The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis

Arturo Solano-Urrusquieta; Nelson Eduardo Alvarez-Licona; Jose Antonio Morales-Gonzalez; Raul Fierros-Oceguera; Javier Bastida-Alquicira; Alicia Sarahi Ojeda-Yuren; Eira Cerda-Reyes

doi:doi:10.11648/j.ajim.20210903.16

The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis

Arturo Solano-Urrusquieta, Nelson Eduardo Alvarez-Licona, Jose Antonio Morales-Gonzalez, Raul Fierros-Oceguera, Javier Bastida-Alquicira, Alicia Sarahi Ojeda-Yuren, Eira Cerda-Reyes

Published in American Journal of Internal Medicine (Volume 9, Issue 3)

Received: 24 March 2021 Accepted: 21 April 2021 Published: 4 June 2021

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Abstract

Lysosomal acid lipase is an enzyme that intervenes in the last steps of lipid metabolism to hydrolyze cholesteryl esters. Patients with cryptogenic cirrhosis present a clear deficiency of lysosomal acid lipase with an unknown mechanism. Design: The present study has an analytical and retrospective design, of a sample of 55 patients with cryptogenic cirrhosis. The degree of association of lysosomal acid lipase was determined with the results of the enzymes alanine aminotransferase and alkaline phosphatase, as well as with the clinical manifestations of portal hypertension and splenic volume. The sensitivity and specificity of the test were determined for the diagnosis of the manifestations of portal hypertension. Results: The most frequent complication of portal hypertension was variceal hemorrhage with 40%, followed by ascites with 32.7%, and last, by hepatic encephalopathy, with 18.2%. Association by the x² test was without statistical significance with values of 0.177, 0.299, and 0.184 for encephalopathy, variceal hemorrhage, and ascites, respectively. The association of lysosomal acid lipase and splenic volume utilizing the Student t-test had a low degree of association and p >0.05. Through ROC curves, we obtained AUROC results close to 0.5. Conclusion: It is established that there is no correlation of the levels of activity of lysosomal acid lipase with the values of alanine aminotransferase and alkaline phosphatase, as well as with the presence or absence of clinical manifestations and by ultrasound of portal hypertension. Lysosomal acid lipase is not a good test for the diagnosis of the clinical manifestations of portal hypertension.

Published in	American Journal of Internal Medicine (Volume 9, Issue 3)
DOI	10.11648/j.ajim.20210903.16
Page(s)	142-147
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lysosomal Acid Lipase, Cryptogenic Cirrhosis, Portal Hypertension, Liver Cirrhosis, Liver Cirrhosis

References

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APA Style

Arturo Solano-Urrusquieta, Nelson Eduardo Alvarez-Licona, Jose Antonio Morales-Gonzalez, Raul Fierros-Oceguera, Javier Bastida-Alquicira, et al. (2021). The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. American Journal of Internal Medicine, 9(3), 142-147. https://doi.org/10.11648/j.ajim.20210903.16

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ACS Style

Arturo Solano-Urrusquieta; Nelson Eduardo Alvarez-Licona; Jose Antonio Morales-Gonzalez; Raul Fierros-Oceguera; Javier Bastida-Alquicira, et al. The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. Am. J. Intern. Med. 2021, 9(3), 142-147. doi: 10.11648/j.ajim.20210903.16

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AMA Style

Arturo Solano-Urrusquieta, Nelson Eduardo Alvarez-Licona, Jose Antonio Morales-Gonzalez, Raul Fierros-Oceguera, Javier Bastida-Alquicira, et al. The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. Am J Intern Med. 2021;9(3):142-147. doi: 10.11648/j.ajim.20210903.16

