Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review

Kinde Bussa Senbeto; Alemwossen Teklehaymanot Alem; Bizunesh Dires Fenta; Selamawit Abebe Ayele; Abraham Kassahun Tadele; Tesfalem Israel Korga; Abebaw Amare Wodajo

doi:doi:10.11648/j.plm.20230701.13

Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review

Kinde Bussa Senbeto, Alemwossen Teklehaymanot Alem, Bizunesh Dires Fenta, Selamawit Abebe Ayele, Abraham Kassahun Tadele, Tesfalem Israel Korga, Abebaw Amare Wodajo

Published in Pathology and Laboratory Medicine (Volume 7, Issue 1)

Received: 26 April 2023 Accepted: 21 June 2023 Published: 13 July 2023

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Abstract

Most breast diseases are presented as mass lesions that can be easily detected by the patients or during clinical examination and breast imaging. Fine needle aspiration biopsy of the breast is an unquestionably useful test in differentiating various benign and malignant breast lesions however its diagnostic accuracy is still poorly known. Therefore, this study was conducted to evaluate the validity and diagnostic performance of fine needle aspiration cytology (FNAC) in diagnoses of breast masses and describe morphologic patterns of breast pathology in Hawassa University Comprehensive Specialized Hospital. This is a five years retrospective cross-sectional study of all breast lumps that underwent fine needle aspiration cytology and subsequent histopathology evaluation in the Department of Pathology, Hawassa university comprehensive specialized hospital Sidama, Ethiopia from September 2015 to August 2019. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated and morphologic patterns of breast pathology were described. Fibroadenoma and invasive ductal carcinoma were the most common benign and malignant breast lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of fine needle aspiration cytology of breast lumps were found to be 97.64%, 95.89%, 96.5%, 97.2%, and 96.8% respectively. FNAC is a valid method with high sensitivity and specificity for preoperative diagnosis of breast lesions, and we recommend the popularization of FNAC in our practice to complement histological diagnosis of breast lesions for early diagnosis and optimum treatment of our patients.

Published in	Pathology and Laboratory Medicine (Volume 7, Issue 1)
DOI	10.11648/j.plm.20230701.13
Page(s)	12-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sensitivity, Specificity, Predictive Value, Diagnostic Accuracy

