Peroxynitrite (ONOOˉ), a powerful oxidant, is produced by nitric oxide (NO.) and superoxide anion (O2.ˉ). Under the physiological condition, the ONOOˉ could oxidize the lipids, nitrifyproteins, damage DNA and others biomolecules, thereby harm human health. The study used natural products Capsanthin, Myricetin and Capsaicin as the research object and controlled with Vc, and developed the method of HPLC-DAD to separate the components of nitrification damage system, which could determine the inhibition rate of natural products on the formation of 3-nitrotyrosine (3-NT). The fluorescence spectrometry was employed to determine the ability of these substances to inhibit tyrosine dimer and inhibit the self-oxidation of phthalate. The results showed that Capsanthin, Myricetin and Capsaicin had strong inhibitory effect on the generation capacity of 3-NT and tyrosine dimer, and strong inhibitory effect on the self-oxidation of phthalate.
| Published in | Journal of Food and Nutrition Sciences (Volume 5, Issue 5) |
| DOI | 10.11648/j.jfns.20170505.14 |
| Page(s) | 184-191 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
HPLC-UV, Fluorescence Spectrometry, Peroxynitrite, Tyrosine Damage, Flavonoid Pigments, Pyrogallol
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APA Style
Xiaoyu Tang, Anqi Wei, Yan Wang, Yunjing Luo. (2017). Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite. Journal of Food and Nutrition Sciences, 5(5), 184-191. https://doi.org/10.11648/j.jfns.20170505.14
ACS Style
Xiaoyu Tang; Anqi Wei; Yan Wang; Yunjing Luo. Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite. J. Food Nutr. Sci. 2017, 5(5), 184-191. doi: 10.11648/j.jfns.20170505.14
AMA Style
Xiaoyu Tang, Anqi Wei, Yan Wang, Yunjing Luo. Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite. J Food Nutr Sci. 2017;5(5):184-191. doi: 10.11648/j.jfns.20170505.14
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Download@article{10.11648/j.jfns.20170505.14,
author = {Xiaoyu Tang and Anqi Wei and Yan Wang and Yunjing Luo},
title = {Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite},
journal = {Journal of Food and Nutrition Sciences},
volume = {5},
number = {5},
pages = {184-191},
doi = {10.11648/j.jfns.20170505.14},
url = {https://doi.org/10.11648/j.jfns.20170505.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20170505.14},
abstract = {Peroxynitrite (ONOOˉ), a powerful oxidant, is produced by nitric oxide (NO.) and superoxide anion (O2.ˉ). Under the physiological condition, the ONOOˉ could oxidize the lipids, nitrifyproteins, damage DNA and others biomolecules, thereby harm human health. The study used natural products Capsanthin, Myricetin and Capsaicin as the research object and controlled with Vc, and developed the method of HPLC-DAD to separate the components of nitrification damage system, which could determine the inhibition rate of natural products on the formation of 3-nitrotyrosine (3-NT). The fluorescence spectrometry was employed to determine the ability of these substances to inhibit tyrosine dimer and inhibit the self-oxidation of phthalate. The results showed that Capsanthin, Myricetin and Capsaicin had strong inhibitory effect on the generation capacity of 3-NT and tyrosine dimer, and strong inhibitory effect on the self-oxidation of phthalate.},
year = {2017}
}
TY - JOUR T1 - Study on the Effect of Several Natural Products on Tyrosine Damage Induced by Peroxynitrite AU - Xiaoyu Tang AU - Anqi Wei AU - Yan Wang AU - Yunjing Luo Y1 - 2017/08/07 PY - 2017 N1 - https://doi.org/10.11648/j.jfns.20170505.14 DO - 10.11648/j.jfns.20170505.14 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 184 EP - 191 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20170505.14 AB - Peroxynitrite (ONOOˉ), a powerful oxidant, is produced by nitric oxide (NO.) and superoxide anion (O2.ˉ). Under the physiological condition, the ONOOˉ could oxidize the lipids, nitrifyproteins, damage DNA and others biomolecules, thereby harm human health. The study used natural products Capsanthin, Myricetin and Capsaicin as the research object and controlled with Vc, and developed the method of HPLC-DAD to separate the components of nitrification damage system, which could determine the inhibition rate of natural products on the formation of 3-nitrotyrosine (3-NT). The fluorescence spectrometry was employed to determine the ability of these substances to inhibit tyrosine dimer and inhibit the self-oxidation of phthalate. The results showed that Capsanthin, Myricetin and Capsaicin had strong inhibitory effect on the generation capacity of 3-NT and tyrosine dimer, and strong inhibitory effect on the self-oxidation of phthalate. VL - 5 IS - 5 ER -
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