Possible Treatment of <i>Mycobacterium Lepramatous</i> with Bovine Milk

Jesus’ Christus; Michael Arden Madson

doi:doi:10.11648/j.wjfst.20180203.11

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Possible Treatment of Mycobacterium Lepramatous with Bovine Milk

Jesus’ Christus, Michael Arden Madson

Published in World Journal of Food Science and Technology (Volume 2, Issue 3)

Received: 26 August 2018 Accepted: 12 September 2018 Published: 17 December 2018

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Abstract

Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.

Published in	World Journal of Food Science and Technology (Volume 2, Issue 3)
DOI	10.11648/j.wjfst.20180203.11
Page(s)	55-61
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Mass Spectrometry, HPAEC-PAD, Molecular Characterization, Bovine Milk, Possible M. Lepramatous Treatment

References

[1]	Bochud, P-Y.; Hawn, T,; Siddipu, M.; Saunderson, P.; Britton, S,; Abraham, I.; Argaw, A.; Jana, M.; Zhao, L.; Kaplan, G. et al. Toll Like Receptor (TLR2) Polymorhisms are Associated with Reversal Reaction in Leprosy J. Infectious Diseases (2007) 197 264 CAPLUS.
[2]	Amith, S.; Jayanth P.; Franchuk,S.; Finlay, T.; Seyrantepe, V.; Rbeyaert, R.; Pshezhetsky, A.; Szewczuk, M.; Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling Cellular Signaling 314-324 (2010).
[3]	Madson, M.; Method of testing for a milk trisaccharide US 8,993, 226 B2 patent March 31st (2015).
[4]	Madson, M.; Mass Spectrometry Techniques for Structural Characterization of Glycans, Elsevier, New York 2016.
[5]	Parkkinen, J.; Finne, J.; Isolation of sialyl oligosaccharides and sialyl oligosaccharide phosphates from bovine colostrum and human urine Methods in Enzymology 138 289-300 (1987).
[6]	Madson, M.; Method of discerning substitution of carbohydrate esters patent US 9,726,671 B2 August 8th 2017.
[7]	Madson, M.; Manufacturing of MeOH, formaldehyde, formic acid and ammonium pentaborate tetrahydrate from CO2 US 8,685,355 B2 patent April 1st 2015.
[8]	Pfeffer, P.; Valentine, K.; Parrish, F.; Deuterium-induced differential isotope shift carbon-13 NMR 1 Resonance reassignments of mono- and disaccharides J. Am. Chem. Soc. 101 (5) 1265-1274 (1979).
[9]	Madson, M.; Zhang, Z.; Linhardt, R.; The presence of lactose sulfate in bovine milk Carbohydrate Gordon Research Conference, poster Tilton, NH June (2007).
[10]	Orllandi, P.; Klotz, F.; Haynes, J.; A Malaria Invasion Receptor, the 175 kilodalton Erythrocyte Binding Antigen of Plasmodium falciparum Recognizes the Terminal Neu5Ac (α2-3) Gal- Sequences of glycophorin A. J. Cell Biology 116 (4) 901-909 (1992).
[11]	Kijima-Suda, I.; Miyamoto, Y.; Itoh, M.; Toyoshima, S.; Osawa, T.; Possible Mechanism of Inhibition of Experimental Pulmonary Metastasis of Mouse Colon Adenocarcinoma 26 Sublines by a Sialic: Nucleoside Conjugate. Cancer Res. 8 (13) 3728-32 (1988).
[12]	Otek, I.; Hasty, D.; Sharon, N.; Antiadhesion therapy of bacterial diseases: prospects and problems. FEMS Immunology and Medical Microbiology 38 181-191 (2003).
[13]	Bode, L.; Muly-Reinholz, M.; Mayer, K.; Seeger, W.; Rudolf, S.; Inhibition of monocyte, lymphocyte and neutrophil adhesion to endothelial cells by human milk oligosaccharides. Thromb. Haemost. 92 (6) 1402-1410 (2004).
[14]	Maury, L.; Teppoand, A.; Wegelius, O.; Relationship between urinary sialylated saccharides, serum amyloid A protein, C reactive protein in rheumatoid arthritis and systematic lupus erythematous. Ann. Rheum. Dis. 268-271 (1982).
[15]	M’rabat, L.; van Baalen, A.; Stahl, B.; Vos, A.; Snoeren, T.; Milk oligosaccharide for stimulating the immune system Application number: 12/29468, Publication date: 2/11/2010. Assignee: N.V. Nutricia.
[16]	Madson, M.; Method isolating and identifying fruit oligosaccharides from ripe banana fruit US 9,557,335 B2 patent Jan. 31^st (2017).

