Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis

Sarah Hobelsberger; Fabian Lohaus; Steffen Löck; Henriette Rönsch; Julia Brütting; Friedegund Meier; Stefan Beissert; Jörg Laske

doi:doi:10.11648/j.js.20221002.13

Research Article |

Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis

Sarah Hobelsberger, Fabian Lohaus, Steffen Löck, Henriette Rönsch, Julia Brütting, Friedegund Meier, Stefan Beissert, Jörg Laske

Published in Journal of Surgery (Volume 10, Issue 2)

Received: 14 February 2022 Accepted: 3 March 2022 Published: 11 March 2022

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Abstract

In the treatment of highly malignant skin tumors postoperative radiotherapy may be indicated after wound closure. In the University Hospital Carl Gustav Carus Dresden, Germany, a retrospective study of 75 patients, who received postoperative radiotherapy after wound closure, was conducted. In all 75 patients (56 male, 19 female), radical doses of irradiation (40-70 Gy in 20–35 fractions) were administered. The median time interval between surgery and radiation therapy was 7 weeks (range 3-48 weeks). The incidence of wound healing complications (WHCs) increased after radiotherapy (p<0.001). Univariable analysis showed that WHCs were associated with immunosuppression (p=0.002), split thickness skin graft (p=0.007) lymphoma or leukemia (p=0.032) and diabetes mellitus (p=0.046). Multivariable logistic regression showed that independent risk factors for WHCs were split thickness skin transplantation (odds ratio: 3.85, 95% confidence interval (CI): 1.13–13.1, p=0.031) and immunosuppression (odds ratio: 4.69, 95% CI: 1.18–18.7, p=0.029). The authors observed no association between surgical site infections and WHCs (p=1.0). Univariable analysis showed that SSIs were associated with leukemia or lymphoma (p=0.019). Together, the results show an increased incidence of WHCs after radiotherapy. Other conditions associated with WHCs were leukemia or lymphoma and diabetes mellitus. Immunosuppression and split thickness skin transplantation were independent risk factors for WHCs.

Published in	Journal of Surgery (Volume 10, Issue 2)
DOI	10.11648/j.js.20221002.13
Page(s)	67-74
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Non-melanoma Skin Cancer, Wound Healing Complications, Adjuvant Radiotherapy, Wound Closure Techniques, Diabetes Complications, Retrospective Studies

References

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APA Style

Hobelsberger, S., Lohaus, F., Löck, S., Rönsch, H., Brütting, J., et al. (2022). Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. Journal of Surgery, 10(2), 67-74. https://doi.org/10.11648/j.js.20221002.13

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ACS Style

Hobelsberger, S.; Lohaus, F.; Löck, S.; Rönsch, H.; Brütting, J., et al. Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. J. Surg. 2022, 10(2), 67-74. doi: 10.11648/j.js.20221002.13

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AMA Style

Hobelsberger S, Lohaus F, Löck S, Rönsch H, Brütting J, et al. Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. J Surg. 2022;10(2):67-74. doi: 10.11648/j.js.20221002.13

