Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

Zuhair A-A. Khammas; Rana Abbas Rashid

doi:doi:10.11648/j.sjac.20150305.14

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Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

Zuhair A-A. Khammas, Rana Abbas Rashid

Published in Science Journal of Analytical Chemistry (Volume 3, Issue 5)

Received: 27 August 2015 Accepted: 7 September 2015 Published: 16 September 2015

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Abstract

A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL^-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL^-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL^-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.

Published in	Science Journal of Analytical Chemistry (Volume 3, Issue 5)
DOI	10.11648/j.sjac.20150305.14
Page(s)	61-70
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Trifluoperazine Hydrochloride, Vanadium (V) Ions, Hydrophobic Complex, Cloud Point Extraction, Vis - Spectrophotometry

References

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Zuhair A-A. Khammas, Rana Abbas Rashid. (2015). Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Science Journal of Analytical Chemistry, 3(5), 61-70. https://doi.org/10.11648/j.sjac.20150305.14

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ACS Style

Zuhair A-A. Khammas; Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci. J. Anal. Chem. 2015, 3(5), 61-70. doi: 10.11648/j.sjac.20150305.14

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AMA Style

Zuhair A-A. Khammas, Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci J Anal Chem. 2015;3(5):61-70. doi: 10.11648/j.sjac.20150305.14

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@article{10.11648/j.sjac.20150305.14,
  author = {Zuhair A-A. Khammas and Rana Abbas Rashid},
  title = {Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction},
  journal = {Science Journal of Analytical Chemistry},
  volume = {3},
  number = {5},
  pages = {61-70},
  doi = {10.11648/j.sjac.20150305.14},
  url = {https://doi.org/10.11648/j.sjac.20150305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20150305.14},
  abstract = {A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.},
 year = {2015}
}

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TY  - JOUR
T1  - Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction
AU  - Zuhair A-A. Khammas
AU  - Rana Abbas Rashid
Y1  - 2015/09/16
PY  - 2015
N1  - https://doi.org/10.11648/j.sjac.20150305.14
DO  - 10.11648/j.sjac.20150305.14
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 61
EP  - 70
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20150305.14
AB  - A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.
VL  - 3
IS  - 5
ER  -

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Author Information

Zuhair A-A. Khammas

Department of Chemistry, College of Science for Women, University of Baghdad, Jadiyriah, Baghdad, Iraq
Rana Abbas Rashid

Department of Chemistry, College of Science for Women, University of Baghdad, Jadiyriah, Baghdad, Iraq

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Zuhair A-A. Khammas, Rana Abbas Rashid. (2015). Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Science Journal of Analytical Chemistry, 3(5), 61-70. https://doi.org/10.11648/j.sjac.20150305.14

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ACS Style

Zuhair A-A. Khammas; Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci. J. Anal. Chem. 2015, 3(5), 61-70. doi: 10.11648/j.sjac.20150305.14

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AMA Style

Zuhair A-A. Khammas, Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci J Anal Chem. 2015;3(5):61-70. doi: 10.11648/j.sjac.20150305.14

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@article{10.11648/j.sjac.20150305.14,
  author = {Zuhair A-A. Khammas and Rana Abbas Rashid},
  title = {Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction},
  journal = {Science Journal of Analytical Chemistry},
  volume = {3},
  number = {5},
  pages = {61-70},
  doi = {10.11648/j.sjac.20150305.14},
  url = {https://doi.org/10.11648/j.sjac.20150305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20150305.14},
  abstract = {A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction
AU  - Zuhair A-A. Khammas
AU  - Rana Abbas Rashid
Y1  - 2015/09/16
PY  - 2015
N1  - https://doi.org/10.11648/j.sjac.20150305.14
DO  - 10.11648/j.sjac.20150305.14
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 61
EP  - 70
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20150305.14
AB  - A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.
VL  - 3
IS  - 5
ER  -

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