Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)

Niouma Nestor Leno; Pierre Pepe Sovogui; Serge Mayaka Ma-Nitu; Iya Saidou Condé; Oscar Loua; Albert Camara; Alioune Camara; Alexandre Delamou

doi:doi:10.11648/j.sjph.20251301.18

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Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)

Niouma Nestor Leno^*

, Pierre Pepe Sovogui, Serge Mayaka Ma-Nitu

, Iya Saidou Condé, Oscar Loua, Albert Camara, Alioune Camara

, Alexandre Delamou

Published in Science Journal of Public Health (Volume 13, Issue 1)

Received: 24 December 2024 Accepted: 27 January 2025 Published: 26 February 2025

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Abstract

Background: This study assesses the retention rate of patients living with HIV in the antiretroviral treatment (ART) program at Donka the National Hospital, Guinea, and identifies predictors of non-retention. Methods: Conducted as a retrospective cohort study from May 2018 to March 2023, it involved 4,169 HIV-positive patients aged 10 and older, who had been on antiretroviral treatment program for at least six months. Retention rates were estimated using Kaplan-Meier techniques, and multivariate Cox regression identified factors associated with non-retention. Results: Results showed a cumulative retention rate of 68.88%, declining over time: 91.3% at six months, 74.1% at 24 months, and 53.1% at 60 months. The study identified significant predictors of non-retention, including low CD4 counts (<100 cells/mm³: adjusted HR 2.158; 100-200 cells/mm³: adjusted HR 1.729), advanced HIV stages (III/IV) at treatment initiation (adjusted HR 1.335), and the use of "AZT + 3TC + NVP" regimen (adjusted HR 1.443). Most participants were women (66.2%) with a median age of 37 years, and a majority were unemployed (57.8%). Conclusion: The findings highlight a retention rate below the national target of 90%, with late treatment initiation and low CD4 counts as major barriers. The study calls for further qualitative and quantitative research to understand patient loss to follow-up and improve ART program retention and HIV care in Guinea.

Published in	Science Journal of Public Health (Volume 13, Issue 1)
DOI	10.11648/j.sjph.20251301.18
Page(s)	70-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Antiretroviral Treatment, HIV/AIDS, Retention, Factors Associated, Conakry

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APA Style

Leno, N. N., Sovogui, P. P., Ma-Nitu, S. M., Condé, I. S., Loua, O., et al. (2025). Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Science Journal of Public Health, 13(1), 70-81. https://doi.org/10.11648/j.sjph.20251301.18

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ACS Style

Leno, N. N.; Sovogui, P. P.; Ma-Nitu, S. M.; Condé, I. S.; Loua, O., et al. Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Sci. J. Public Health 2025, 13(1), 70-81. doi: 10.11648/j.sjph.20251301.18

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AMA Style

Leno NN, Sovogui PP, Ma-Nitu SM, Condé IS, Loua O, et al. Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Sci J Public Health. 2025;13(1):70-81. doi: 10.11648/j.sjph.20251301.18

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@article{10.11648/j.sjph.20251301.18,
  author = {Niouma Nestor Leno and Pierre Pepe Sovogui and Serge Mayaka Ma-Nitu and Iya Saidou Condé and Oscar Loua and Albert Camara and Alioune Camara and Alexandre Delamou},
  title = {Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)
},
  journal = {Science Journal of Public Health},
  volume = {13},
  number = {1},
  pages = {70-81},
  doi = {10.11648/j.sjph.20251301.18},
  url = {https://doi.org/10.11648/j.sjph.20251301.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20251301.18},
  abstract = {Background: This study assesses the retention rate of patients living with HIV in the antiretroviral treatment (ART) program at Donka the National Hospital, Guinea, and identifies predictors of non-retention. Methods: Conducted as a retrospective cohort study from May 2018 to March 2023, it involved 4,169 HIV-positive patients aged 10 and older, who had been on antiretroviral treatment program for at least six months. Retention rates were estimated using Kaplan-Meier techniques, and multivariate Cox regression identified factors associated with non-retention. Results: Results showed a cumulative retention rate of 68.88%, declining over time: 91.3% at six months, 74.1% at 24 months, and 53.1% at 60 months. The study identified significant predictors of non-retention, including low CD4 counts (Conclusion: The findings highlight a retention rate below the national target of 90%, with late treatment initiation and low CD4 counts as major barriers. The study calls for further qualitative and quantitative research to understand patient loss to follow-up and improve ART program retention and HIV care in Guinea.
},
 year = {2025}
}

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TY  - JOUR
T1  - Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)

AU  - Niouma Nestor Leno
AU  - Pierre Pepe Sovogui
AU  - Serge Mayaka Ma-Nitu
AU  - Iya Saidou Condé
AU  - Oscar Loua
AU  - Albert Camara
AU  - Alioune Camara
AU  - Alexandre Delamou
Y1  - 2025/02/26
PY  - 2025
N1  - https://doi.org/10.11648/j.sjph.20251301.18
DO  - 10.11648/j.sjph.20251301.18
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 70
EP  - 81
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20251301.18
AB  - Background: This study assesses the retention rate of patients living with HIV in the antiretroviral treatment (ART) program at Donka the National Hospital, Guinea, and identifies predictors of non-retention. Methods: Conducted as a retrospective cohort study from May 2018 to March 2023, it involved 4,169 HIV-positive patients aged 10 and older, who had been on antiretroviral treatment program for at least six months. Retention rates were estimated using Kaplan-Meier techniques, and multivariate Cox regression identified factors associated with non-retention. Results: Results showed a cumulative retention rate of 68.88%, declining over time: 91.3% at six months, 74.1% at 24 months, and 53.1% at 60 months. The study identified significant predictors of non-retention, including low CD4 counts (Conclusion: The findings highlight a retention rate below the national target of 90%, with late treatment initiation and low CD4 counts as major barriers. The study calls for further qualitative and quantitative research to understand patient loss to follow-up and improve ART program retention and HIV care in Guinea.

