A Novel Synthesis Technology of Ethyl-β-Cyclodextrin

Gan Yongjiang; Zhang Bei; Zhang Yimin; Ling Shanfeng

doi:doi:10.11648/j.sjc.20210903.12

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A Novel Synthesis Technology of Ethyl-β-Cyclodextrin

Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng

Published in Science Journal of Chemistry (Volume 9, Issue 3)

Received: 18 April 2021 Accepted: 5 May 2021 Published: 20 May 2021

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Abstract

A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, ¹H-NMR and ¹³C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.

Published in	Science Journal of Chemistry (Volume 9, Issue 3)
DOI	10.11648/j.sjc.20210903.12
Page(s)	68-71
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

β-Cyclodextrin, Orthogonal Experiments, Diethyl Carbonate, Ethylation, NMR

References

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APA Style

Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. (2021). A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Science Journal of Chemistry, 9(3), 68-71. https://doi.org/10.11648/j.sjc.20210903.12

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ACS Style

Gan Yongjiang; Zhang Bei; Zhang Yimin; Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci. J. Chem. 2021, 9(3), 68-71. doi: 10.11648/j.sjc.20210903.12

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AMA Style

Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci J Chem. 2021;9(3):68-71. doi: 10.11648/j.sjc.20210903.12

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@article{10.11648/j.sjc.20210903.12,
  author = {Gan Yongjiang and Zhang Bei and Zhang Yimin and Ling Shanfeng},
  title = {A Novel Synthesis Technology of Ethyl-β-Cyclodextrin},
  journal = {Science Journal of Chemistry},
  volume = {9},
  number = {3},
  pages = {68-71},
  doi = {10.11648/j.sjc.20210903.12},
  url = {https://doi.org/10.11648/j.sjc.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210903.12},
  abstract = {A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.},
 year = {2021}
}

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TY  - JOUR
T1  - A Novel Synthesis Technology of Ethyl-β-Cyclodextrin
AU  - Gan Yongjiang
AU  - Zhang Bei
AU  - Zhang Yimin
AU  - Ling Shanfeng
Y1  - 2021/05/20
PY  - 2021
N1  - https://doi.org/10.11648/j.sjc.20210903.12
DO  - 10.11648/j.sjc.20210903.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 68
EP  - 71
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20210903.12
AB  - A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.
VL  - 9
IS  - 3
ER  -

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Author Information

Gan Yongjiang

Shanwei Vocational and Technical College, Shanwei, China
Zhang Bei

Shanwei Vocational and Technical College, Shanwei, China
Zhang Yimin

Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
Ling Shanfeng

Shanwei Vocational and Technical College, Shanwei, China

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Plain Text BibTeX RIS

APA Style

Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. (2021). A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Science Journal of Chemistry, 9(3), 68-71. https://doi.org/10.11648/j.sjc.20210903.12

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ACS Style

Gan Yongjiang; Zhang Bei; Zhang Yimin; Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci. J. Chem. 2021, 9(3), 68-71. doi: 10.11648/j.sjc.20210903.12

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AMA Style

Gan Yongjiang, Zhang Bei, Zhang Yimin, Ling Shanfeng. A Novel Synthesis Technology of Ethyl-β-Cyclodextrin. Sci J Chem. 2021;9(3):68-71. doi: 10.11648/j.sjc.20210903.12

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@article{10.11648/j.sjc.20210903.12,
  author = {Gan Yongjiang and Zhang Bei and Zhang Yimin and Ling Shanfeng},
  title = {A Novel Synthesis Technology of Ethyl-β-Cyclodextrin},
  journal = {Science Journal of Chemistry},
  volume = {9},
  number = {3},
  pages = {68-71},
  doi = {10.11648/j.sjc.20210903.12},
  url = {https://doi.org/10.11648/j.sjc.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210903.12},
  abstract = {A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - A Novel Synthesis Technology of Ethyl-β-Cyclodextrin
AU  - Gan Yongjiang
AU  - Zhang Bei
AU  - Zhang Yimin
AU  - Ling Shanfeng
Y1  - 2021/05/20
PY  - 2021
N1  - https://doi.org/10.11648/j.sjc.20210903.12
DO  - 10.11648/j.sjc.20210903.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 68
EP  - 71
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20210903.12
AB  - A novel green synthesis process about ethyl-β-Cyclodextrin have been investigated through the reaction between β-cyclodextrin and diethyl carbonate by used anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including reaction time, the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature and contents of anhydrous potassium carbonate on the average degree of substitution of ethyl-β-cyclodextrin were carried out by a design method of orthogonal experiments. The results shown that the average degree of substitution of ethyl-β-cyclodextrin can be depend on the reaction temperature and the molar ratio of raw material primarily. The optimal maximum average degree of substitution of ethyl-β-cyclodextrin is 6.0 when the molar ratio of β-cyclodextrin to diethyl carbonate, reaction temperature, reaction time and dosage of catalyst are 1:28, 120°C, 24h and 2.0 g, respectively. The structures of ethyl-β-cyclodextrin were characterized by TLC, IR, MS, 1H-NMR and 13C-NMR, and these results are concordant with former ones which synthesized ethyl-β-cyclodextrin by diethyl sulfate or ethyl iodide.
VL  - 9
IS  - 3
ER  -

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