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Jesus’ Christus, Michael Arden Madson. (2018). Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World Journal of Food Science and Technology, 2(3), 55-61. https://doi.org/10.11648/j.wjfst.20180203.11

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ACS Style

Jesus’ Christus; Michael Arden Madson. Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World J. Food Sci. Technol. 2018, 2(3), 55-61. doi: 10.11648/j.wjfst.20180203.11

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AMA Style

Jesus’ Christus, Michael Arden Madson. Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World J Food Sci Technol. 2018;2(3):55-61. doi: 10.11648/j.wjfst.20180203.11

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@article{10.11648/j.wjfst.20180203.11,
  author = {Jesus’ Christus and Michael Arden Madson},
  title = {Possible Treatment of Mycobacterium Lepramatous with Bovine Milk},
  journal = {World Journal of Food Science and Technology},
  volume = {2},
  number = {3},
  pages = {55-61},
  doi = {10.11648/j.wjfst.20180203.11},
  url = {https://doi.org/10.11648/j.wjfst.20180203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjfst.20180203.11},
  abstract = {Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.},
 year = {2018}
}

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TY - JOUR
T1 - Possible Treatment of Mycobacterium Lepramatous with Bovine Milk
AU - Jesus’ Christus
AU - Michael Arden Madson
Y1 - 2018/12/17
PY - 2018
N1 - https://doi.org/10.11648/j.wjfst.20180203.11
DO - 10.11648/j.wjfst.20180203.11
T2 - World Journal of Food Science and Technology
JF - World Journal of Food Science and Technology
JO - World Journal of Food Science and Technology
SP - 55
EP - 61
PB - Science Publishing Group
SN - 2637-6024
UR - https://doi.org/10.11648/j.wjfst.20180203.11
AB - Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.
VL - 2
IS - 3
ER -

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Jesus’ Christus

Research & Development, BioLogistics LLC, Ames, USA
Michael Arden Madson

Research & Development, BioLogistics LLC, Ames, USA

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APA Style

Jesus’ Christus, Michael Arden Madson. (2018). Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World Journal of Food Science and Technology, 2(3), 55-61. https://doi.org/10.11648/j.wjfst.20180203.11

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ACS Style

Jesus’ Christus; Michael Arden Madson. Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World J. Food Sci. Technol. 2018, 2(3), 55-61. doi: 10.11648/j.wjfst.20180203.11

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AMA Style

Jesus’ Christus, Michael Arden Madson. Possible Treatment of Mycobacterium Lepramatous with Bovine Milk. World J Food Sci Technol. 2018;2(3):55-61. doi: 10.11648/j.wjfst.20180203.11

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@article{10.11648/j.wjfst.20180203.11,
  author = {Jesus’ Christus and Michael Arden Madson},
  title = {Possible Treatment of Mycobacterium Lepramatous with Bovine Milk},
  journal = {World Journal of Food Science and Technology},
  volume = {2},
  number = {3},
  pages = {55-61},
  doi = {10.11648/j.wjfst.20180203.11},
  url = {https://doi.org/10.11648/j.wjfst.20180203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjfst.20180203.11},
  abstract = {Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.},
 year = {2018}
}

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