Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review

Katherine Jinghua Lin; Cecile Lengacher; Carmen Rodriguez; Laura Szalacha; Jennifer Wolgemuth

doi:doi:10.11648/j.jctr.20210902.12

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Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review

Katherine Jinghua Lin, Cecile Lengacher, Carmen Rodriguez, Laura Szalacha, Jennifer Wolgemuth

Published in Journal of Cancer Treatment and Research (Volume 9, Issue 2)

Received: 25 May 2021 Accepted: 11 June 2021 Published: 21 June 2021

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Abstract

Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.

Published in	Journal of Cancer Treatment and Research (Volume 9, Issue 2)
DOI	10.11648/j.jctr.20210902.12
Page(s)	27-44
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chemotherapy, Cognitive Dysfunction, Breast Cancer

References

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APA Style

Katherine Jinghua Lin, Cecile Lengacher, Carmen Rodriguez, Laura Szalacha, Jennifer Wolgemuth. (2021). Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. Journal of Cancer Treatment and Research, 9(2), 27-44. https://doi.org/10.11648/j.jctr.20210902.12

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ACS Style

Katherine Jinghua Lin; Cecile Lengacher; Carmen Rodriguez; Laura Szalacha; Jennifer Wolgemuth. Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. J. Cancer Treat. Res. 2021, 9(2), 27-44. doi: 10.11648/j.jctr.20210902.12

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AMA Style

Katherine Jinghua Lin, Cecile Lengacher, Carmen Rodriguez, Laura Szalacha, Jennifer Wolgemuth. Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. J Cancer Treat Res. 2021;9(2):27-44. doi: 10.11648/j.jctr.20210902.12

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@article{10.11648/j.jctr.20210902.12,
  author = {Katherine Jinghua Lin and Cecile Lengacher and Carmen Rodriguez and Laura Szalacha and Jennifer Wolgemuth},
  title = {Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review},
  journal = {Journal of Cancer Treatment and Research},
  volume = {9},
  number = {2},
  pages = {27-44},
  doi = {10.11648/j.jctr.20210902.12},
  url = {https://doi.org/10.11648/j.jctr.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20210902.12},
  abstract = {Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.},
 year = {2021}
}

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TY  - JOUR
T1  - Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review
AU  - Katherine Jinghua Lin
AU  - Cecile Lengacher
AU  - Carmen Rodriguez
AU  - Laura Szalacha
AU  - Jennifer Wolgemuth
Y1  - 2021/06/21
PY  - 2021
N1  - https://doi.org/10.11648/j.jctr.20210902.12
DO  - 10.11648/j.jctr.20210902.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 27
EP  - 44
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20210902.12
AB  - Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.
VL  - 9
IS  - 2
ER  -

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Author Information

Katherine Jinghua Lin

College of Nursing, College of Education, University of South Florida, Tampa, USA
Cecile Lengacher

College of Nursing, College of Education, University of South Florida, Tampa, USA
Carmen Rodriguez

College of Nursing, College of Education, University of South Florida, Tampa, USA
Laura Szalacha

College of Nursing, College of Education, University of South Florida, Tampa, USA
Jennifer Wolgemuth

College of Nursing, College of Education, University of South Florida, Tampa, USA

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APA Style

Katherine Jinghua Lin, Cecile Lengacher, Carmen Rodriguez, Laura Szalacha, Jennifer Wolgemuth. (2021). Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. Journal of Cancer Treatment and Research, 9(2), 27-44. https://doi.org/10.11648/j.jctr.20210902.12

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ACS Style

Katherine Jinghua Lin; Cecile Lengacher; Carmen Rodriguez; Laura Szalacha; Jennifer Wolgemuth. Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. J. Cancer Treat. Res. 2021, 9(2), 27-44. doi: 10.11648/j.jctr.20210902.12

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AMA Style

Katherine Jinghua Lin, Cecile Lengacher, Carmen Rodriguez, Laura Szalacha, Jennifer Wolgemuth. Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review. J Cancer Treat Res. 2021;9(2):27-44. doi: 10.11648/j.jctr.20210902.12

Copy | Download

@article{10.11648/j.jctr.20210902.12,
  author = {Katherine Jinghua Lin and Cecile Lengacher and Carmen Rodriguez and Laura Szalacha and Jennifer Wolgemuth},
  title = {Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review},
  journal = {Journal of Cancer Treatment and Research},
  volume = {9},
  number = {2},
  pages = {27-44},
  doi = {10.11648/j.jctr.20210902.12},
  url = {https://doi.org/10.11648/j.jctr.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20210902.12},
  abstract = {Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Chemotherapy-Related Cognitive Dysfunction in Breast Cancer Survivors: A Systematic Review
AU  - Katherine Jinghua Lin
AU  - Cecile Lengacher
AU  - Carmen Rodriguez
AU  - Laura Szalacha
AU  - Jennifer Wolgemuth
Y1  - 2021/06/21
PY  - 2021
N1  - https://doi.org/10.11648/j.jctr.20210902.12
DO  - 10.11648/j.jctr.20210902.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 27
EP  - 44
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20210902.12
AB  - Objectives: The major aims of this integrative review were to identify: 1) specific cognitive domains affected by chemotherapy; 2) predictors of cognitive dysfunction related to chemotherapy; 3) reported underlying mechanisms of chemotherapy-related cognitive dysfunction, and 4) clinical and research implications of chemotherapy-related cognitive dysfunction (CRCD) among breast cancer survivors. Methods: A computerized search of published research articles through the health journal databases of PubMed, CINAHL, EMBASE, and Web of Science was performed by using the keywords "chemotherapy," "cognitive dysfunction," "cognitive impairment," "cognitive decline," "breast cancer," and "breast carcinoma." References were screened according to inclusion and exclusion criteria. Results: After screening the titles and abstracts of 639 articles, 20 research studies were identified that focused on chemotherapy-related cognitive dysfunction in breast cancer for the final analysis. The 20 studies included: one longitudinal study, eleven prospective studies, two case-control studies, two retrospective studies, and four cross-sectional studies. The analysis of these 20 research studies contributed new knowledge about cognitive domains being affected by chemotherapy, risk factors for CRCD and underlying mechanisms of CRCD. Conclusion: This systematic review indicates significant clinical implications of early assessment and early interventions for CRCD to assist breast cancer survivors.
VL  - 9
IS  - 2
ER  -

Copy | Download