References

[1]	Sudarat Nguansangiam, Somneuk Jesdapatarakul, Siriwan Tangjitgamol. Accuracy of Fine Needle Aspiration Cytology from Breast Masses in Thailand. Asian Pacific Journal of Cancer Prevention, Vol 10, 2009.
[2]	L. A. BROWN AND S. B. COGHILL. Fine needle aspiration cytology of the breast: factors affecting sensitivity. Department of Histopathology, Northampton General Hospital, Northampton. Cytopathology 199 1, 2, 67-74.
[3]	Tiwari M, Lecturer, Department of Pathology, Nepal Medical College, Nepal. Role of fine needle aspiration cytology in the diagnosis of breast lumps. Kathmandu University Medical Journal (2007), Vol. 5, No. 2, Issue 18, 215-217.
[4]	Ying-Hua Yu, Wei Wei and Jian-Lun Liu: Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis. BMC Cancer 2012, 12: 41.
[5]	Hikmatullah Qureshi, Amir Amanullah, Khalid Mahmood Khan, Farah Deeba, Department of Surgery, Khyber Teaching Hospital, Peshawar, Pakistan: JPMI 301,200 volume 21 No. 04: 301-304.
[6]	http://www.cibtech.org/cjbp.htm 2012 Vol. 1 (2) September- December, pp. 14-21/Bharambe et al.
[7]	Mulazim Hussain Bukhari, 1 Madiha Arshad, 1 Shahid Jamal, 2 Shahida Niazi, 1 Shahid Bashir, 3 Irfan M. Bakhshi, 1 and Shaharyar1, Use of Fine-Needle Aspiration in the Evaluation of Breast Lumps, Pathology Research International Volume 2011 (2011), Article ID 689521.
[8]	Bojia F, Demisse M, Dejane A, Bizuneh T. Comparison of fine-needle aspiration cytology and excisional biopsy of breast lesions. East Africa Med J. 2001 May; 78 (5): 226-8.
[9]	Rin Yamaguchi, Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan November 2012, Volume 28 Issue 5, Print ISSN: 1021-335X.
[10]	Donegan WL: Evaluation of a palpable breast mass; N Engl J med 327: 937-941; 1992.
[11]	Giard RWM, Hermans J: The value of aspiration cytologic examination of the breast, a statistical review of the medical literature; cancer 69: 2014- 22110; 1992.
[12]	Maygarden SJ, Novotny DB, Johnson DE; et al: Sub Classification of Benign Breast Disease by FNAC: comparison of cytologic and histopathologic finding in 265 palpable breast masses, Acta cytol 38; 115-129; 1994a.
[13]	Josip Mišković, Andrea Zorić, Helena Radić Mišković, and Violeta Šoljić: Diagnostic Value Of Fine Needle Aspiration Cytology For Breast Tumors, Acta Clin Croat, Vol. 55, No. 4: 625-628; 2016.
[14]	Kumar Harsh, Buch Archana C, Pal Sukanya, Chandanwale Shirish S And Joshi Rohan V: Role Of Fine Needle Aspiration Cytology As “One Stop” Diagnosis For Assessment Of Breast Lumps In Women; ISSN 2250-0480 VOL 6/ ISSUE 2/ L8- L13; APRIL 2016.
[15]	Yohannis Abraham (MD): sensitivity and specificity of FNAC on breast mass as compared to histology evaluation; Google, 9-10; Oct. 2014.
[16]	Adetola Olubunmi Daramole et al: Correlation between FNAC and histology for palpable breast masses in Nigeria tertiary health institution; International journal of breast carcinoma, volume 2015, Article ID 742573, 5 pages.
[17]	David E Ibikule et al: FNAC of breast lumps with histologic correlation in Owo, Ondo state Nigeria, A five review; Ghana Med J. 2017 Mar; 51 (1): 1-5.
[18]	Andrew S. Field et al: The International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytopathology; Acta Cytologica 2019; 63: 257-273.

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APA Style

Kinde Bussa Senbeto, Alemwossen Teklehaymanot Alem, Bizunesh Dires Fenta, Selamawit Abebe Ayele, Abraham Kassahun Tadele, et al. (2023). Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathology and Laboratory Medicine, 7(1), 12-17. https://doi.org/10.11648/j.plm.20230701.13

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ACS Style

Kinde Bussa Senbeto; Alemwossen Teklehaymanot Alem; Bizunesh Dires Fenta; Selamawit Abebe Ayele; Abraham Kassahun Tadele, et al. Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathol. Lab. Med. 2023, 7(1), 12-17. doi: 10.11648/j.plm.20230701.13

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AMA Style

Kinde Bussa Senbeto, Alemwossen Teklehaymanot Alem, Bizunesh Dires Fenta, Selamawit Abebe Ayele, Abraham Kassahun Tadele, et al. Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathol Lab Med. 2023;7(1):12-17. doi: 10.11648/j.plm.20230701.13

