The Non-Ossifying Fibroma: A Case Report and Review of the Literature

Shengjie Sun; Weixiong Ye; Yangyang Xu; Zhencheng Feng; Qingqi Meng

doi:doi:10.11648/j.js.20221004.12

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The Non-Ossifying Fibroma: A Case Report and Review of the Literature

Shengjie Sun, Weixiong Ye, Yangyang Xu, Zhencheng Feng, Qingqi Meng

Published in Journal of Surgery (Volume 10, Issue 4)

Received: 31 August 2022 Accepted: 12 September 2022 Published: 27 September 2022

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Abstract

Nonossifying fibroma is a benign tumor lesion commonly seen in children that is characterized by spontaneous regression and is usually located in the cortex of long bones, but cases occurring in other bone tissues have also been reported. It is usually not accompanied by clinical manifestations such as pain and dysfunction of the affected limb throughout the course of the disease, and the shape of the same affected limb is not significantly changed, usually found by imaging examination after injury. In this paper, we report a 12-year-old male patient who was admitted to our hospital with left lower leg pain caused by a fall during running. Emergency radiography of the left leg showed cystic swelling lesion in the cortex at the anterior edge of the left tibial metaphysis, aneurysmal bone cyst? non-ossifying fibroma? Relevant preoperative examinations were perfected after admission, and through adequate preoperative planning and discussion, it was decided to perform debridement and bone grafting of the left lower tibial tumor lesion. After operation, the function of left lower limb recovered well after professional rehabilitation training, and the therapeutic effect was satisfactory. When imaging studies after injury suspect uncured fibroma or pathological fractures, debridement and bone grafting of the lesion is necessary to prevent further aggravation of the fracture.

Published in	Journal of Surgery (Volume 10, Issue 4)
DOI	10.11648/j.js.20221004.12
Page(s)	140-143
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Non Ossifying Fibroma, Children Bone Tumour, Pediatrics, Surgical Treatment, Unusual Presentation

References

[1]	Baumhoer D, Rogozhin D. WHO Classification of Tumours of Soft Tissue and Bone. 5: Lyon: IARC Press, 2020.
[2]	Nielsen G P, Kyriakos M. Non-ossifying fibroma/benign fibrous histiocytoma of bone [J], 2013.
[3]	Mankin H J, Trahan C A, Fondren G, et al. Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review [J]. La Chirurgia Degli Organi Di Movimento, 2009, 93 (1): 1-7.
[4]	Sontag L W, Pyle S I. The appearance and nature of cyst-like areas in the distal femoral metaphysis of children [J]. American Journal of Roentgenology, 1941, 46: 185-188.
[5]	Chrcanovic B R, Albanese A L, Freire-Maia B, et al. Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible [J]. Oral and maxillofacial surgery, 2011, 15 (4): 233-237.
[6]	Weiss S, Bridge J. World Health Organization Classification of Tumours, Pathology & Genetics Tumours of Soft Tissue and Bone: IARC Press, Lyon, 2002.
[7]	Dahlin D. Fibroma (nonosteogenic fibroma of bone, metaphyseal fibrous defect), myxoma, cortical desmoid, fibromatosis, and “anthoma”[J]. Bone tumors. general aspects and data on, 1978, 6: 122-36.
[8]	Klein M H, Rosenberg Z S, Lehman W. Nonossifying fibroma of bone: a case report [J]. Bulletin of the Hospital for Joint Diseases Orthopaedic Institute, 1990, 50 (1): 64-69.
[9]	Betsy M, Kupersmith L M, Springfield D S. Metaphyseal fibrous defects [J]. The Journal of the American Academy of Orthopaedic Surgeons, 2004, 12 (2): 89-95.
[10]	Mirra J M. Fibrohistiocytic tumors of intramedullary origin [J], 1989.
[11]	Cleven A H G, Schreuder W H, Groen E, et al. Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours [J]. Virchows Archiv: an International Journal of Pathology, 2022.
[12]	Baumhoer D, Kovac M, Sperveslage J, et al. Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone [J]. The Journal of Pathology, 2019, 248 (1): 116-122.
[13]	Kuznetsov S A, Cherman N, Riminucci M, et al. Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone [J]. Journal of Bone and Mineral Research: the Official Journal of the American Society For Bone and Mineral Research, 2008, 23 (11): 1731-1740.
[14]	Blau R A, Zwick D L, Westphal R A. Multiple non-ossifying fibromas. A case report [J]. Journal of Bone & Joint Surgery American Volume, 1988, 70 (2): 299-304.
[15]	Mizukawa N, Nishijima Y, Nishijima K. Metaphyseal fibrous defect (nonossifying fibroma) in the mandible. A case report [J]. International Journal of Oral & Maxillofacial Surgery, 1997, 26 (2): 129.
[16]	Canavese F, Samba A, Rousset M. Pathological fractures in children: Diagnosis and treatment options [J]. Orthopaedics & Traumatology, Surgery & Research: OTSR, 2016, 102 (1 Suppl): S149-S159.
[17]	Cherix S, Bildé Y, Becce F, et al. Multiple non-ossifying fibromas as a cause of pathological femoral fracture in Jaffe-Campanacci syndrome [J]. BMC Musculoskeletal Disorders, 2014, 15: 218.

