C-Reactive Protein and Aggression in Patients with Schizophrenia
International Journal of Psychological and Brain Sciences
Volume 4, Issue 2, April 2019, Pages: 7-12
Received: Apr. 24, 2019; Accepted: May 24, 2019; Published: Jun. 10, 2019
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Kachouchi Aymen, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Zemrani Yassin, Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Ahroui Yassine, Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Salim Said, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Berghalout Mohammed, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Adali Imane, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Manoudi Fatiha, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
Chabaa Laila, Biochemestry, Laboratory Arrazi, CHU Marrakech, Morocco
Asri Fatima, Research Team for Mental Health, Department of Psychiatry Marrakech, CHU Marrakech, Morocco
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Recent studies reported firstly an association between aggression and inflammation and secondly an association between inflammation and schizophrenia. In this study, we aim to explore the association between the clinical signs of schizophrenia, aggressive behavior in patients with relapsing schizophrenia and inflammatory marker: CRP (C-reactive protein). Adult schizophrenia inpatients without affective symptoms (n = 154) were prospectively identified and categorized according to their C-reactive protein measurement at admission as either elevated (CRP > 5 mg/L; n = 52) or normal (CRP < 5 mg/L; n = 102). The following indicators of aggression were compared: PANSS excitement component (PANSS-EC), restraints, injectable treatment and suicidal behavior during hospitalization. Univariate comparisons between elevated and normal CRP levels were performed and multivariate analysis was conducted to control for relevant covariates. Inpatients with elevated C-reactive protein displayed increased aggressive behavior compared to patients with normal CRP levels (<5 mg/L). This was manifested by increased PANSS-EC score (p=0,0001), higher rates of restraint during hospitalization (p=0,0001), higher use of injectable treatment (0,0001) and existence of suicidal behavior (p=0,001). Multivariate analysis revealed that Lymphocyte count, total PANSS score, PANSS excitement score were independently associated with a CRP> 5 mg/L. These results confirm the role played by inflammation and immunity in the appearance of aggressive behavior in schizophrenic patients and highlight the interest of the CRP assay at the admission of patients as an indicator of aggression in hospitalized schizophrenic patients.
Schizophrenia, Inflammation, Aggression, CRP
To cite this article
Kachouchi Aymen, Zemrani Yassin, Ahroui Yassine, Salim Said, Berghalout Mohammed, Adali Imane, Manoudi Fatiha, Chabaa Laila, Asri Fatima, C-Reactive Protein and Aggression in Patients with Schizophrenia, International Journal of Psychological and Brain Sciences. Vol. 4, No. 2, 2019, pp. 7-12. doi: 10.11648/j.ijpbs.20190402.11
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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