. Targeted cancer therapies have been defined as a new type of emerging treatments. This article provides an overview of: the characteristics and function of signal transduction pathway and emerging RTKs for targeted cancer therapies and therapy targeted at Ras/Raf/MEK/ERK Pathways and PI3k-Akt-mTOR-pathways. Future research in this area will maximize clinical benefit while minimizing the toxicity and cost through utilization of novel targeted agents. VL - 7 IS - 4 ER -
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