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APA Style

Shengjie Sun, Weixiong Ye, Yangyang Xu, Zhencheng Feng, Qingqi Meng. (2022). The Non-Ossifying Fibroma: A Case Report and Review of the Literature. Journal of Surgery, 10(4), 140-143. https://doi.org/10.11648/j.js.20221004.12

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ACS Style

Shengjie Sun; Weixiong Ye; Yangyang Xu; Zhencheng Feng; Qingqi Meng. The Non-Ossifying Fibroma: A Case Report and Review of the Literature. J. Surg. 2022, 10(4), 140-143. doi: 10.11648/j.js.20221004.12

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AMA Style

Shengjie Sun, Weixiong Ye, Yangyang Xu, Zhencheng Feng, Qingqi Meng. The Non-Ossifying Fibroma: A Case Report and Review of the Literature. J Surg. 2022;10(4):140-143. doi: 10.11648/j.js.20221004.12

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@article{10.11648/j.js.20221004.12,
  author = {Shengjie Sun and Weixiong Ye and Yangyang Xu and Zhencheng Feng and Qingqi Meng},
  title = {The Non-Ossifying Fibroma: A Case Report and Review of the Literature},
  journal = {Journal of Surgery},
  volume = {10},
  number = {4},
  pages = {140-143},
  doi = {10.11648/j.js.20221004.12},
  url = {https://doi.org/10.11648/j.js.20221004.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221004.12},
  abstract = {Nonossifying fibroma is a benign tumor lesion commonly seen in children that is characterized by spontaneous regression and is usually located in the cortex of long bones, but cases occurring in other bone tissues have also been reported. It is usually not accompanied by clinical manifestations such as pain and dysfunction of the affected limb throughout the course of the disease, and the shape of the same affected limb is not significantly changed, usually found by imaging examination after injury. In this paper, we report a 12-year-old male patient who was admitted to our hospital with left lower leg pain caused by a fall during running. Emergency radiography of the left leg showed cystic swelling lesion in the cortex at the anterior edge of the left tibial metaphysis, aneurysmal bone cyst? non-ossifying fibroma? Relevant preoperative examinations were perfected after admission, and through adequate preoperative planning and discussion, it was decided to perform debridement and bone grafting of the left lower tibial tumor lesion. After operation, the function of left lower limb recovered well after professional rehabilitation training, and the therapeutic effect was satisfactory. When imaging studies after injury suspect uncured fibroma or pathological fractures, debridement and bone grafting of the lesion is necessary to prevent further aggravation of the fracture.},
 year = {2022}
}

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TY  - JOUR
T1  - The Non-Ossifying Fibroma: A Case Report and Review of the Literature
AU  - Shengjie Sun
AU  - Weixiong Ye
AU  - Yangyang Xu
AU  - Zhencheng Feng
AU  - Qingqi Meng
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221004.12
DO  - 10.11648/j.js.20221004.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 140
EP  - 143
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221004.12
AB  - Nonossifying fibroma is a benign tumor lesion commonly seen in children that is characterized by spontaneous regression and is usually located in the cortex of long bones, but cases occurring in other bone tissues have also been reported. It is usually not accompanied by clinical manifestations such as pain and dysfunction of the affected limb throughout the course of the disease, and the shape of the same affected limb is not significantly changed, usually found by imaging examination after injury. In this paper, we report a 12-year-old male patient who was admitted to our hospital with left lower leg pain caused by a fall during running. Emergency radiography of the left leg showed cystic swelling lesion in the cortex at the anterior edge of the left tibial metaphysis, aneurysmal bone cyst? non-ossifying fibroma? Relevant preoperative examinations were perfected after admission, and through adequate preoperative planning and discussion, it was decided to perform debridement and bone grafting of the left lower tibial tumor lesion. After operation, the function of left lower limb recovered well after professional rehabilitation training, and the therapeutic effect was satisfactory. When imaging studies after injury suspect uncured fibroma or pathological fractures, debridement and bone grafting of the lesion is necessary to prevent further aggravation of the fracture.
VL  - 10
IS  - 4
ER  -

