Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.
| Published in | Science Journal of Analytical Chemistry (Volume 4, Issue 3) |
| DOI | 10.11648/j.sjac.20160403.12 |
| Page(s) | 26-29 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
HPLC, Antimalarial, Quinine, Hemodialysis, Chronic Renal Failure
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APA Style
Christophe N’cho Amin, Philippe André Sawa Kpaibé, Nicaise François Bony, Gildas Komenan Gbassi, Michèle Aké, et al. (2016). Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Science Journal of Analytical Chemistry, 4(3), 26-29. https://doi.org/10.11648/j.sjac.20160403.12
ACS Style
Christophe N’cho Amin; Philippe André Sawa Kpaibé; Nicaise François Bony; Gildas Komenan Gbassi; Michèle Aké, et al. Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Sci. J. Anal. Chem. 2016, 4(3), 26-29. doi: 10.11648/j.sjac.20160403.12
AMA Style
Christophe N’cho Amin, Philippe André Sawa Kpaibé, Nicaise François Bony, Gildas Komenan Gbassi, Michèle Aké, et al. Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Sci J Anal Chem. 2016;4(3):26-29. doi: 10.11648/j.sjac.20160403.12
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Download@article{10.11648/j.sjac.20160403.12,
author = {Christophe N’cho Amin and Philippe André Sawa Kpaibé and Nicaise François Bony and Gildas Komenan Gbassi and Michèle Aké and Apollinaire Gnionsahé and Eugène Atindehou},
title = {Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis},
journal = {Science Journal of Analytical Chemistry},
volume = {4},
number = {3},
pages = {26-29},
doi = {10.11648/j.sjac.20160403.12},
url = {https://doi.org/10.11648/j.sjac.20160403.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20160403.12},
abstract = {Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.},
year = {2016}
}
TY - JOUR T1 - Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis AU - Christophe N’cho Amin AU - Philippe André Sawa Kpaibé AU - Nicaise François Bony AU - Gildas Komenan Gbassi AU - Michèle Aké AU - Apollinaire Gnionsahé AU - Eugène Atindehou Y1 - 2016/05/03 PY - 2016 N1 - https://doi.org/10.11648/j.sjac.20160403.12 DO - 10.11648/j.sjac.20160403.12 T2 - Science Journal of Analytical Chemistry JF - Science Journal of Analytical Chemistry JO - Science Journal of Analytical Chemistry SP - 26 EP - 29 PB - Science Publishing Group SN - 2376-8053 UR - https://doi.org/10.11648/j.sjac.20160403.12 AB - Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment. VL - 4 IS - 3 ER -
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