Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Natalya Avtandilovna Raspopina; Shuganov Evgeny Grigoryevich; Salmasi Jean Mustafaevich; Shuganov Altxander Evgenyevich; Popova Elena Nikolaevna; Subbotina Tatyana Igorevna; Filippova Tamara Vladimirovna

doi:doi:10.11648/j.ajim.20210903.17

Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, Subbotina Tatyana Igorevna, Filippova Tamara Vladimirovna

Published in American Journal of Internal Medicine (Volume 9, Issue 3)

Received: 25 April 2021 Accepted: 18 May 2021 Published: 7 June 2021

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Abstract

Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.

Published in	American Journal of Internal Medicine (Volume 9, Issue 3)
DOI	10.11648/j.ajim.20210903.17
Page(s)	148-152
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Asthma, Chronic Obstructive Pulmonary Disease, Differential Diagnosis, Immune Inflammation, Cytotoxic Lymphocytes, CD Antibodies

References

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Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. (2021). Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. American Journal of Internal Medicine, 9(3), 148-152. https://doi.org/10.11648/j.ajim.20210903.17

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ACS Style

Natalya Avtandilovna Raspopina; Shuganov Evgeny Grigoryevich; Salmasi Jean Mustafaevich; Shuganov Altxander Evgenyevich; Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am. J. Intern. Med. 2021, 9(3), 148-152. doi: 10.11648/j.ajim.20210903.17

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AMA Style

Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am J Intern Med. 2021;9(3):148-152. doi: 10.11648/j.ajim.20210903.17

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@article{10.11648/j.ajim.20210903.17,
  author = {Natalya Avtandilovna Raspopina and Shuganov Evgeny Grigoryevich and Salmasi Jean Mustafaevich and Shuganov Altxander Evgenyevich and Popova Elena Nikolaevna and Subbotina Tatyana Igorevna and Filippova Tamara Vladimirovna},
  title = {Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {3},
  pages = {148-152},
  doi = {10.11648/j.ajim.20210903.17},
  url = {https://doi.org/10.11648/j.ajim.20210903.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.17},
  abstract = {Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.},
 year = {2021}
}

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TY  - JOUR
T1  - Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features
AU  - Natalya Avtandilovna Raspopina
AU  - Shuganov Evgeny Grigoryevich
AU  - Salmasi Jean Mustafaevich
AU  - Shuganov Altxander Evgenyevich
AU  - Popova Elena Nikolaevna
AU  - Subbotina Tatyana Igorevna
AU  - Filippova Tamara Vladimirovna
Y1  - 2021/06/07
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210903.17
DO  - 10.11648/j.ajim.20210903.17
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 148
EP  - 152
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210903.17
AB  - Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.
VL  - 9
IS  - 3
ER  -

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Author Information

Natalya Avtandilovna Raspopina

Institute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia
Shuganov Evgeny Grigoryevich

Department of Therapy, State Budgetary Institution Moscow Regional Research and Clinical Institute n. a. M. F. Vladimirsky. Moscow, Russia
Salmasi Jean Mustafaevich

Pirogov Russian National Research Medical University (RNRMU) of Ministry of Health of Russia, Moscow, Russia
Shuganov Altxander Evgenyevich

Department of Therapy, State Budgetary Institution Moscow Regional Research and Clinical Institute n. a. M. F. Vladimirsky. Moscow, Russia
Popova Elena Nikolaevna

Institute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia
Subbotina Tatyana Igorevna

nstitute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia
Filippova Tamara Vladimirovna

nstitute of Clinical Sciences, Sechenov First Moscow State Medical University of Ministry of Health of Russia (Sechenov University), Moscow, Russia

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Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. (2021). Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. American Journal of Internal Medicine, 9(3), 148-152. https://doi.org/10.11648/j.ajim.20210903.17

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ACS Style

Natalya Avtandilovna Raspopina; Shuganov Evgeny Grigoryevich; Salmasi Jean Mustafaevich; Shuganov Altxander Evgenyevich; Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am. J. Intern. Med. 2021, 9(3), 148-152. doi: 10.11648/j.ajim.20210903.17

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AMA Style

Natalya Avtandilovna Raspopina, Shuganov Evgeny Grigoryevich, Salmasi Jean Mustafaevich, Shuganov Altxander Evgenyevich, Popova Elena Nikolaevna, et al. Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features. Am J Intern Med. 2021;9(3):148-152. doi: 10.11648/j.ajim.20210903.17

Copy | Download

@article{10.11648/j.ajim.20210903.17,
  author = {Natalya Avtandilovna Raspopina and Shuganov Evgeny Grigoryevich and Salmasi Jean Mustafaevich and Shuganov Altxander Evgenyevich and Popova Elena Nikolaevna and Subbotina Tatyana Igorevna and Filippova Tamara Vladimirovna},
  title = {Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features},
  journal = {American Journal of Internal Medicine},
  volume = {9},
  number = {3},
  pages = {148-152},
  doi = {10.11648/j.ajim.20210903.17},
  url = {https://doi.org/10.11648/j.ajim.20210903.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.17},
  abstract = {Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.},
 year = {2021}
}

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TY  - JOUR
T1  - Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features
AU  - Natalya Avtandilovna Raspopina
AU  - Shuganov Evgeny Grigoryevich
AU  - Salmasi Jean Mustafaevich
AU  - Shuganov Altxander Evgenyevich
AU  - Popova Elena Nikolaevna
AU  - Subbotina Tatyana Igorevna
AU  - Filippova Tamara Vladimirovna
Y1  - 2021/06/07
PY  - 2021
N1  - https://doi.org/10.11648/j.ajim.20210903.17
DO  - 10.11648/j.ajim.20210903.17
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 148
EP  - 152
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20210903.17
AB  - Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.
VL  - 9
IS  - 3
ER  -

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