Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P < 0.0001), with higher positive expression in squamous cell carcinoma group; TTF-1 was almost not expressed in mediastinal lymph node metastasis from lung squamous cell carcinoma group, so it can effectively distinguish and exclude lymph node metastasis from lung squamous cell carcinoma; Napsin A and CK7 could effectively identify lymph node metastasis from lung adenocarcinoma; Syn, TTF-1, CD56 and CgA were significantly different in lymph node metastasis from small cell lung cancer, of which Syn was the most sensitive (positive expression rate was 90%). Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis.
| Published in | Journal of Surgery (Volume 10, Issue 3) |
| DOI | 10.11648/j.js.20221003.17 |
| Page(s) | 125-130 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA), Lung Cancer, Mediastinal Lymph Node Metastasis, Pathologic Diagnosis, Pathological Classification, Immunohistochemistry
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APA Style
Zhao Congxuan, Yu Tao. (2022). Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA. Journal of Surgery, 10(3), 125-130. https://doi.org/10.11648/j.js.20221003.17
ACS Style
Zhao Congxuan; Yu Tao. Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA. J. Surg. 2022, 10(3), 125-130. doi: 10.11648/j.js.20221003.17
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Download@article{10.11648/j.js.20221003.17,
author = {Zhao Congxuan and Yu Tao},
title = {Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA},
journal = {Journal of Surgery},
volume = {10},
number = {3},
pages = {125-130},
doi = {10.11648/j.js.20221003.17},
url = {https://doi.org/10.11648/j.js.20221003.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221003.17},
abstract = {Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis.},
year = {2022}
}
TY - JOUR T1 - Immunohistochemical Analysis of Mediastinal Lymph Node Metastasis of Lung Cancer by EBUS-TBNA AU - Zhao Congxuan AU - Yu Tao Y1 - 2022/06/09 PY - 2022 N1 - https://doi.org/10.11648/j.js.20221003.17 DO - 10.11648/j.js.20221003.17 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 125 EP - 130 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20221003.17 AB - Objective: To analyze the immunohistochemical characteristics of mediastinal lymph node metastasis of lung cancer, and compare the positive expression of immunohistochemical markers in the main pathological types of lung cancer. Materials and Methods: From January 2015 to March 2019, 142 patients who underwent EBUS-TBNA examination in Cancer Hospital Affiliated to China Medical University due to hilar and mediastinal lymphadenopathy on CT were analyzed retrospectively. The pathological and immunohistochemical results of these patients were statistically analyzed. Results: P63 and CK5 / 6 were significantly expressed in lymph node metastasis from lung squamous cell carcinoma; CK8 / 18 was only statistically different between small cell lung cancer group and squamous cell carcinoma group (P Conclusions: Immunohistochemistry can improve the accuracy of EBUS-TBNA in the diagnosis of lung cancer with lymph node metastasis, and is conducive to the accurate classification of lung cancer with mediastinal lymph node metastasis. VL - 10 IS - 3 ER -
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