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Author Information

Shengjie Sun

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Weixiong Ye

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Yangyang Xu

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Zhencheng Feng

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Qingqi Meng

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Shengjie Sun, Weixiong Ye, Yangyang Xu, Zhencheng Feng, Qingqi Meng. (2022). The Non-Ossifying Fibroma: A Case Report and Review of the Literature. Journal of Surgery, 10(4), 140-143. https://doi.org/10.11648/j.js.20221004.12

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ACS Style

Shengjie Sun; Weixiong Ye; Yangyang Xu; Zhencheng Feng; Qingqi Meng. The Non-Ossifying Fibroma: A Case Report and Review of the Literature. J. Surg. 2022, 10(4), 140-143. doi: 10.11648/j.js.20221004.12

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AMA Style

Shengjie Sun, Weixiong Ye, Yangyang Xu, Zhencheng Feng, Qingqi Meng. The Non-Ossifying Fibroma: A Case Report and Review of the Literature. J Surg. 2022;10(4):140-143. doi: 10.11648/j.js.20221004.12

Copy | Download

@article{10.11648/j.js.20221004.12,
  author = {Shengjie Sun and Weixiong Ye and Yangyang Xu and Zhencheng Feng and Qingqi Meng},
  title = {The Non-Ossifying Fibroma: A Case Report and Review of the Literature},
  journal = {Journal of Surgery},
  volume = {10},
  number = {4},
  pages = {140-143},
  doi = {10.11648/j.js.20221004.12},
  url = {https://doi.org/10.11648/j.js.20221004.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20221004.12},
  abstract = {Nonossifying fibroma is a benign tumor lesion commonly seen in children that is characterized by spontaneous regression and is usually located in the cortex of long bones, but cases occurring in other bone tissues have also been reported. It is usually not accompanied by clinical manifestations such as pain and dysfunction of the affected limb throughout the course of the disease, and the shape of the same affected limb is not significantly changed, usually found by imaging examination after injury. In this paper, we report a 12-year-old male patient who was admitted to our hospital with left lower leg pain caused by a fall during running. Emergency radiography of the left leg showed cystic swelling lesion in the cortex at the anterior edge of the left tibial metaphysis, aneurysmal bone cyst? non-ossifying fibroma? Relevant preoperative examinations were perfected after admission, and through adequate preoperative planning and discussion, it was decided to perform debridement and bone grafting of the left lower tibial tumor lesion. After operation, the function of left lower limb recovered well after professional rehabilitation training, and the therapeutic effect was satisfactory. When imaging studies after injury suspect uncured fibroma or pathological fractures, debridement and bone grafting of the lesion is necessary to prevent further aggravation of the fracture.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Non-Ossifying Fibroma: A Case Report and Review of the Literature
AU  - Shengjie Sun
AU  - Weixiong Ye
AU  - Yangyang Xu
AU  - Zhencheng Feng
AU  - Qingqi Meng
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.js.20221004.12
DO  - 10.11648/j.js.20221004.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 140
EP  - 143
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20221004.12
AB  - Nonossifying fibroma is a benign tumor lesion commonly seen in children that is characterized by spontaneous regression and is usually located in the cortex of long bones, but cases occurring in other bone tissues have also been reported. It is usually not accompanied by clinical manifestations such as pain and dysfunction of the affected limb throughout the course of the disease, and the shape of the same affected limb is not significantly changed, usually found by imaging examination after injury. In this paper, we report a 12-year-old male patient who was admitted to our hospital with left lower leg pain caused by a fall during running. Emergency radiography of the left leg showed cystic swelling lesion in the cortex at the anterior edge of the left tibial metaphysis, aneurysmal bone cyst? non-ossifying fibroma? Relevant preoperative examinations were perfected after admission, and through adequate preoperative planning and discussion, it was decided to perform debridement and bone grafting of the left lower tibial tumor lesion. After operation, the function of left lower limb recovered well after professional rehabilitation training, and the therapeutic effect was satisfactory. When imaging studies after injury suspect uncured fibroma or pathological fractures, debridement and bone grafting of the lesion is necessary to prevent further aggravation of the fracture.
VL  - 10
IS  - 4
ER  -

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