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@article{10.11648/j.ajim.20210903.16,
  author = {Arturo Solano-Urrusquieta and Nelson Eduardo Alvarez-Licona and Jose Antonio Morales-Gonzalez and Raul Fierros-Oceguera and Javier Bastida-Alquicira and Alicia Sarahi Ojeda-Yuren and Eira Cerda-Reyes},
  title = {The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {3},
  pages = {142-147},
  doi = {10.11648/j.ajim.20210903.16},
  url = {https://doi.org/10.11648/j.ajim.20210903.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.16},
  abstract = {Lysosomal acid lipase is an enzyme that intervenes in the last steps of lipid metabolism to hydrolyze cholesteryl esters. Patients with cryptogenic cirrhosis present a clear deficiency of lysosomal acid lipase with an unknown mechanism. Design: The present study has an analytical and retrospective design, of a sample of 55 patients with cryptogenic cirrhosis. The degree of association of lysosomal acid lipase was determined with the results of the enzymes alanine aminotransferase and alkaline phosphatase, as well as with the clinical manifestations of portal hypertension and splenic volume. The sensitivity and specificity of the test were determined for the diagnosis of the manifestations of portal hypertension. Results: The most frequent complication of portal hypertension was variceal hemorrhage with 40%, followed by ascites with 32.7%, and last, by hepatic encephalopathy, with 18.2%. Association by the x² test was without statistical significance with values of 0.177, 0.299, and 0.184 for encephalopathy, variceal hemorrhage, and ascites, respectively. The association of lysosomal acid lipase and splenic volume utilizing the Student t-test had a low degree of association and p >0.05. Through ROC curves, we obtained AUROC results close to 0.5. Conclusion: It is established that there is no correlation of the levels of activity of lysosomal acid lipase with the values of alanine aminotransferase and alkaline phosphatase, as well as with the presence or absence of clinical manifestations and by ultrasound of portal hypertension. Lysosomal acid lipase is not a good test for the diagnosis of the clinical manifestations of portal hypertension.},
 year = {2021}
}

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TY  - JOUR
T1  - The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis
AU  - Arturo Solano-Urrusquieta
AU  - Nelson Eduardo Alvarez-Licona
AU  - Jose Antonio Morales-Gonzalez
AU  - Raul Fierros-Oceguera
AU  - Javier Bastida-Alquicira
AU  - Alicia Sarahi Ojeda-Yuren
AU  - Eira Cerda-Reyes
Y1  - 2021/06/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210903.16
DO  - 10.11648/j.ajim.20210903.16
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 142
EP  - 147
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210903.16
AB  - Lysosomal acid lipase is an enzyme that intervenes in the last steps of lipid metabolism to hydrolyze cholesteryl esters. Patients with cryptogenic cirrhosis present a clear deficiency of lysosomal acid lipase with an unknown mechanism. Design: The present study has an analytical and retrospective design, of a sample of 55 patients with cryptogenic cirrhosis. The degree of association of lysosomal acid lipase was determined with the results of the enzymes alanine aminotransferase and alkaline phosphatase, as well as with the clinical manifestations of portal hypertension and splenic volume. The sensitivity and specificity of the test were determined for the diagnosis of the manifestations of portal hypertension. Results: The most frequent complication of portal hypertension was variceal hemorrhage with 40%, followed by ascites with 32.7%, and last, by hepatic encephalopathy, with 18.2%. Association by the x² test was without statistical significance with values of 0.177, 0.299, and 0.184 for encephalopathy, variceal hemorrhage, and ascites, respectively. The association of lysosomal acid lipase and splenic volume utilizing the Student t-test had a low degree of association and p >0.05. Through ROC curves, we obtained AUROC results close to 0.5. Conclusion: It is established that there is no correlation of the levels of activity of lysosomal acid lipase with the values of alanine aminotransferase and alkaline phosphatase, as well as with the presence or absence of clinical manifestations and by ultrasound of portal hypertension. Lysosomal acid lipase is not a good test for the diagnosis of the clinical manifestations of portal hypertension.
VL  - 9
IS  - 3
ER  -

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Author Information

Arturo Solano-Urrusquieta

Internal Assistance Department, Secretary of National Defense, Mexico City, Mexico
Nelson Eduardo Alvarez-Licona

Post-graduate Department, Higher School of Medicine, National Polytechnic Institute, Mexico City, Mexico
Jose Antonio Morales-Gonzalez

Laboratory of Conservation Medicine, Higher School of Medicine National Polytechnic Institute, México City, Mexico
Raul Fierros-Oceguera

Department of Palliative Care, “El Buen Samaritano” Hospital, Mexico City, Mexico
Javier Bastida-Alquicira

Radiology Department, Ultrasonography and non-Invasive Images Section, Central Military Hospital, City of Mexico, Mexico
Alicia Sarahi Ojeda-Yuren

Faculty of Bioethics, Anahuac University Mexico, Mexico City, Mexico
Eira Cerda-Reyes

Gastroenterology Section, Central Military Hospital, Mexico City, Mexico

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Arturo Solano-Urrusquieta, Nelson Eduardo Alvarez-Licona, Jose Antonio Morales-Gonzalez, Raul Fierros-Oceguera, Javier Bastida-Alquicira, et al. (2021). The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. American Journal of Internal Medicine, 9(3), 142-147. https://doi.org/10.11648/j.ajim.20210903.16

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ACS Style

Arturo Solano-Urrusquieta; Nelson Eduardo Alvarez-Licona; Jose Antonio Morales-Gonzalez; Raul Fierros-Oceguera; Javier Bastida-Alquicira, et al. The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. Am. J. Intern. Med. 2021, 9(3), 142-147. doi: 10.11648/j.ajim.20210903.16