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@article{10.11648/j.js.20221002.13,
  author = {Sarah Hobelsberger and Fabian Lohaus and Steffen Löck and Henriette Rönsch and Julia Brütting and Friedegund Meier and Stefan Beissert and Jörg Laske},
  title = {Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis},
  journal = {Journal of Surgery},
  volume = {10},
  number = {2},
  pages = {67-74},
  doi = {10.11648/j.js.20221002.13},
  url = {https://doi.org/10.11648/j.js.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221002.13},
  abstract = {In the treatment of highly malignant skin tumors postoperative radiotherapy may be indicated after wound closure. In the University Hospital Carl Gustav Carus Dresden, Germany, a retrospective study of 75 patients, who received postoperative radiotherapy after wound closure, was conducted. In all 75 patients (56 male, 19 female), radical doses of irradiation (40-70 Gy in 20–35 fractions) were administered. The median time interval between surgery and radiation therapy was 7 weeks (range 3-48 weeks). The incidence of wound healing complications (WHCs) increased after radiotherapy (p<0.001). Univariable analysis showed that WHCs were associated with immunosuppression (p=0.002), split thickness skin graft (p=0.007) lymphoma or leukemia (p=0.032) and diabetes mellitus (p=0.046). Multivariable logistic regression showed that independent risk factors for WHCs were split thickness skin transplantation (odds ratio: 3.85, 95% confidence interval (CI): 1.13–13.1, p=0.031) and immunosuppression (odds ratio: 4.69, 95% CI: 1.18–18.7, p=0.029). The authors observed no association between surgical site infections and WHCs (p=1.0). Univariable analysis showed that SSIs were associated with leukemia or lymphoma (p=0.019). Together, the results show an increased incidence of WHCs after radiotherapy. Other conditions associated with WHCs were leukemia or lymphoma and diabetes mellitus. Immunosuppression and split thickness skin transplantation were independent risk factors for WHCs.},
 year = {2022}
}

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TY  - JOUR
T1  - Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis
AU  - Sarah Hobelsberger
AU  - Fabian Lohaus
AU  - Steffen Löck
AU  - Henriette Rönsch
AU  - Julia Brütting
AU  - Friedegund Meier
AU  - Stefan Beissert
AU  - Jörg Laske
Y1  - 2022/03/11
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221002.13
DO  - 10.11648/j.js.20221002.13
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 67
EP  - 74
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221002.13
AB  - In the treatment of highly malignant skin tumors postoperative radiotherapy may be indicated after wound closure. In the University Hospital Carl Gustav Carus Dresden, Germany, a retrospective study of 75 patients, who received postoperative radiotherapy after wound closure, was conducted. In all 75 patients (56 male, 19 female), radical doses of irradiation (40-70 Gy in 20–35 fractions) were administered. The median time interval between surgery and radiation therapy was 7 weeks (range 3-48 weeks). The incidence of wound healing complications (WHCs) increased after radiotherapy (p<0.001). Univariable analysis showed that WHCs were associated with immunosuppression (p=0.002), split thickness skin graft (p=0.007) lymphoma or leukemia (p=0.032) and diabetes mellitus (p=0.046). Multivariable logistic regression showed that independent risk factors for WHCs were split thickness skin transplantation (odds ratio: 3.85, 95% confidence interval (CI): 1.13–13.1, p=0.031) and immunosuppression (odds ratio: 4.69, 95% CI: 1.18–18.7, p=0.029). The authors observed no association between surgical site infections and WHCs (p=1.0). Univariable analysis showed that SSIs were associated with leukemia or lymphoma (p=0.019). Together, the results show an increased incidence of WHCs after radiotherapy. Other conditions associated with WHCs were leukemia or lymphoma and diabetes mellitus. Immunosuppression and split thickness skin transplantation were independent risk factors for WHCs.
VL  - 10
IS  - 2
ER  -

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Author Information

Sarah Hobelsberger

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Fabian Lohaus

Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Steffen Löck

OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Henriette Rönsch

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Julia Brütting

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Friedegund Meier

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Stefan Beissert

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Jörg Laske

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Plain Text BibTeX RIS

APA Style

Hobelsberger, S., Lohaus, F., Löck, S., Rönsch, H., Brütting, J., et al. (2022). Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. Journal of Surgery, 10(2), 67-74. https://doi.org/10.11648/j.js.20221002.13

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ACS Style

Hobelsberger, S.; Lohaus, F.; Löck, S.; Rönsch, H.; Brütting, J., et al. Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. J. Surg. 2022, 10(2), 67-74. doi: 10.11648/j.js.20221002.13

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AMA Style

Hobelsberger S, Lohaus F, Löck S, Rönsch H, Brütting J, et al. Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis. J Surg. 2022;10(2):67-74. doi: 10.11648/j.js.20221002.13