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@article{10.11648/j.plm.20230701.13,
  author = {Kinde Bussa Senbeto and Alemwossen Teklehaymanot Alem and Bizunesh Dires Fenta and Selamawit Abebe Ayele and Abraham Kassahun Tadele and Tesfalem Israel Korga and Abebaw Amare Wodajo},
  title = {Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review},
  journal = {Pathology and Laboratory Medicine},
  volume = {7},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.plm.20230701.13},
  url = {https://doi.org/10.11648/j.plm.20230701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20230701.13},
  abstract = {Most breast diseases are presented as mass lesions that can be easily detected by the patients or during clinical examination and breast imaging. Fine needle aspiration biopsy of the breast is an unquestionably useful test in differentiating various benign and malignant breast lesions however its diagnostic accuracy is still poorly known. Therefore, this study was conducted to evaluate the validity and diagnostic performance of fine needle aspiration cytology (FNAC) in diagnoses of breast masses and describe morphologic patterns of breast pathology in Hawassa University Comprehensive Specialized Hospital. This is a five years retrospective cross-sectional study of all breast lumps that underwent fine needle aspiration cytology and subsequent histopathology evaluation in the Department of Pathology, Hawassa university comprehensive specialized hospital Sidama, Ethiopia from September 2015 to August 2019. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated and morphologic patterns of breast pathology were described. Fibroadenoma and invasive ductal carcinoma were the most common benign and malignant breast lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of fine needle aspiration cytology of breast lumps were found to be 97.64%, 95.89%, 96.5%, 97.2%, and 96.8% respectively. FNAC is a valid method with high sensitivity and specificity for preoperative diagnosis of breast lesions, and we recommend the popularization of FNAC in our practice to complement histological diagnosis of breast lesions for early diagnosis and optimum treatment of our patients.},
 year = {2023}
}

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TY  - JOUR
T1  - Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review
AU  - Kinde Bussa Senbeto
AU  - Alemwossen Teklehaymanot Alem
AU  - Bizunesh Dires Fenta
AU  - Selamawit Abebe Ayele
AU  - Abraham Kassahun Tadele
AU  - Tesfalem Israel Korga
AU  - Abebaw Amare Wodajo
Y1  - 2023/07/13
PY  - 2023
N1  - https://doi.org/10.11648/j.plm.20230701.13
DO  - 10.11648/j.plm.20230701.13
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20230701.13
AB  - Most breast diseases are presented as mass lesions that can be easily detected by the patients or during clinical examination and breast imaging. Fine needle aspiration biopsy of the breast is an unquestionably useful test in differentiating various benign and malignant breast lesions however its diagnostic accuracy is still poorly known. Therefore, this study was conducted to evaluate the validity and diagnostic performance of fine needle aspiration cytology (FNAC) in diagnoses of breast masses and describe morphologic patterns of breast pathology in Hawassa University Comprehensive Specialized Hospital. This is a five years retrospective cross-sectional study of all breast lumps that underwent fine needle aspiration cytology and subsequent histopathology evaluation in the Department of Pathology, Hawassa university comprehensive specialized hospital Sidama, Ethiopia from September 2015 to August 2019. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated and morphologic patterns of breast pathology were described. Fibroadenoma and invasive ductal carcinoma were the most common benign and malignant breast lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of fine needle aspiration cytology of breast lumps were found to be 97.64%, 95.89%, 96.5%, 97.2%, and 96.8% respectively. FNAC is a valid method with high sensitivity and specificity for preoperative diagnosis of breast lesions, and we recommend the popularization of FNAC in our practice to complement histological diagnosis of breast lesions for early diagnosis and optimum treatment of our patients.
VL  - 7
IS  - 1
ER  -

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Author Information

Kinde Bussa Senbeto

Department of Pathology, Arbaminch University College of Medicine and Health Sciences, Arbaminch, Ethiopia
Alemwossen Teklehaymanot Alem

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia
Bizunesh Dires Fenta

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia
Selamawit Abebe Ayele

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia
Abraham Kassahun Tadele

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia
Tesfalem Israel Korga

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia
Abebaw Amare Wodajo

Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

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APA Style

Kinde Bussa Senbeto, Alemwossen Teklehaymanot Alem, Bizunesh Dires Fenta, Selamawit Abebe Ayele, Abraham Kassahun Tadele, et al. (2023). Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathology and Laboratory Medicine, 7(1), 12-17. https://doi.org/10.11648/j.plm.20230701.13

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ACS Style

Kinde Bussa Senbeto; Alemwossen Teklehaymanot Alem; Bizunesh Dires Fenta; Selamawit Abebe Ayele; Abraham Kassahun Tadele, et al. Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathol. Lab. Med. 2023, 7(1), 12-17. doi: 10.11648/j.plm.20230701.13

