Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors.
| Published in | Journal of Cancer Treatment and Research (Volume 8, Issue 2) |
| DOI | 10.11648/j.jctr.20200802.13 |
| Page(s) | 45-50 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Immunotherapy, Adverse Events, Neoplasms, Immunology
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APA Style
Diana Maslov, Katharine Thomas, Victoria Simenson, Caitlin Sullivan, Alaa Mohammed, et al. (2020). Immunotherapy Related Adverse Events Predict Treatment Response. Journal of Cancer Treatment and Research, 8(2), 45-50. https://doi.org/10.11648/j.jctr.20200802.13
ACS Style
Diana Maslov; Katharine Thomas; Victoria Simenson; Caitlin Sullivan; Alaa Mohammed, et al. Immunotherapy Related Adverse Events Predict Treatment Response. J. Cancer Treat. Res. 2020, 8(2), 45-50. doi: 10.11648/j.jctr.20200802.13
AMA Style
Diana Maslov, Katharine Thomas, Victoria Simenson, Caitlin Sullivan, Alaa Mohammed, et al. Immunotherapy Related Adverse Events Predict Treatment Response. J Cancer Treat Res. 2020;8(2):45-50. doi: 10.11648/j.jctr.20200802.13
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Download@article{10.11648/j.jctr.20200802.13,
author = {Diana Maslov and Katharine Thomas and Victoria Simenson and Caitlin Sullivan and Alaa Mohammed and Jessica Boyce and Marc Matrana},
title = {Immunotherapy Related Adverse Events Predict Treatment Response},
journal = {Journal of Cancer Treatment and Research},
volume = {8},
number = {2},
pages = {45-50},
doi = {10.11648/j.jctr.20200802.13},
url = {https://doi.org/10.11648/j.jctr.20200802.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20200802.13},
abstract = {Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors.},
year = {2020}
}
TY - JOUR T1 - Immunotherapy Related Adverse Events Predict Treatment Response AU - Diana Maslov AU - Katharine Thomas AU - Victoria Simenson AU - Caitlin Sullivan AU - Alaa Mohammed AU - Jessica Boyce AU - Marc Matrana Y1 - 2020/06/09 PY - 2020 N1 - https://doi.org/10.11648/j.jctr.20200802.13 DO - 10.11648/j.jctr.20200802.13 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 45 EP - 50 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20200802.13 AB - Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors. VL - 8 IS - 2 ER -
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