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Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review

Received: 1 November 2021    Accepted: 6 December 2021    Published: 31 December 2021
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Abstract

Background: The ossification of ligamentum flavum occurs frequently in the thoracic vertebra, and the incidence of ossification of cervical ligamentum flavum is relatively low. It is easy to cause misdiagnosis and mistreatment due to lack of understanding in clinical practice. Object: To understand the diagnosis and treatment of cervical ossification of ligamentum flavum through the treatment of one case. Material: A 65-year-old female patient was hospitalized due to "lumbar discomfort with numbness of both lower limbs for 1 year, and aggravation with numbness and weakness of both upper limbs for the last 3 months". Physical examination showed cervical flexion, extension and lateral flexion activities were limited, post extension limitations were obvious, limb muscle strength was grade 4, right knee tendon reflex was active, and bilateral Hoffman sign and right Babinski sign were positive. Cervical JOA score was 8 points. Magnetic resonance imaging of cervical spine showed that there were pressure objects protruding to the spinal canal between C3/4, C5/6, and C6/7 laminae. Sagittal MRI showed segmental or focal nodular space occupying and protruding into the spinal canal from the rear of the spinal canal. Cross sectional MRI showed nodular or "M" shaped occupying space. T1 weighted image was equal signal, and T2 weighted image showed low signal shadow, suggesting high-density ossification and severe spinal cord compression. The effective sagittal diameter was less than 8mm. Method: Hemilaminectomy was performed for a single segmental OLF of C3/4, and a total laminectomy was performed for bilateral and multi-segmental OLF of C5/6, 6/7. According to the range of intraoperative decompression, C5 and 6 posterior lateral mass screws and C7 pedicle screws were fixed. Result: After the operation, the patient indicated that his upper limbs were relaxed, the umbilical horizontal band disappeared, and the muscle strength of his limbs was stronger than that before the operation. She could move freely on the ground, and her holding was more flexible and powerful than before. The postoperative JOA score was 12 points. The postoperative pathological result was fibrous connective tissue and ossification. The follow-up JOA score was increased to 15 points 8 months after operation, and the improvement rate was 78%. The patient could completely take care of herself, and the treatment was satisfactory. Conclusion: Surgical resection of cervical olf and canal decompression is an effective method for the treatment of Cervical OLF and can achieve good clinical results.

Published in Journal of Surgery (Volume 9, Issue 6)
DOI 10.11648/j.js.20210906.16
Page(s) 282-286
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cervical Vertebrae, Ligamentum Flavum, Ossification, Heterotopic

References
[1] Ohara Y. Ossification of the ligaments in the cervical spine, including ossification of the anterior longitudinal ligament, ossification of the posterior longitudinal ligament, and ossification of the ligamentum flavum [J]. Neurosurg Clin N Am, 2018, 29 (1): 63-68.
[2] Li huiqing, Xing feng, Wu desheng, et al. Diagnosis and treatment of ossification of cervical ligamentum flavum [J]. Shanghai Preventive Medicine, 2011, 23 (3): 138-139.
[3] Takahashi T, Hanakita J, Minami M. Pathophysiology of calcification and ossification of the ligamentum flavum in the cervical spine [J]. Neurosurg Clin N Am, 2018, 29 (1): 47-54.
[4] Feng liangen, Zhou rongping, Gu yurong, et al. Cervical ossification of ligamentum flavum combined with ossification of posterior longitudinal ligament was treated by stages [J]. Journal of Practical Orthopedics, 2014, 20 (11): 961-964.
[5] Jiang zhensong, Zhang zuolun, Liu lichneg, et al. Cervical CT measurement in patients with cervical spondylotic myelopathy and its clinical significance [J]. Chinese Journal of Spinal cord, 2003 (4): 29-32.
[6] Fukui M, Chiba K, Kawakami M, et al. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 2. Endorsement of the alternative item [J]. J Orthop Sci, 2007, 12 (3): 241-248.
[7] Feng FB, Sun CG, Chen ZQ. Progress on clinical characteristics and identification of location of thoracic ossification of the ligamentum flavum [J]. Orthop Surg, 2015, 7 (2): 87-96.
[8] Tetreault L, Goldstein CL, Arnold P, et al. Degenerative cervical myelopathy: a spectrum of related disorders affecting the aging spine [J]. Neurosurgery, 2015, 77 (Suppl 4): S51-67.
[9] Liu zhongjun, Cai qinlin, Dang gengting, et al. Ossification and calcification of the ligamentum flavum of the cervical spine [J]. Chinese Journal of Spinal cord, 1996, (2): 11-13.
[10] Song JY, Park JH, Roh SW. Ossified Ligamentum Flavum causing Cervical Myelopathy [J]. Korean J Spine, 2012, 9 (1): 24-27.
[11] Jia lianshun, Shi jiangang. Pay attention to the diagnosis and strict operation indication of cervical spondylotic myelopathy [J]. Chinese Journal of Orthopaedics, 2002, 22 (1): 58-60.
[12] Kotani Y, Takahata M, Abumi K, et al. Cervical myelopathy resulting from combined ossification of the ligamentum flavum and posterior longitudinal ligament: report of two cases and literature review [J]. Spine J, 2013, 13 (1): e1-e6.
[13] Paiva WS, Soares MS, Bernardo LS, et al. Cervical myelopathy caused by ligamentum flavum ossification [J]. Arq Neuropsiquiatr, 2012, 70 (1): 71-72.
[14] Sonntag VK. Ossification of the ligamentum flavum (OLF): an increasing cause of cervical myelopathy [J]. World Neurosurg, 2011, 75 (3-4): 445-446.
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    Ding Ming, Li Chao. (2021). Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review. Journal of Surgery, 9(6), 282-286. https://doi.org/10.11648/j.js.20210906.16