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AMA Style

Arturo Solano-Urrusquieta, Nelson Eduardo Alvarez-Licona, Jose Antonio Morales-Gonzalez, Raul Fierros-Oceguera, Javier Bastida-Alquicira, et al. The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis. Am J Intern Med. 2021;9(3):142-147. doi: 10.11648/j.ajim.20210903.16

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@article{10.11648/j.ajim.20210903.16,
  author = {Arturo Solano-Urrusquieta and Nelson Eduardo Alvarez-Licona and Jose Antonio Morales-Gonzalez and Raul Fierros-Oceguera and Javier Bastida-Alquicira and Alicia Sarahi Ojeda-Yuren and Eira Cerda-Reyes},
  title = {The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {3},
  pages = {142-147},
  doi = {10.11648/j.ajim.20210903.16},
  url = {https://doi.org/10.11648/j.ajim.20210903.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.16},
  abstract = {Lysosomal acid lipase is an enzyme that intervenes in the last steps of lipid metabolism to hydrolyze cholesteryl esters. Patients with cryptogenic cirrhosis present a clear deficiency of lysosomal acid lipase with an unknown mechanism. Design: The present study has an analytical and retrospective design, of a sample of 55 patients with cryptogenic cirrhosis. The degree of association of lysosomal acid lipase was determined with the results of the enzymes alanine aminotransferase and alkaline phosphatase, as well as with the clinical manifestations of portal hypertension and splenic volume. The sensitivity and specificity of the test were determined for the diagnosis of the manifestations of portal hypertension. Results: The most frequent complication of portal hypertension was variceal hemorrhage with 40%, followed by ascites with 32.7%, and last, by hepatic encephalopathy, with 18.2%. Association by the x² test was without statistical significance with values of 0.177, 0.299, and 0.184 for encephalopathy, variceal hemorrhage, and ascites, respectively. The association of lysosomal acid lipase and splenic volume utilizing the Student t-test had a low degree of association and p >0.05. Through ROC curves, we obtained AUROC results close to 0.5. Conclusion: It is established that there is no correlation of the levels of activity of lysosomal acid lipase with the values of alanine aminotransferase and alkaline phosphatase, as well as with the presence or absence of clinical manifestations and by ultrasound of portal hypertension. Lysosomal acid lipase is not a good test for the diagnosis of the clinical manifestations of portal hypertension.},
 year = {2021}
}

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TY  - JOUR
T1  - The Severity of the Clinical Expression of Lysosomal Acid Lipase in Patients with Cryptogenic Cirrhosis
AU  - Arturo Solano-Urrusquieta
AU  - Nelson Eduardo Alvarez-Licona
AU  - Jose Antonio Morales-Gonzalez
AU  - Raul Fierros-Oceguera
AU  - Javier Bastida-Alquicira
AU  - Alicia Sarahi Ojeda-Yuren
AU  - Eira Cerda-Reyes
Y1  - 2021/06/04
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210903.16
DO  - 10.11648/j.ajim.20210903.16
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 142
EP  - 147
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210903.16
AB  - Lysosomal acid lipase is an enzyme that intervenes in the last steps of lipid metabolism to hydrolyze cholesteryl esters. Patients with cryptogenic cirrhosis present a clear deficiency of lysosomal acid lipase with an unknown mechanism. Design: The present study has an analytical and retrospective design, of a sample of 55 patients with cryptogenic cirrhosis. The degree of association of lysosomal acid lipase was determined with the results of the enzymes alanine aminotransferase and alkaline phosphatase, as well as with the clinical manifestations of portal hypertension and splenic volume. The sensitivity and specificity of the test were determined for the diagnosis of the manifestations of portal hypertension. Results: The most frequent complication of portal hypertension was variceal hemorrhage with 40%, followed by ascites with 32.7%, and last, by hepatic encephalopathy, with 18.2%. Association by the x² test was without statistical significance with values of 0.177, 0.299, and 0.184 for encephalopathy, variceal hemorrhage, and ascites, respectively. The association of lysosomal acid lipase and splenic volume utilizing the Student t-test had a low degree of association and p >0.05. Through ROC curves, we obtained AUROC results close to 0.5. Conclusion: It is established that there is no correlation of the levels of activity of lysosomal acid lipase with the values of alanine aminotransferase and alkaline phosphatase, as well as with the presence or absence of clinical manifestations and by ultrasound of portal hypertension. Lysosomal acid lipase is not a good test for the diagnosis of the clinical manifestations of portal hypertension.
VL  - 9
IS  - 3
ER  -

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