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@article{10.11648/j.js.20221002.13,
  author = {Sarah Hobelsberger and Fabian Lohaus and Steffen Löck and Henriette Rönsch and Julia Brütting and Friedegund Meier and Stefan Beissert and Jörg Laske},
  title = {Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis},
  journal = {Journal of Surgery},
  volume = {10},
  number = {2},
  pages = {67-74},
  doi = {10.11648/j.js.20221002.13},
  url = {https://doi.org/10.11648/j.js.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221002.13},
  abstract = {In the treatment of highly malignant skin tumors postoperative radiotherapy may be indicated after wound closure. In the University Hospital Carl Gustav Carus Dresden, Germany, a retrospective study of 75 patients, who received postoperative radiotherapy after wound closure, was conducted. In all 75 patients (56 male, 19 female), radical doses of irradiation (40-70 Gy in 20–35 fractions) were administered. The median time interval between surgery and radiation therapy was 7 weeks (range 3-48 weeks). The incidence of wound healing complications (WHCs) increased after radiotherapy (p<0.001). Univariable analysis showed that WHCs were associated with immunosuppression (p=0.002), split thickness skin graft (p=0.007) lymphoma or leukemia (p=0.032) and diabetes mellitus (p=0.046). Multivariable logistic regression showed that independent risk factors for WHCs were split thickness skin transplantation (odds ratio: 3.85, 95% confidence interval (CI): 1.13–13.1, p=0.031) and immunosuppression (odds ratio: 4.69, 95% CI: 1.18–18.7, p=0.029). The authors observed no association between surgical site infections and WHCs (p=1.0). Univariable analysis showed that SSIs were associated with leukemia or lymphoma (p=0.019). Together, the results show an increased incidence of WHCs after radiotherapy. Other conditions associated with WHCs were leukemia or lymphoma and diabetes mellitus. Immunosuppression and split thickness skin transplantation were independent risk factors for WHCs.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Conditions Associated with Wound Healing Complications After Adjuvant Radiotherapy in Patients with Non-Melanoma Skin Cancer: A Retrospective Analysis
AU  - Sarah Hobelsberger
AU  - Fabian Lohaus
AU  - Steffen Löck
AU  - Henriette Rönsch
AU  - Julia Brütting
AU  - Friedegund Meier
AU  - Stefan Beissert
AU  - Jörg Laske
Y1  - 2022/03/11
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221002.13
DO  - 10.11648/j.js.20221002.13
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 67
EP  - 74
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221002.13
AB  - In the treatment of highly malignant skin tumors postoperative radiotherapy may be indicated after wound closure. In the University Hospital Carl Gustav Carus Dresden, Germany, a retrospective study of 75 patients, who received postoperative radiotherapy after wound closure, was conducted. In all 75 patients (56 male, 19 female), radical doses of irradiation (40-70 Gy in 20–35 fractions) were administered. The median time interval between surgery and radiation therapy was 7 weeks (range 3-48 weeks). The incidence of wound healing complications (WHCs) increased after radiotherapy (p<0.001). Univariable analysis showed that WHCs were associated with immunosuppression (p=0.002), split thickness skin graft (p=0.007) lymphoma or leukemia (p=0.032) and diabetes mellitus (p=0.046). Multivariable logistic regression showed that independent risk factors for WHCs were split thickness skin transplantation (odds ratio: 3.85, 95% confidence interval (CI): 1.13–13.1, p=0.031) and immunosuppression (odds ratio: 4.69, 95% CI: 1.18–18.7, p=0.029). The authors observed no association between surgical site infections and WHCs (p=1.0). Univariable analysis showed that SSIs were associated with leukemia or lymphoma (p=0.019). Together, the results show an increased incidence of WHCs after radiotherapy. Other conditions associated with WHCs were leukemia or lymphoma and diabetes mellitus. Immunosuppression and split thickness skin transplantation were independent risk factors for WHCs.
VL  - 10
IS  - 2
ER  -

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