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Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

Received: 24 October 2016     Accepted: 23 November 2016     Published: 27 December 2016
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Abstract

Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.

Published in Nuclear Science (Volume 1, Issue 1)
DOI 10.11648/j.ns.20160101.12
Page(s) 6-17
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Irradiation, Radiation Syndrome, Prodromal Phase, AGE, Rats

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Cite This Article
  • APA Style

    Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. (2016). Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nuclear Science, 1(1), 6-17. https://doi.org/10.11648/j.ns.20160101.12

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    ACS Style

    Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Samba Ngano Odette; Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl. Sci. 2016, 1(1), 6-17. doi: 10.11648/j.ns.20160101.12

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    AMA Style

    Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Samba Ngano Odette, Mouelle Sone, et al. Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome. Nucl Sci. 2016;1(1):6-17. doi: 10.11648/j.ns.20160101.12

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  • @article{10.11648/j.ns.20160101.12,
      author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Samba Ngano Odette and Mouelle Sone and Ongolo Zogo Pierre and Dong à Zok Faustin and Yomi Jean and Juimo Alain George and Nko’o Amvene Samuel and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
      title = {Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome},
      journal = {Nuclear Science},
      volume = {1},
      number = {1},
      pages = {6-17},
      doi = {10.11648/j.ns.20160101.12},
      url = {https://doi.org/10.11648/j.ns.20160101.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ns.20160101.12},
      abstract = {Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome
    AU  - Kouam Foubi Brice Bertrand
    AU  - Chuisseu Djamen Dieudonné Pascal
    AU  - Dzeufiet Djomeni Paul Désiré
    AU  - Samba Ngano Odette
    AU  - Mouelle Sone
    AU  - Ongolo Zogo Pierre
    AU  - Dong à Zok Faustin
    AU  - Yomi Jean
    AU  - Juimo Alain George
    AU  - Nko’o Amvene Samuel
    AU  - Tiedeu Alain Bertin
    AU  - Gonsu Fotsin Joseph
    Y1  - 2016/12/27
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ns.20160101.12
    DO  - 10.11648/j.ns.20160101.12
    T2  - Nuclear Science
    JF  - Nuclear Science
    JO  - Nuclear Science
    SP  - 6
    EP  - 17
    PB  - Science Publishing Group
    SN  - 2640-4346
    UR  - https://doi.org/10.11648/j.ns.20160101.12
    AB  - Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon

  • Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Sciences, University of Dschang, Dschang, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

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