VL  - 13
IS  - 1
ER  -

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Author Information

Niouma Nestor Leno

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea; African Center of Excellence for Infection Prevention and Control, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

Contact Email

http://orcid.org/0000-0002-2863-2267
Pierre Pepe Sovogui

African Center of Excellence for Infection Prevention and Control, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

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Serge Mayaka Ma-Nitu

National School of Public Health of Kinshasa, Kinshasa, Democratic Republic of Congo

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http://orcid.org/0000-0002-9124-2114
Iya Saidou Condé

Ministry of Health and Public Hygiene, Conakry, Guinea

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Oscar Loua

Ministry of Health and Public Hygiene, Conakry, Guinea

Contact Email
Albert Camara

Ministry of Health and Public Hygiene, Conakry, Guinea

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Alioune Camara

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea; African Center of Excellence for Infection Prevention and Control, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

Contact Email

http://orcid.org/0000-0001-5874-4641
Alexandre Delamou

Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea; African Center of Excellence for Infection Prevention and Control, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

Contact Email

http://orcid.org/0000-0002-9397-7106

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Plain Text BibTeX RIS

APA Style

Leno, N. N., Sovogui, P. P., Ma-Nitu, S. M., Condé, I. S., Loua, O., et al. (2025). Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Science Journal of Public Health, 13(1), 70-81. https://doi.org/10.11648/j.sjph.20251301.18

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ACS Style

Leno, N. N.; Sovogui, P. P.; Ma-Nitu, S. M.; Condé, I. S.; Loua, O., et al. Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Sci. J. Public Health 2025, 13(1), 70-81. doi: 10.11648/j.sjph.20251301.18

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AMA Style

Leno NN, Sovogui PP, Ma-Nitu SM, Condé IS, Loua O, et al. Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023). Sci J Public Health. 2025;13(1):70-81. doi: 10.11648/j.sjph.20251301.18

Copy | Download

@article{10.11648/j.sjph.20251301.18,
  author = {Niouma Nestor Leno and Pierre Pepe Sovogui and Serge Mayaka Ma-Nitu and Iya Saidou Condé and Oscar Loua and Albert Camara and Alioune Camara and Alexandre Delamou},
  title = {Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)
},
  journal = {Science Journal of Public Health},
  volume = {13},
  number = {1},
  pages = {70-81},
  doi = {10.11648/j.sjph.20251301.18},
  url = {https://doi.org/10.11648/j.sjph.20251301.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20251301.18},
  abstract = {Background: This study assesses the retention rate of patients living with HIV in the antiretroviral treatment (ART) program at Donka the National Hospital, Guinea, and identifies predictors of non-retention. Methods: Conducted as a retrospective cohort study from May 2018 to March 2023, it involved 4,169 HIV-positive patients aged 10 and older, who had been on antiretroviral treatment program for at least six months. Retention rates were estimated using Kaplan-Meier techniques, and multivariate Cox regression identified factors associated with non-retention. Results: Results showed a cumulative retention rate of 68.88%, declining over time: 91.3% at six months, 74.1% at 24 months, and 53.1% at 60 months. The study identified significant predictors of non-retention, including low CD4 counts (Conclusion: The findings highlight a retention rate below the national target of 90%, with late treatment initiation and low CD4 counts as major barriers. The study calls for further qualitative and quantitative research to understand patient loss to follow-up and improve ART program retention and HIV care in Guinea.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Associated Factors with Non-retention of People Living with HIV in the Antiretroviral Treatment Program at the Donka National Hospital, Conakry: A Five-year Retrospective Cohort Study (2018 - 2023)

AU  - Niouma Nestor Leno
AU  - Pierre Pepe Sovogui
AU  - Serge Mayaka Ma-Nitu
AU  - Iya Saidou Condé
AU  - Oscar Loua
AU  - Albert Camara
AU  - Alioune Camara
AU  - Alexandre Delamou
Y1  - 2025/02/26
PY  - 2025
N1  - https://doi.org/10.11648/j.sjph.20251301.18
DO  - 10.11648/j.sjph.20251301.18
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 70
EP  - 81
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20251301.18
AB  - Background: This study assesses the retention rate of patients living with HIV in the antiretroviral treatment (ART) program at Donka the National Hospital, Guinea, and identifies predictors of non-retention. Methods: Conducted as a retrospective cohort study from May 2018 to March 2023, it involved 4,169 HIV-positive patients aged 10 and older, who had been on antiretroviral treatment program for at least six months. Retention rates were estimated using Kaplan-Meier techniques, and multivariate Cox regression identified factors associated with non-retention. Results: Results showed a cumulative retention rate of 68.88%, declining over time: 91.3% at six months, 74.1% at 24 months, and 53.1% at 60 months. The study identified significant predictors of non-retention, including low CD4 counts (Conclusion: The findings highlight a retention rate below the national target of 90%, with late treatment initiation and low CD4 counts as major barriers. The study calls for further qualitative and quantitative research to understand patient loss to follow-up and improve ART program retention and HIV care in Guinea.

VL  - 13
IS  - 1
ER  -

Copy | Download