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AMA Style

Kinde Bussa Senbeto, Alemwossen Teklehaymanot Alem, Bizunesh Dires Fenta, Selamawit Abebe Ayele, Abraham Kassahun Tadele, et al. Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review. Pathol Lab Med. 2023;7(1):12-17. doi: 10.11648/j.plm.20230701.13

Copy | Download

@article{10.11648/j.plm.20230701.13,
  author = {Kinde Bussa Senbeto and Alemwossen Teklehaymanot Alem and Bizunesh Dires Fenta and Selamawit Abebe Ayele and Abraham Kassahun Tadele and Tesfalem Israel Korga and Abebaw Amare Wodajo},
  title = {Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review},
  journal = {Pathology and Laboratory Medicine},
  volume = {7},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.plm.20230701.13},
  url = {https://doi.org/10.11648/j.plm.20230701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20230701.13},
  abstract = {Most breast diseases are presented as mass lesions that can be easily detected by the patients or during clinical examination and breast imaging. Fine needle aspiration biopsy of the breast is an unquestionably useful test in differentiating various benign and malignant breast lesions however its diagnostic accuracy is still poorly known. Therefore, this study was conducted to evaluate the validity and diagnostic performance of fine needle aspiration cytology (FNAC) in diagnoses of breast masses and describe morphologic patterns of breast pathology in Hawassa University Comprehensive Specialized Hospital. This is a five years retrospective cross-sectional study of all breast lumps that underwent fine needle aspiration cytology and subsequent histopathology evaluation in the Department of Pathology, Hawassa university comprehensive specialized hospital Sidama, Ethiopia from September 2015 to August 2019. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated and morphologic patterns of breast pathology were described. Fibroadenoma and invasive ductal carcinoma were the most common benign and malignant breast lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of fine needle aspiration cytology of breast lumps were found to be 97.64%, 95.89%, 96.5%, 97.2%, and 96.8% respectively. FNAC is a valid method with high sensitivity and specificity for preoperative diagnosis of breast lesions, and we recommend the popularization of FNAC in our practice to complement histological diagnosis of breast lesions for early diagnosis and optimum treatment of our patients.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Diagnostic Accuracy of Fine Needle Aspiration Cytology of Breast Masses, and Morphologic Patterns of Breast Lesions, Hawassa, Sidama Ethiopia: A Five-Year Review
AU  - Kinde Bussa Senbeto
AU  - Alemwossen Teklehaymanot Alem
AU  - Bizunesh Dires Fenta
AU  - Selamawit Abebe Ayele
AU  - Abraham Kassahun Tadele
AU  - Tesfalem Israel Korga
AU  - Abebaw Amare Wodajo
Y1  - 2023/07/13
PY  - 2023
N1  - https://doi.org/10.11648/j.plm.20230701.13
DO  - 10.11648/j.plm.20230701.13
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20230701.13
AB  - Most breast diseases are presented as mass lesions that can be easily detected by the patients or during clinical examination and breast imaging. Fine needle aspiration biopsy of the breast is an unquestionably useful test in differentiating various benign and malignant breast lesions however its diagnostic accuracy is still poorly known. Therefore, this study was conducted to evaluate the validity and diagnostic performance of fine needle aspiration cytology (FNAC) in diagnoses of breast masses and describe morphologic patterns of breast pathology in Hawassa University Comprehensive Specialized Hospital. This is a five years retrospective cross-sectional study of all breast lumps that underwent fine needle aspiration cytology and subsequent histopathology evaluation in the Department of Pathology, Hawassa university comprehensive specialized hospital Sidama, Ethiopia from September 2015 to August 2019. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated and morphologic patterns of breast pathology were described. Fibroadenoma and invasive ductal carcinoma were the most common benign and malignant breast lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of fine needle aspiration cytology of breast lumps were found to be 97.64%, 95.89%, 96.5%, 97.2%, and 96.8% respectively. FNAC is a valid method with high sensitivity and specificity for preoperative diagnosis of breast lesions, and we recommend the popularization of FNAC in our practice to complement histological diagnosis of breast lesions for early diagnosis and optimum treatment of our patients.
VL  - 7
IS  - 1
ER  -

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