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    ACS Style

    Ding Ming; Li Chao. Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review. J. Surg. 2021, 9(6), 282-286. doi: 10.11648/j.js.20210906.16

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    AMA Style

    Ding Ming, Li Chao. Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review. J Surg. 2021;9(6):282-286. doi: 10.11648/j.js.20210906.16

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  • @article{10.11648/j.js.20210906.16,
      author = {Ding Ming and Li Chao},
      title = {Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review},
      journal = {Journal of Surgery},
      volume = {9},
      number = {6},
      pages = {282-286},
      doi = {10.11648/j.js.20210906.16},
      url = {https://doi.org/10.11648/j.js.20210906.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20210906.16},
      abstract = {Background: The ossification of ligamentum flavum occurs frequently in the thoracic vertebra, and the incidence of ossification of cervical ligamentum flavum is relatively low. It is easy to cause misdiagnosis and mistreatment due to lack of understanding in clinical practice. Object: To understand the diagnosis and treatment of cervical ossification of ligamentum flavum through the treatment of one case. Material: A 65-year-old female patient was hospitalized due to "lumbar discomfort with numbness of both lower limbs for 1 year, and aggravation with numbness and weakness of both upper limbs for the last 3 months". Physical examination showed cervical flexion, extension and lateral flexion activities were limited, post extension limitations were obvious, limb muscle strength was grade 4, right knee tendon reflex was active, and bilateral Hoffman sign and right Babinski sign were positive. Cervical JOA score was 8 points. Magnetic resonance imaging of cervical spine showed that there were pressure objects protruding to the spinal canal between C3/4, C5/6, and C6/7 laminae. Sagittal MRI showed segmental or focal nodular space occupying and protruding into the spinal canal from the rear of the spinal canal. Cross sectional MRI showed nodular or "M" shaped occupying space. T1 weighted image was equal signal, and T2 weighted image showed low signal shadow, suggesting high-density ossification and severe spinal cord compression. The effective sagittal diameter was less than 8mm. Method: Hemilaminectomy was performed for a single segmental OLF of C3/4, and a total laminectomy was performed for bilateral and multi-segmental OLF of C5/6, 6/7. According to the range of intraoperative decompression, C5 and 6 posterior lateral mass screws and C7 pedicle screws were fixed. Result: After the operation, the patient indicated that his upper limbs were relaxed, the umbilical horizontal band disappeared, and the muscle strength of his limbs was stronger than that before the operation. She could move freely on the ground, and her holding was more flexible and powerful than before. The postoperative JOA score was 12 points. The postoperative pathological result was fibrous connective tissue and ossification. The follow-up JOA score was increased to 15 points 8 months after operation, and the improvement rate was 78%. The patient could completely take care of herself, and the treatment was satisfactory. Conclusion: Surgical resection of cervical olf and canal decompression is an effective method for the treatment of Cervical OLF and can achieve good clinical results.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Treatment of a Patient with Ossification of Ligamentum Flavum of Cervical Spine and Literature Review
    AU  - Ding Ming
    AU  - Li Chao
    Y1  - 2021/12/31
    PY  - 2021
    N1  - https://doi.org/10.11648/j.js.20210906.16
    DO  - 10.11648/j.js.20210906.16
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 282
    EP  - 286
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20210906.16
    AB  - Background: The ossification of ligamentum flavum occurs frequently in the thoracic vertebra, and the incidence of ossification of cervical ligamentum flavum is relatively low. It is easy to cause misdiagnosis and mistreatment due to lack of understanding in clinical practice. Object: To understand the diagnosis and treatment of cervical ossification of ligamentum flavum through the treatment of one case. Material: A 65-year-old female patient was hospitalized due to "lumbar discomfort with numbness of both lower limbs for 1 year, and aggravation with numbness and weakness of both upper limbs for the last 3 months". Physical examination showed cervical flexion, extension and lateral flexion activities were limited, post extension limitations were obvious, limb muscle strength was grade 4, right knee tendon reflex was active, and bilateral Hoffman sign and right Babinski sign were positive. Cervical JOA score was 8 points. Magnetic resonance imaging of cervical spine showed that there were pressure objects protruding to the spinal canal between C3/4, C5/6, and C6/7 laminae. Sagittal MRI showed segmental or focal nodular space occupying and protruding into the spinal canal from the rear of the spinal canal. Cross sectional MRI showed nodular or "M" shaped occupying space. T1 weighted image was equal signal, and T2 weighted image showed low signal shadow, suggesting high-density ossification and severe spinal cord compression. The effective sagittal diameter was less than 8mm. Method: Hemilaminectomy was performed for a single segmental OLF of C3/4, and a total laminectomy was performed for bilateral and multi-segmental OLF of C5/6, 6/7. According to the range of intraoperative decompression, C5 and 6 posterior lateral mass screws and C7 pedicle screws were fixed. Result: After the operation, the patient indicated that his upper limbs were relaxed, the umbilical horizontal band disappeared, and the muscle strength of his limbs was stronger than that before the operation. She could move freely on the ground, and her holding was more flexible and powerful than before. The postoperative JOA score was 12 points. The postoperative pathological result was fibrous connective tissue and ossification. The follow-up JOA score was increased to 15 points 8 months after operation, and the improvement rate was 78%. The patient could completely take care of herself, and the treatment was satisfactory. Conclusion: Surgical resection of cervical olf and canal decompression is an effective method for the treatment of Cervical OLF and can achieve good clinical results.
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Department of Orthopedics, Affiliated Hospital of Qingdao Binhai University, Qingdao, China

  • Department of Orthopedics, Affiliated Hospital of Qingdao Binhai University, Qingdao, China

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